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| 1 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 2 | PICU内胃残余容积测量:英国的一项临床调查显示文摘目的 尽管证据较少,全球PICU仍广泛采用常规测量胃残余容积来指导肠内喂养起始及给予.鉴于该项措施支持证据的审查增加,且作为试验可行性研究的一部分,本文旨在确定肠内喂养和胃残余容积( gastric residual volume, GRV)测量在英国PICUs的实行情况. 设计 线上调查27家英国PICUs. 场所 英国PICUs. 对象 每家PICU均由临床护士,高年医生及营养师各一名协作完成一份调查问卷,并发回一份他们正实行的肠内喂养及GRV指南附件. 干预 无. 主要结果 89%(24/27) PICUs完成问卷,95. 8%(23/24) PICUs有纸质喂养指南,83%(19/23) PICUs发送了指南用于评议.多数 PICUs 主要采用经胃管持续喂养( 15/24, 62%)而不是间歇喂养(9/24,37%).除1家PICU外其他均常规测量GRV,无论采用何种喂养方式. 18家PICUs定义了喂养耐受指标,均包括GRV.喂养耐受的GRV阈值根据容积( ml/kg, 11/21, 52%)或容积/喂养量百分比(6/21,29%)确定.仅 1/3PICUs 提供了 GRV 测量技术指南. 结论 常规GRV测量为英国PICUs内标准临床治疗的一部分,但指南很少对影响测量GRV精度的技术做出指导.所有定义喂养耐受的PICUs均将GRV纳入指标.将来若提出对重症患儿不做常规GRV测量的临床研究时,需要充分认识到这一现状. | Tume LN Arch B Woolfall K 方伯梁(译) 钱素云(校) | 2019 | 中国小儿急救医学2019，26，10： | 2 |
| 3 | Survival data from a phase II, open- label study of pazopanib or lapatinib monotherapy in patients with advanced and recurrent cervical cancer 显示文摘 | Monk B J Pandite LN | 2011 | J Clin Oncol2011，29，36： | 1 |
| 4 | Auditory hair cell explant co-cultures promote the differentiation of stem ceils into bipolar neurons显示文摘 | Coleman B Fallon JB Gillespie LN | 2007 | Exp Cell Res2007，313，： | 1 |
| 5 | Identification of nine novel arylsulfatase A (ARSA) gene mutations in patients with metaehromatic leukodystruphy (MLD)显示文摘 | Eng B Nakamura LN O' Reilly N | 2003 | Hum Murat2003，22，： | 1 |
| 6 | Proliferative andmorphological effects of endothelins in schwann cells:Roles ofp38mitogen-activated protein kinase and Ca2+-independent phos-pholipase A2显示文摘 | Berti-Mattera LN Harwalkar S Hughes B | 2001 | J Neurochem2001，79，6： | 1 |
| 7 | Terminology of cell-water relations显示文摘 | Kramer PJ Edward B Knipling EB Miller LN | | 0，，： | 1 |
| 8 | What drives faculty ratings of residents' clinical skills The impact of faculty's own clinical skills 显示文摘 | Kogan JR Hess B J Conforti LN | 2010 | Acad Med2010，85，10： | 1 |
| 9 | Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis 显示文摘 | Gerald LN Nancy B James JLC | 2011 | Bioorg Med Chem2011，19，13： | 1 |
| 10 | Outcomes of ruptured intracranial aneurysms treated by microsurgical clipping and endovascular coiling in a high-volume center显示文摘 | Natarajan SK Sekhar LN Ghodke B | 2008 | AJNR Am J Neuroradiol2008，29，4： | 1 |
| 11 | Carbon- fluorine bond activation coupled with carbon-carbon bond formation at iridium confirmation of complete kinetic diastereoselectivity at the new carbon stereocenter by intramoleeular trapping using vinyl as the migrating group 显示文摘 | Hughes R P Laritchev R B Zakharov LN | 2005 | J Am Chem Soc2005，127，： | 1 |
| 12 | Quetiapine versus placebo in combination with lithium or divalproex for the treatment of bipolar mania显示文摘 | Yatham LN Paulsson B Muleen J | 2004 | J Clin Psychopharmacol2004，24，6： | 1 |
| 13 | Liver transplantation for patients with hepatic alveolar echinoeoccosis in late stage显示文摘 | Pan GD Yan LN Li B | 2004 | Hepatobiliary Pancreat Dis Int2004，3，4： | 1 |
| 14 | Defining the normal bacte- rial flora of the oral cavity显示文摘 | Aas JA Paster B J Stokes LN | 2005 | Clin Microbiol2005，43，11： | 1 |
| 15 | The effectiveness of problem-based learning on development of nursing students' critical thinking: A systematic review and meta-analysis 显示文摘 | Kong LN Qin B Zhou YQ | 2014 | Int J Nuts Stud2014，，3： | 1 |
| 16 | Delta 10ppm versus delta 20ppm:a reappraisal of diagnostic criteria for breath hydrogen testing in children显示文摘 | Veligati LN Treem WR Sullivan B | 1994 | Am J Gastroenterol1994，89，5： | 1 |
| 17 | Primary Ki-1 anaplastic large cell lymphoma in adults: clinical characteristics and therapeutic outcome显示文摘 | Shulman LN Fresard B Antin JH etal | 1993 | J Clin Oncol1993，11，： | 1 |
| 18 | Typing chlamy- dia traehomatis: from egg yolk to nanotechnology 显示文摘 | Pedersen LN Herrmann B Moller JK | 2009 | FEMS lmmunol Med Microbiol2009，55，2： | 1 |
| 19 | A 3D model of wing crack growth and interaction显示文摘 | DYSKIN AV GERMANOVICH LN USTINNOV K B | 1999 | Engineering Fracture Mechanics1999，63，1： | 1 |
| 20 | Speckle tracking for multi -dimensional flow estimation 显示文摘 | Bohs LN Geiman B J Anderson ME | 2000 | Ultrasonics2000，38，18： | 1 |
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