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| 1 | Finite difference numerical simulation of guided wave propagation in the full grouted rock bolt显示文摘Based on guided wave theory and considering the grouted rock bolt as waveguide medium, we have constructed a three dimensional model of grouted rock bolt with the dynamics of finite difference numerical simulation software FLAC3D4.0, and simulated the propagation behavior of the guided wave in the full grouted rock bolt. The simulated waveform and wave velocity matched well with the experimental results. We have made a more in-depth and comprehensive study of the wave velocity, wave component and attenuation characteristics of the guided wave propagating in rock bolt, and found some new characteristics and phenomena. In addition, some phenomena that haven’t been explained in the previous researches have also been discussed in this paper. The result showed that when guided wave propagates in grouted rock bolt, after the body wave decays, there is still the interface wave-Stoneley wave that does not decay in the axial direction of the bolt. The findings can provide some reference for rock bolt testing and the selection of the optimal excitation wave of testing. | YAN ZhiXin CAI HanCheng WANG QunMin CAO XiaoHong ZHANG LiuPing | 2011 | Science China(Technological Sciences)2011，54，5： | 10 |
| 2 | Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats显示文摘Background: Dexamethasone(Dex), a synthetic glucocorticoid, is among the most commonly used drugs worldwide in animals and humans as an anti-inflammatory and immunosuppressive agent. GC has profound effects on plasma glucose level and other metabolic conditions. However, the effect of prolonged use of Dex on glucose metabolism in ruminants is still unclear.Results: Ten goats were randomly assigned to two groups: the control goats were injected with saline, and the Dex-treated goats were intramuscularly injected daily for 21 d with 0.2 mg/kg Dex. The results showed that plasma glucose and insulin concentrations were significantly increased after Dex administration(P < 0.05). Additionally, the content of hepatic glycogen was also markedly increased in Dex-treated goats(P < 0.01), while the content of glycogen in dorsal longissimus was unchanged by Dex(P > 0.05). The expression of several key genes, involved in blood glucose regulation, was detected by real-time PCR in the small intestine, skeletal muscle and liver. The expression of glucose transporter type 2(GLUT2), sodium-glucose transporter 1(SGLT1) and sodium-potassium ATPase(Na-K/ATPase) in the small intestine were generally increased by Dex, and GLUT2 m RNA expression was significantly up-regulated(P < 0.05). In liver, the expression of genes involved in gluconeogenesis including glucose-6-phosphatase catalytic subunit(G6 PC), cytosolic form of phosphoenolpyruvate carboxykinase(PCK1) and pyruvate carboxylase(PC), were significantly down-regulated by Dex. However, the protein expression levels of PCK1 & PCK2 were significantly increased by Dex, suggesting a post-transcriptional regulation. In dorsal longissimus, the m RNA expression of genes associated with gluconeogenesis and the insulin signaling pathway were generally upregulated by Dex, but the m RNA expression of two markers of muscle atrophy, namely F-box protein 32(FBXO32/Atrogin1) and muscle RING-finger protein 1(Mu RF1), was not altered by Dex.Conclusions: Taken together, these results indicate that chronic administration of a low dosage of Dex induces hyperglycemia mainly through gluconeogenesis activation in the goat liver. | Liqiong Niu Qu Chen Canfeng Hua Yali Geng Liuping Cai Shiyu Tao Yingdong Ni Ruqian Zhao | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 1 |
| 3 | 1, 3-Bis-dibutyl- aminopropan-2-olas inhibitor for reinfor cerement steel in chloride-contaminated simulated concrete pore solu- tion 显示文摘 | Liu Chen C C Cai | 2013 | Mater Corros2013，64，12： | 1 |
| 4 | Whole transcriptome analysis of RNA expression profiles reveals the potential regulating action of long noncoding RNA in lactating cows fed a high concentrate diet显示文摘Subacute ruminal acidosis(SARA)is a common metabolic disease in the dairy farming industry which is usually caused by an excessive amount of high concentrate diet.SARA not only threatens animal welfare but also leads to economic losses in the farming industry.The liver plays an important role in the distribution of nutritional substances and metabolism;however,a high concentrate diet can cause hepatic metabolic disorders and liver injury.Recently,noncoding RNA has been considered as a critical regulator of hepatic disease,however,its role in the bovine liver is limited.In this study,12 mid-lactating dairy cows were randomly assigned to a control(CON)group(40% concentrate of dry matter,n=6)and a SARA group(60% concentrate of dry matter,n=6).After 21 d of treatment,all cows were sacrificed,and liver tissue samples were collected.Three dairy cows were randomly selected from the CON and SARA groups respectively to perform whole transcriptome analysis.More than 20,000 messenger RNA(mRNA),10,000 long noncoding RNA(lncRNA),3,500 circular RNA(circRNA)and 1,000 micro RNA(miRNA)were identified.Furthermore,43 mRNA,121 lncRNA and 3 miRNA were differentially expressed,whereas no obvious differentially expressed circRNA were detected between the 2 groups.Gene Ontology(GO)annotation revealed that the differentially expressed genes were mainly enriched in oxidoreductase activity,stress,metabolism,the immune response,cell apoptosis,and cell proliferation.Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis showed that the deferentially expressed genes were highly enriched in the phosphatidylinositol 3 kinase(PI3) K-serine/threonine kinase(AKT)signaling pathway(P<0.05).According to KEGG pathway analysis,the differentially expressed lncRNA(DElncRNA)target genes were mainly related to proteasomes,peroxisomes,and the hypoxia-inducible factor-1 signaling pathway(P<0.005).Further bioinformatics and integrative analyses revealed that the lncRNA were strongly correlated with mRNA;therefore,it is reasonable to speculate that lncRNA potentially play important roles in the liver dysfunction induced by SARA.Our study provides a valuable resource for future investigations on the mechanisms of SARA to facilitate an understanding of the importance of lncRNA,and offer functional RNA information. | Qu Chen Chen Wu Zhihao Yao Liuping Cai Yingdong Ni Shengyong Mao Ruqian Zhao | 2021 | Animal Nutrition2021，，4： | 0 |
| 5 | Sodium butyrate alleviates fructose-induced non-alcoholic fatty liver disease by remodeling gut microbiota to promoteγ-amino butyric acid production显示文摘Sodium butyrate(NaB)can regulate lipid metabolism and inhibit hepatic steatosis.This study aimed to investigate whether NaB can alleviate fructose-induced hepat ic steatosis via remodeling the gut microbiota and evaluate the anti-fatty liver mechanisms.The results showed that NaB and NaB-remodeled gut microbiota significantly alleviated fructose-induced hepatic steatosis and increased plasma uric acid and fructose levels.Furthermore,both NaB and NaB-remodeled gut microbiota increased the abundance of Lactobacillus and altered the levels of plasma amino acids(upregulating gamma-amino butyric acid(GABA)and downregulating L-glutamic acid and L-arginine)in fructose-exposed mice.The correlation analysis showed that GABA levels positively correlated with Lactobacillus abundance,and increased GABA levels might promote the reduction of the hepatic triglyceride content.Further studies confirmed that GABA significantly reduced lipid deposition in mouse hepatocytes induced via fructose pretreatment in vitro.These findings suggested that NaB could ameliorate fructose-induced hepatic steatosis by regulating gut microbiota. | Qu Chen Lei Wu Aijia Zhang Chen Wu Liuping Cai Yingping Xiao Yingdong Ni | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
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