|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 2 | 采用间接复位、钢板固定、不植骨的方法治疗稳定的股骨干髓内假体周围骨折显示文摘背景:间接复位技术相对于较早期的开放复位技术具有能够提高骨愈合率及减少植骨的优势,我们对以间接复位治疗股骨干假体周围骨折的结果进行了研究。
方法:连续对50例稳定的股骨干髓内假体周围骨折(Vancourvr B1型)进行治疗,根据病例记录包括切开复位、间接复位、外侧单钢板固定且不行同种异体或其他植骨。4例术后早期死亡,5例随访时间短,对其余41例(平均年龄72岁)进行了平均24个月的随访,并进行临床和影像学评估。
结果:所有骨折平均12周(7~23周)愈合,对位满意。1例有1根钢丝断裂,2例有1枚螺钉断裂,骨折最终愈合且无明显的内置物松动和对位不良。1例发生围手术期深部感染。41例中30例行走功能恢复到骨折前的状态。
结论:结果证实间接复位骨膜外侧单钢板固定且不进行植骨的方法对于稳定的股骨干髓内假体周围骨折的疗效是应该肯定的。
可信水平:治疗性研究,Ⅳ级,进一步可信度参见作者介绍。 | WILLIAM M. RICCI BRETT R. BOLHOFNER TIMOTHY LOFTUS CHRISTOPHER COX SCOTT MITCHELL JOSEPH BORRELLI JR 董强(译) 马宝通(译) | 2006 | 骨科动态2006，2，1： | 2 |
| 3 | The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America:a systematic review显示文摘 | Loftus EV Jr Schoenfeld P Sandborn WJ | 2002 | Aliment Pharmacol Ther2002，16，1： | 1 |
| 4 | Relationships between disease activity and serum and fecal biomarkers in patients with Crohn' s disease 显示文摘 | Jones J Loftus EV Jr Panaccione R | 2008 | Clin Gastroenterol Hepatol2008，6，11： | 1 |
| 5 | Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus显示文摘 | A. Bourreille A. Ignjatovic L. Aabakken E. Loftus Jr R. Eliakim M. Pennazio Y. Bouhnik E. Seidman M. Keuchel J. Albert S. Ardizzone S. Bar-Meir R. Bisschops E. Despott P. Fortun R. Heuschkel J. Kammermeier J. Leighton G. Mantzaris D. Moussata S. Lo V. Pau | 2009 | Endoscopy2009，，07： | 1 |
| 6 | Amlodipine potentiates metalloproteinase activity and accelerates elastin degradation in a model of aneurysmal disease 显示文摘 | Boyle JR Loftus IM Goodall S | 1998 | Eur J Vasc Endovasc Surg1998，16，5： | 1 |
| 7 | Correlation of C - reactive protein with clinical, endoscopic, histologic, and radiographic activity in innammatory Bowel disease 显示文摘 | Solem C A Loftus E V Jr Tremaine W J et aJ | 2005 | Inflamm Bowel Dis2005，11，： | 1 |
| 8 | Small-bowel imaging in Crohn's disease: a prospective, blinded, 4- way comparison trial显示文摘 | Solem CA Loftus EV Jr Fletcher JG | 2008 | Gastrointestinal Endoscopy2008，68，2： | 1 |
| 9 | Placental transfer and nenonafaleffects epiduraf Sufenfanil and fentanyl administered with bupivacaineduring labor显示文摘 | Loftus JR Hill H Cohen SE | 1995 | Anesthestology1995，83，： | 1 |
| 10 | Relationships between disease activity and serum and fecal biomarkers in patients with Crohn'sdisease 显示文摘 | Jones J Loftus EV Jr Panaccione R | 2008 | Clin Gastroenterol Hepatol2008，6，11： | 1 |
| 11 | Inflammatory bowel disease after liver transplantation for primary sclerosing cholangitisp显示文摘 | Singh S Loftus EV Jr Talwalkar JA | 2013 | Am J Gastroenterol2013，108，9： | 1 |
| 12 | Correlation of C-reactive protein with clinical, endoscopic, histologic and radiographic activity in intlammatory bowel disease显示文摘 | Solem CA Loftus EV Jr Tremains WJ | 2005 | Intlam Bowel Dis2005，11，8： | 1 |
| 13 | Neonatal nasal deformities secondary to nasal continuous positive airway pressure显示文摘 | Loftus BC Ahn J Haddad J Jr | 1994 | Laryngoscope1994，104，81： | 1 |
| 14 | Correlation of C-reactive protein with clinical, endo- scopic, histologic and radiographic activity in inflamma- tory bowel disease显示文摘 | SOLEM C A LOFTUS E V JR TREMAINS W J | 2005 | Inflam Bowel Dis2005，11，： | 1 |
| 15 | The natural historyof corticosteroid therapy for inflammatory bowel disease:a popu-lation-based study显示文摘 | Faubion WA Jr Loftus EV Jr Harmsen WS et a1 | 2001 | Gastroenterology2001，121，2： | 1 |
| 16 | Technology Insight: New Techniques for Imaging the Gut in Patients with IBD显示文摘 | Bruining DH Loftus EV Jr | 2008 | Clin Pract Gastroenterol Hepatol2008，5，3： | 1 |
| 17 | Capsule endoscopy for Crohn's disease:ready for prime time显示文摘 | Loftus EV Jr | 2004 | Clin Gastroenterol Hepatol2004，2，1： | 1 |
| 18 | Correhtion of C-reactiveprotein with clinical,endoscopic,histologie,and radiographic activityin inflammatory bowel disease显示文摘 | Solem CA Loftus EV Jr Tremaine WJ et a1 | 2005 | Inflamm Bowel Dis2005，11，8： | 1 |
| 19 | The natural history of perianal Crohn's disease 显示文摘 | Ingle SB Loftus EV Jr | 2007 | Dig Liver Dis2007，39，： | 1 |
| 20 | Early Crohn disease: a proposed definition for use in disease- modification trials显示文摘 | Peyrin-Biroulet L Loftus EV Jr Colombel JF | 2010 | Gut2010，59，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员