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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Assessment of the effects of ketamine-fenta- nyl combination versus propofol-remifentanil combination for sedation during endoscopic retrograde cholangiopancreatography 显示文摘 | Heidari SM Loghmani P | 2014 | J Res Med Sci2014，19，9： | 1 |
| 3 | Regional alterations in protein expression in the dyssynchronous failing heart显示文摘 | Spragg DD Leclercq C Loghmani M | 2003 | Circulation2003，108，8： | 1 |
| 4 | La3+ and Zr4+ co-doped anatase nano TiO2 by sol-microwave method显示文摘 | SHOJAIE A F LOGHMANI M H | 2010 | Chemical Engineering Journal2010，157，： | 1 |
| 5 | Musculoskeletal symptoms and job satisfaction among office-workers:a cross-sectional study from Iran显示文摘 | Loghmani A Golshiri P Zamani A | 2013 | Acta Med Acad2013，42，： | 1 |
| 6 | Regional alterations in protein expression in the dyssynchronous failing heart显示文摘 | Spragg DD Leclercq C Loghmani M | 2003 | Circulation2003，108，： | 1 |
| 7 | La^3+ and Zr^4+ co-doped anatase nano TiO2 by sol-microwave method显示文摘 | Shojaie A F Loghmani M H | 2010 | Chemical Engineering Journal2010，157，1： | 1 |
| 8 | Regional alterations in protein expression in the dyssynchronous failing heart显示文摘 | Spragg DD Leclercq C Loghmani M | 2003 | Circulation2003，108，： | 1 |
| 9 | Regional alterations in protein expression in the dyssynchronous failing heart显示文摘 | Spragg DD Leclereq C Loghmani M | | 0，，： | 1 |
| 10 | 显示文摘 | Abdollah Fallah Shojaie Mohammad Hassan Loghmani | 2010 | Chemical Engineering Journal2010，157，： | 1 |
| 11 | Assessment of the effects of ketamine-fentanyl combination versus propofol-remifen- tanil combination for sedation during endoscopic retrograde cholangiopancreatography显示文摘 | Heidari SM Loghmani P | 2014 | J Res Med Sci2014，19，9： | 1 |
| 12 | Regional alterations in protein expression in the dyssynchronous failing heart显示文摘 | Spragg DD Leclercq C Loghmani M | 2003 | Circulation2003，108，8： | 1 |
| 13 | Regional alterations in protein expression in the dyssynchronous failing hear 显示文摘 | Spragg DD Leclercq C Loghmani M | 2003 | Circula-tion2003，108，8： | 1 |
| 14 | Regional alterations in protein expression in the dyssynchronous failing heart显示文摘 | Spragg DD Leclercq C Loghmani M | 2003 | Circulation2003，108，8： | 1 |
| 15 | Instrument-assisted cross fiber massage increases tissue perfusion and alters microvascular morphology in the vicinity of healing knee Ligaments显示文摘 | Loghmani MT Warden SJ | 2013 | BMC Complement Altern Med2013，13，： | 1 |
| 16 | Regional alterations in protein expression in the dyssynchronous failing heart显示文摘 | Spragg D Leclercq C Loghmani M | 2003 | Circulation2003，108，： | 1 |
| 17 | Regional alterations in protein expression in the dyssynchronous failing heart显示文摘 | Spragg D D Leclercq C Loghmani M | | 0，，08： | 1 |
| 18 | Regional alterations inprotein expression in the dyssynchronous failing heart显示文摘 | Spragg D Leclercq C Loghmani M | 2003 | Circula-tion2003，108，8： | 1 |
| 19 | Reiter's syndrome in a patient withpolyarthritis and nail involvement 显示文摘 | Zandieh F Loghmani M | 2008 | Iran J Allergy AsthmaImmunol2008，7，3： | 1 |
| 20 | Regional alterations in protein ex- pression in the dyssynchronous failing heart 显示文摘 | Spragg DD Leclercq C Loghmani M | 2003 | Circulation2003，108，： | 1 |
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