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| 1 | New prospects in the diagnosis and treatment of immune-mediated inner ear disease显示文摘Autoimmune inner ear disease(AIED) represents a very fertile research field and the advancements in the understanding of this disease have a direct application not only in patients affected with this condition but also in other inner ear disorders that share the same injury mechanism, damage to the inner ear hair cells. AIED also presents many challenges that have still to be overcome. Firstly, access to the inner ear is limited, as many interventions such as biopsies can result in great irreversible damage. Secondly, there are no completely specific markers for AIED. Lack of a definitive diagnosis can result in the treatment of patients not affected with the disease and, therefore, no response. Finally, some patients become refractory to glucocorticoids and new therapies are needed. This review offers an overview of the animal models that have contributed to the understanding of AIED pathophysiology, the value of currently available diagnostic tests, and therapeutic options, with a special focus on new therapies for non responders or patients refractory to glucocorticoids. Among these new options for therapy, biological agents have been tested recently, whereas gene and stem celltherapy may have a role in the future. The intratympanic route of administration avoids the systemic side effects associated with currently used drugs, and may become a more frequent approach in the future. | David R Lobo Jose Ramon García-Berrocal Rafael Ramírez-Camacho | 2014 | World Journal of Methodology2014，4，2： | 7 |
| 2 | Synthesis, characteriza- tion and photoeatalytic properties of novel zinc germanate nano - materia]显示文摘 | Boppana V B R Hould N D Lobo R F | 2011 | J Solid State Chem2011，184，5： | 1 |
| 3 | Identification of human whole saliva protein components using proteomics显示文摘 | Vitorino R Lobo MJ Ferrer-Correira AJ | | 0，，： | 1 |
| 4 | Inelastic Response of R/C Structures with Viscoelastic Braces显示文摘 | LOBO R F BRACCI J M SHEN K L | 1993 | Earthquake Spectra1993，9，3： | 1 |
| 5 | Colloidal nanoplatelets with two- dimensional electronic structure 显示文摘 | Ithurria S Tessier M D Mahler B Lobo R P S M Du- bertret B Efros A L | 2011 | Nature Materials2011，10，12： | 1 |
| 6 | Systemically administered a2-agonist-in-duced peripheral vasoconstriction in humans显示文摘 | Tallke PO Lobo E Brown R | 2003 | Anesthesiology2003，99，1： | 1 |
| 7 | Evaluation of alternative breeding programs for dual purpose zebu cattie显示文摘 | LOBO R N B MADALENA F E PENNA V M | 2000 | Rev Bras Zootec2000，29，5： | 1 |
| 8 | Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells显示文摘 | Shimono Y Zabala M Cho R W Lobo N Dalerba P Qian D | 2009 | Cell2009，138，： | 1 |
| 9 | Effect of salt and wter balance on recovery of gastrointestinal function after elective colonic resection: a randomized controlled trial 显示文摘 | Lobo D N Bostock K A Neal K R | 2002 | Lancet2002，359，9320： | 1 |
| 10 | Human elimination of phthalate compounds : blood, urine and sweat ( BUS ) study 显示文摘 | Genuis S J Beesoon S Lobo R A | 2012 | Scientific World Journal2012，，61： | 1 |
| 11 | Genetic basis for in vivo daptomycin resistance in enterococci显示文摘 | Arias CA Panesso D McGrath DM Qin X Mojica MF Miller C Diaz L Tran TT Rincon S Barbu EM Reyes J Roh JH Lobos E Sodergren E Pasqualini R Arap W Quinn JP Shamoo Y Murray BE Weinstock GM | | 0，，： | 1 |
| 12 | Variable anchoring of boron in zeolite beta 显示文摘 | Koller H Fild C Lobo R F | 2005 | Micropor Mesopor Mater2005，79，： | 1 |
| 13 | Porous silica via colloid crystallization显示文摘 | Velev O D Jede T A Lobo R F | 1997 | Nature1997，389，： | 1 |
| 14 | Carbon dioxide and nitrogen adsorption on cation-exchanged SSZ-13zeolites显示文摘 | Pham T D Liu Q Lobo R F | 2012 | Langmuir2012，29，2： | 1 |
| 15 | Performanceof new infrared beamline U12IR at the NationalSynchrotron Light Source显示文摘 | Lobo R P Laveigne J D Reitze D H | 1999 | Rev Sci Instrum1999，70，7： | 1 |
| 16 | Isolation of Toxoplas- ma from soil during an out-break of Toxoplasmosis in a rural area in Brazil显示文摘 | Coutinho S G Lobo R Dutra G | 1982 | J Parasitaol1982，68，5： | 1 |
| 17 | Optimizing the aromatic yield and distribution from catalytic fast pyrolysis of biomass over ZSM-5显示文摘 | Foster A J Jae J Cheng Y T Huber G W Lobo R F | | 0，，： | 1 |
| 18 | Porous Silica via Colloidal Crystallization显示文摘 | Velev O D Jede T A Lobo R F | 1997 | Nature1997，，389： | 1 |
| 19 | Porous silica via colloid crystallization显示文摘 | Jede T A Lobo R F | 1997 | Nature1997，389，： | 1 |
| 20 | Microstructured porous silica obtained via colloidal crystal templates 显示文摘 | Velev O D Jede T A Lobo R F | 1998 | Chemistry of Materials1998，10，： | 1 |
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