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| 1 | No apparent lock-in depth of the Laschamp geomagnetic excursion: Evidence from the Malan loess显示文摘The first-order chronological framework of the long-term Chinese loess/paleosol sequences was based mainly on magnetostratigraphy. However, there remain arguments on the lock-in ages of the major geomagnetic reversals. This study systematically compared the stratigraphic locations of the Laschamp excursion and Henrich events (H4 at~39 ka and H5 at~48 ka) recorded by the Luochuan loess profile in the central Chinese Loess Plateau. Results show that the Lascchamp excursion is bracketed well by these two cold events, and the corresponding estimated age is between about 41.7-43.7 ka, which is close to the widely accepted age of ~40-41 ka for the excursion.Therefore, our new results do not suggest apparent lock-in effects in the last glacial Malan loess. | ZHU Rixiang1, LIU Qingsong1,2, PAN Yongxin1, DENG Chenglong1, ZHANG Rui1 & WANG Xianfeng3 1. Paleomagnetism and Geochronology Laboratory (SKL of Lithosphere Evolution), Institute of Geology and Geophysics, Chi- nese Academy of Sciences, Beijing 100029, China 2. Institute of Geophysics and Planetary Geophysics, University of California, Santa Cruz, CA 95064, USA 3. Department of Geology and Geophysics, University of Minnesota, Minneapolis, MN 55455, USA | 2006 | Science China Earth Sciences2006，49，9： | 12 |
| 2 | Discovery and analysis of ultra-micro grinding grain texture in slipping lamellae of ductile-brittle zone显示文摘Based on the observation of the deep bore cores sampled from the State of Cali-fornia, USA, preferred arranged particulate concentration belts were found in the ultra-slipping lamellae. And the same phenomenon was found again later in the bore cores from the petroleum basin in the Northern Shaanxi Province. It may be the product of the dynamic processes involv-ing tumbling, grinding and compresso-shearing functions, so the spherical particulates with ul-tra-size of nm and mm are called grinding grain. The formation of the grinding grains is related with the ductile-brittle deformation, the lateral pressure of the slipping, and the very low grade of dynamic metamorphism of the rocks. Based on the systematic analysis, it is indicated that some elements like Nb and Ta are enriched in the grinding grains in the granitic rocks because of the chemical differentiation, and that the slipping lamellae bearing grinding grains in mudstone with smear efficiency prove a perfect seal for oil and gas reservoirs. Meanwhile, the paper provides bases for the studies on the fast stick-slip movement and shear paradigm. | GE Heping1, SUN Yan1, LU Xiancai1, ZHU Wenbin1, GUO Jichun1, LIU Deliang2 & Chi-yuen Wang3 1. Department of Earth Sciences, Nanjing University, State Key Laboratory of Mineral Deposit, Nanjing 210093, China 2. Department of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, China 3. Department of Geology and Geophysics, University of California, Berkeley, CA 94720, USA | 2004 | Science China Earth Sciences2004，47，3： | 9 |
| 3 | Comparative studies on epithelial lesions at gastric cardia and pyloric antrum in subjects from a high incidence area for esophageal cancer in Henan,China显示文摘ComparativestudiesonepitheliallesionsatgastriccardiaandpyloricantruminsubjectsfromahighincidenceareaforesophagealcancerinHena... | GAO ShanShan1, ZHOU Qi1, LI YongXin1, BAI YongMin1, ZHENG ZuoYu1, ZOU JianXiang1, LIU Gang1, FAN ZongMin1, QI YiJun1, ZHAO Xin1 and WANG LiDong1,2Keywords esophageal neoplasms stomach neoplasms gastric ca | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 4 | Regulatory mechanisms for abnormal expression of the human breast cancer specific gene 1 in breast cancer cells显示文摘Breast cancer-specific gene 1 (BCSG1), also referred as synuclein γ, was originally iso-lated from a human breast cancer cDNA library and the protein is mainly localized to presynaptic terminals in the nervous system. BCSG1 is not expressed in normal or benign breast lesions, but expressed at an extremely high level in the vast majority of the advanced staged breast carcinomas and ovarian carcinomas. Overexpression of BCSG1 in cancer cells led to significant increase in cell proliferation, motility and invasiveness, and metastasis. To elucidate the molecular mechanism and regulation for abnormal transcription of BCSG1, a variety of BCSG1 promoter luciferase reporters were constructed including 3′ end deleted sequences, Sp1 deleted, and activator protein-1 (AP1) domains mutated. Transient transfection assay was used to detect the transcriptional activation of BCSG1 promoters. Results showed that the Sp1 sequence in 5′-flanking region was involved in the basal transcriptional activities of BCSG1 without cell-type specificity. In comparison to pGL3-1249, the reporter activities of pGL3-1553 in BCSG1-negative MCF-7 cells and pGL3-1759 in HepG2 cells were notably decreased. Mutations at AP1 sites in BCSG1 intron 1 significantly reduced the promoter ac-tivity in all cell lines. Transcription factors, c-jun, c-fos and cyclin AMP-responsive element binding (CREB) protein, could markedly enhance the promoter activities. Thus, our results suggest that the abnormal expression of BCSG1 in breast cancer cells is likely regulated by multiple mechanisms. The 5′ flanking region of BCSG1 provides the basal transcriptional activity without cell type specificity. A critical promoter element involved in abnormal expression of BCSG1 presents in the first exon. The cell type specificity of BCSG1 transcription is probably affected through intronic cis-regulatory se-quences. AP1 domains in the first intron play an important role in control of BCSG1 transcription. | LU Aiping1, LI Qing1, LIU Jingwen2 1. Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China 2. VA Palo alto Health Care System, Palo Alto, California, CA 94304, USA | 2006 | Science China(Life Sciences)2006，49，4： | 8 |
| 5 | microRNAs-powerful repression comes from small RNAs显示文摘microRNAs (miRNAs) encode a novel class of small, non-coding RNAs that regulate gene expression post-trancriptionally. miRNAs comprise one of the major non-coding RNA families, whose diverse bio- logical functions and unusual capacity for gene regulation have attracted enormous interests in the RNA world. Over the past 16 years, genetic, biochemical and computational approaches have greatly shaped the growth of the field, leading to the identification of thousands of miRNA genes in nearly all metazoans. The key molecular machinery for miRNA biogenesis and silencing has been identified, yet the precise biochemical and regulatory mechanisms still remain elusive. However, recent findings have shed new light on how miRNAs are generated and how they function to repress gene expression. miRNAs provide a paradigm for endogenous small RNAs that mediate gene silencing at a genome-wide level. The gene silencing mediated by these small RNAs constitutes a major component of gene regu- lation during various developmental and physiological processes. The accumulating knowledge about their biogenesis and gene silencing mechanism will add a new dimension to our understanding about the complex gene regulatory networks. | MA Cong, LIU YuFei & HE Lin 535 LSA, Division of Cell and Developmental Biology, MCB Department, University of California at Berkeley, Berkeley, CA 94720-3200 | 2009 | Science China(Life Sciences)2009，52，4： | 7 |
| 6 | Kinetics of early methane generation from Green River shale显示文摘During oil/gas exploration in an area, there is a question as to whether methane in the strata was generated \%in situ\% mainly by thermal degradation of local organic matter. The key to the question is whether the kerogen could produce methane of more than 80 mL/g TOC, when its \%R\%\-o increased from initial (0.36%) to current value of 0.70% during thermal evolution. The authors have made efforts to answer this question by the kinetics method. First, a series of pyrolysis experiments were carried out to obtain data of methane yield and \%R\%\-o evolution, from which kinetic parameters of methane and \%R\%\-o were derived; then these parameters were extrapolated to the geological condition and finally, a methane yield, 96 mL/g TOC, was predicted. The result suggests that from the view of hydrocarbon generation, methane in the seam should be from thermal degradation of local kerogen. | LIU Jinzhong\+1 and TANG Yongchun 2 1. Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 2. Chevron Petroleum Technology Company, CA 90633, USA | 1998 | Chinese Science Bulletin1998，43，22： | 7 |
| 7 | Posterior gut development in Drosophila:a model system for identifying genes controlling epithelial morphogenesis显示文摘The posterior gut of the Drosophila embryo, consisting of hindgut and Malpighian tubules, provides a simple,well-defined system where it is possible to use a genetic approach to define components essential for epithelial morphogenesis.We review here the advantages of Drosophila as a model genetic organism, the morphogenesis of the epithelial structures of the posterior gut, and what is known about the genetic requirements to form these structures.In overview, primordia are patterned by expression of hierarchies of transcription factors; this leads to localized expression of cell signaling molecules, and finally, to the least understood step: modulation of cell adhesion and cell shape. We describe approaches to identify additional genes that are required for morphogenesis of these simple epithelia, particularly those that might play a structural role by affecting cell adhesion and cell shape. | LENGYEL JUDITH A XUE JUN LIU (Department of Molecular, Cell and Developmental Biology University of California at Los Angeles, Los Angeles, CA USA, 90095-1606 USA) | 1998 | Cell Research1998，8，4： | 5 |
| 8 | Macroscopic relationship for preferential flow in the vadose zone:Theory and validation显示文摘Preferential flow commonly observed in unsaturated soils allows rapid movement of solute from the ground surface or vadose zone to the groundwater, bypassing a significant volume of unsaturated soil and increasing the risk of groundwater contamination. A variety of evidence indicates that complex preferential flow patterns observed from fields are fractals. This paper discusses a macroscopic relationship for modeling preferential flow in the vadose zone. Conceptually, the flow domain can be divided into active and inactive regions. Flow occurs preferentially in the active region (characterized by fractals), and inactive region is simply bypassed. The portion of the active region was found to be a power function of saturation. The validity of this macroscopic relationship is demonstrated by its consistency with field observations and the related numerical experiments. | LIU HuiHai1 & ZHANG RenDuo2 1 Earth Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 947200, USA 2 School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China | 2009 | Science China(Technological Sciences)2009，52，11： | 5 |
| 9 | Time-periodic solutions of the Einstein's field equations Ⅰ:general framework显示文摘In this paper,we develop a new algorithm to find the exact solutions of the Einstein's field equations.Time-periodic solutions are constructed by using the new algorithm.The singularities of the time-periodic solutions are investigated and some new physical phenomena,such as degenerate event horizon and time-periodic event horizon,are found.The applications of these solutions in modern cosmology and general relativity are expected. | KONG DeXing1 & LIU KeFeng2 1Department of Mathematics,Zhejiang University,Hangzhou 310027,China 2Department of Mathematics,University of California at Los Angeles,CA 90095,USA | 2010 | Science China Mathematics2010，53，5： | 5 |
| 10 | Global existence of smooth solutions to two-dimensional compressible isentropic Euler equations for Chaplygin gases显示文摘In this paper we investigate the two-dimensional compressible isentropic Euler equations for Chaplygin gases. Under the assumption that the initial data is close to a constant state and the vorticity of the initial velocity vanishes, we prove the global existence of the smooth solution to the Cauchy problem for twodimensional flow of Chaplygin gases. | KONG DeXing 1 , LIU KeFeng 2 & WANG YuZhu 3, 1 Department of Mathematics, Zhejiang University, Hangzhou 310027, China 2 Department of Mathematics, University of California at Los Angeles, CA 90095, USA 3 Department of Mathematics, Shanghai Jiao Tong University, Shanghai 200248, China | 2010 | Science China Mathematics2010，53，3： | 4 |
| 11 | Characterization of proteolipid protein-peptide-specific CD_4^+ T cell of experimental allergic encephalomyelitis in Biozzi AB/H mice | Yong Peng and Chih pin Liu Department of Neurology, The Third Affiliated Hospital, Hunan Medical University , Changsha 410013, China (Peng Y) Division of Immunology, Beckman Research Institute, City of Hope National M edical Center, Duarte, CA 9 | 2002 | Chinese Medical Journal2002，，4： | 3 |
| 12 | Time-periodic solutions of the Einstein's field equations II:geometric singularities显示文摘In this paper,we construct several kinds of new time-periodic solutions of the vacuum Einstein's field equations whose Riemann curvature tensors vanish,keep finite or take the infinity at some points in these space-times,respectively.The singularities of these new time-periodic solutions are investigated and some new physical phenomena are discovered. | KONG DeXing1,LIU KeFeng2,& SHEN Ming3 1Department of Mathematics,Zhejiang University,Hangzhou 310027,China 2Department of Mathematics,University of California at Los Angeles,CA 90095,USA 3Center of Mathematical Sciences,Zhejiang University,Hangzhou 310027,China | 2010 | Science China Mathematics2010，53，6： | 3 |
| 13 | School examinations enhance airway inflammation to antigenchallenge显示文摘 | Liu LY Coe CL Swenson CA Kelly EA Kita H Busse WW | | 0，，： | 1 |
| 14 | Emergence delirium in adults in the post-anaesthesia care unit显示文摘 | Lepousé C Lautner CA Liu L | 2006 | Br J Anaesth2006，96，6： | 1 |
| 15 | Emergence delirium in adults in the post-anaesthesia care unit显示文摘 | Lepouse C Lautner CA Liu L | | 0，，06： | 1 |
| 16 | Emergence delirium in adults in the post-anaesthesia care unit显示文摘 | Lepousé C Lautner CA Liu L | | 0，，06： | 1 |
| 17 | Demographic differencesand trends of vitamin D insufficiency in the US population,1988-2004显示文摘 | Ginde AA Liu MC Camargo CA Jr | 2009 | Arch Intern Med2009，169，6： | 1 |
| 18 | Inhibition of 8-hydroxyuanosine formation by eurcumin in mouse fibroblast cells显示文摘 | Liu JK | 1993 | Cacinogonesis1993，14，4： | 1 |
| 19 | Expression of CD40 ligand on CD4+T cell and platelets correlated to the coronary artery lesion and disease progress in Kawasaki disease 显示文摘 | Wang CL Wu YT Liu CA | 2003 | Padiatrics2003，111，2： | 1 |
| 20 | Modulation of eIF5 A expression using SNS01 nanoparticles inhibits NF - KB activity and tumor growth in murine models of multiple myeloma 显示文摘 | Taylor CA Liu Z Tang TC | 2012 | Mol Ther2012，20，7： | 1 |
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