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| 1 | Hirudotherapy attenuates arthritic pain in patients with various chronic pain syndromes: A retrospective analysis显示文摘Objective: Osteoarthritis is a degenerative disease that affects synovial joints. Micro-injuries of articular structures initiate inflammatory processes, leading to persistent pain. Due to various risk factors,osteoarthritis is often diagnosed in multimorbid patients. This makes pain management one of the key challenges, with a consistent need for new therapeutic strategies. Hence, complementary and integrative methods such as hirudotherapy have become increasingly important, even though their mechanisms of action are not entirely understood.Methods: We retrospectively analyzed the longitudinal effect of a single leech application on osteoarthritic joints in a heterogenic cohort of 24 cases with various chronic pain syndromes. We assessed articular pain intensity ratings and movability of the treated joint after one-time leeching for up to 12 months.We further investigated the effect of hirudotherapy on the systemic pain status and multimodal treatment strategies of the patients.Results: There was a significant reduction in pain intensity ratings at the joint of leech application for up to 12 months after treatment. The improvements in pain intensities were independent of the form of osteoarthritis treated. In addition, we saw a considerable enhancement in local movability of the treated joint. Hirudotherapy did not seem to influence the systemic pain status as well as the previously established individualized multimodal treatment model of the patients.Conclusion: Leeching as an adjuvant therapy has a great potential especially in terms of safety and longterm outcome. | Johannes Loeser Brigitte Layer Christopher Plata Klaus-Maria Perrar Tim Hucho Rebecca Kulbida | 2020 | Journal of Integrative Medicine2020，18，5： | 2 |
| 2 | Beneficial effects of hirudotherapy in a chronic case of complex regional pain syndrome显示文摘We report about hirudotherapy in a patient with chronic complex regional pain syndrome(CRPS) in the right hand. CRPS is a multifactorial disease associated with disabling pain as well as sensory and motor deficits. The optimal therapeutic management is based on personalized multimodal treatment approaches;however, hirudotherapy has not been described in the available literature. To date, we have completed five medicinal leech treatments. Altogether, hirudotherapy led to rapid and substantial relief of symptoms, especially with respect to pain intensity ratings and skin temperature asymmetries. In addition, the patient’s active and passive agility of the affected limb improved obviously. | Rebecca Kulbida Alexander Mathes Johannes Loeser | 2019 | Journal of Integrative Medicine2019，17，5： | 2 |
| 3 | Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cb1-b 显示文摘 | Loeser S Penninger JM | 2007 | Semin hnmunol2007，19，3： | 1 |
| 4 | Ti-based Nano-structure-dendrite Composite with Enhanced Plasticity显示文摘 | G He J Eckert W Loeser L Novel | 2003 | Nature Mater2003，2，1： | 1 |
| 5 | Molecular mechanisms of cartilage destruction in osteoar- thritis显示文摘 | Loeser RF | 2008 | J Musculoskelet Neuronal Interact2008，8，2： | 1 |
| 6 | Aging and osteoarthritis:the role of chondrocyte senescence and aging changes in the cartilage matrix显示文摘 | Loeser RF | | 0，，8： | 1 |
| 7 | Aging processes and the development of osteoarthritis显示文摘 | Loeser RF | 2013 | Curr Opin Rheumatol2013，25，1： | 1 |
| 8 | Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints 显示文摘 | Ekenstedt K J Sonntag W E Loeser R F | 2006 | Arthritis Rheum2006，54，12： | 1 |
| 9 | Testis-sparingsurgery versus radical orchiectomy in patients with Leydigcell tumors 显示文摘 | Loeser A Vergho DC Katzenberger T | 2009 | Urology2009，74，2： | 1 |
| 10 | Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis显示文摘 | Stone AV Loeser RF Vanderman KS | 2014 | Osteoarthritis Cartilage2014，22，2： | 1 |
| 11 | A neurophy siological theory for the painmechanism of tic douloureux 显示文摘 | Calvin WH Loeser JD Howe JF | 1977 | J Pain1977，3，2： | 1 |
| 12 | Modulation of integrin-mediated attachment of chondrocytes to extracellular matrix proteins by cations,retinoic acid,and transforming growth factor-beta显示文摘 | Loeser RF | 1994 | Exp Cell Res1994，211，： | 1 |
| 13 | Prognostic significance of molecular markers and extent of resection in primary glioblastoma patients显示文摘 | Felsberg J Rapp M Loeser S | 2009 | Clin Cancer Res2009，15，21： | 1 |
| 14 | Integrin expression by primary and immortalized human chondrocytes: evidence of a differential role for alphalbetal and alpha2betal integrins in mediating chondrocyte adhesion to type Ⅱ and Ⅵ collagen 显示文摘 | Loeser RF Sadiev S Tan L | 2000 | ] Osteoarthritis Cartilage2000，8，2： | 1 |
| 15 | The role of carbohydrates in the induction of the acrosome reaction in mouse spermatozoa显示文摘 | Loeser CR Lynch C Tulsiani DR | 1999 | Biol Reprod1999，60，3： | 1 |
| 16 | Molecular mechanisms of cartilage destruction:mechanics,inflammatory mediators,and aging collide显示文摘 | Loeser R F | 2006 | Arthritis Rheum2006，54，5： | 1 |
| 17 | Integrin expression by primary and immortalized human chondroeytes: evidence of a differential role for alphalbetal and alpha2betal integrins in mediating chondroeyte adhesion to types Ⅱ and Ⅵ collagen 显示文摘 | Loeser RF Sadiev S Tan L | 2000 | Osteoarthritis Cartilage2000，8，： | 1 |
| 18 | Phantom body pain in paraplegics : evidence for a centran generating mechanism for pain 显示文摘 | Melzack R Loeser JD | 1978 | Pain1978，4，： | 1 |
| 19 | 5-year reoperation rates after different types of lumbar spine surgery显示文摘 | MALTER A D MCNENEY B LOESER J D | 1998 | Spine1998，23，： | 1 |
| 20 | Epidermal RANKL controls regu- latory T-cell numbers via activation of dendritic cells 显示文摘 | Loser K Mehling A Loeser S | 2006 | Nat Med2006，12，12： | 1 |
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