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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | Laser transformation hardening of AISI440C martensitic stainless steel for higher cavitation erosion resistance显示文摘 | Lo K H Cheng F T Man H C | 2003 | Surface and Coating Technology2003，173，： | 2 |
| 3 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 4 | Composting salmon farm mortalities with passive areration显示文摘 | Liao P H Vizcarra A T Chen A Lo K V | 1996 | Compost Science and Utilization1996，2，4： | 2 |
| 5 | Time domain buffeting analysis of suspension bridge subjected to turbulent wind with effective action angle显示文摘 | Ding Q Lee P K K Lo S H | 2000 | Journal of Sound and Vibration2000，233，2： | 1 |
| 6 | Transportation network improvement and tolling strategies: the issue of intergeneration equity 显示文摘 | Szeto W Y Lo H K | 2006 | Transportation Research Part A2006，40，3： | 1 |
| 7 | Simultaneous determination of losartan and EXP3174 in human plasma and urine utilizing liquid chromatography/tandem mass spectrometry显示文摘 | Polinko M Riffel K Song H Lo M W | 2003 | J Pharm Biomed Anal2003，33，： | 1 |
| 8 | Degradable transport network: travel time budget of travelers with heterogeneous risk aversion 显示文摘 | Lo H K Luo X W Siu B W Y | 2006 | Transportation Research Part B2006，40，9： | 1 |
| 9 | A capacity related reliability for transportation networks 显示文摘 | CHEN A YANG H LO H K | 1999 | Journal of Advanced Transportation1999，33，2： | 1 |
| 10 | Two new self-adaptive projection methods for variational inequality problems显示文摘 | Han D Lo H K | 2002 | Computer and Mathematics with Applications2002，43，： | 1 |
| 11 | Reduced expression of APC and DCC gene protein in breast cancer显示文摘 | Ho K Y Kalle W H Lo T H | 1999 | Histopathology1999，35，3： | 1 |
| 12 | Network with degradable links: capacity analysis and design显示文摘 | LO H K TUNG Y K | 2003 | Transportation Research Part B2003，37，4： | 1 |
| 13 | A high- efficiency dimmable LED driver for low-power lighting applications 显示文摘 | CHIU H J LO Y K CHEN J T | 2010 | IEEE Trans Indus Elec2010，57，2： | 1 |
| 14 | Power systems fault diagnosis us- ing Petri nets显示文摘 | Lo K L Ng H S Trecat J | 1997 | IEE Proceddings-Generation Transmis- sion and Distribution1997，144，3： | 1 |
| 15 | Kinematics of upper limb and trunk tennis play- ers using single handed backhand stroke 显示文摘 | Wang 1 Su H lo K | 1998 | International Sypos- ium on Biomehanics in sport1998，，8： | 1 |
| 16 | Building response due to subway train traffic 显示文摘 | Chua K H Lo K W Balendra T | 1995 | Journal of Geotechnical Engineering1995，121，11： | 1 |
| 17 | A Self-adaptive Pro- jection and Contraction Algorithm for the Traffic As- signment Problem with Path-specific Costs显示文摘 | CHEN A LO H K YANG H | 2001 | Euro- pean Journal of Operational Research2001，135，1： | 1 |
| 18 | Cloning and characterizationof Arabidopsis thaliana pyridoxal kinase 显示文摘 | Lum H K Kwok F Lo S C | 2002 | Planta2002，215，： | 1 |
| 19 | Capacity reliability of a road network: an assessment methodology and numerical results 显示文摘 | CHEN A YANG H LO H K | 2002 | Transportation Research2002，36，： | 1 |
| 20 | Computational analysis and experimental validation of tumor- associated alternative splicing in human cancer显示文摘 | Wang Z Lo H S Yang H Gere S Hu Y Buetow K H | 2003 | Cancer Res2003，63，： | 1 |
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