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| 1 | Human sperm immobilization effect of Carica papaya seed extracts: an in vitro study显示文摘Aim: To examine if the seed extracts of Carica papaya, which showed antispermatogenic/sperm immobilization properties in animal models, could cause human sperm immobilization in vitro. Methods: Chloroform extract, benzene chromatographic fraction of the chloroform extract, its methanol and ethyl acetate sub-fractions and the isolated compounds from the sub-fractions i.e., ECP 1 & 2 and MCP 1 & 2, of the seeds of Cadca papaya were used at concentrations of 0.1%, 0.5%, 1% and 2%. Sperm motility was assessed immediately after addition of extracts and every 5 minutes thereafter for 30 minutes. Results: There were dose-dependent spermicidal effects showing an instant fall in the sperm motility to less than 20 % at 2 % concentration. Isolated compounds ECP 1 & 2 were more effective inducing a motility of less than 10%. Many of the spermatozoa became vibratory on the spot. Total inhibition of motility was observed within 20 - 25 min at all concentrations of all products. Scanning and transmission electron microscopy revealed deleterious changes in the plasma membrane of the head and mid-piece of spermatozoa. Sperm viability test and the number of abnormal spermatozoa after completion of incubation suggested that the spermatozoa were infertile. The effects were spermicidal but not spermiostatic as revealed by the sperm revival test. Conclusion: The results reveal spermicidal activity in vitro of the seed extracts of Carica papaya. | Nirmal K Lohiya Lalit K Kothari B Manivannan Pradyumna K Mishra Neelam Pathak | 2000 | Asian Journal of Andrology2000，2，2： | 6 |
| 2 | 经番木瓜种子甲醇分馏物长期治疗后大鼠的精子特点和睾丸超微结构显示文摘番木瓜种子的短期避孕效果已经确认,本文旨在研究大鼠长期服用番木瓜种子甲醇分馏物避孕的安全性和避孕机制。连续360天每天给雄性大鼠(n=40)口服番木瓜种子甲醇分馏物50mg kg^-1;对照组大鼠(n=40)给予橄榄油作为赋形剂。停止给药后120天对大鼠恢复情况进行测定。测量精子参数、血清睾酮水平、生育率、睾丸组织学及超微结构、血液学及血清临床化学,以评价番木瓜种子甲醇分馏物的安全性和有效性。大鼠健康状况、器官重量、血液学和临床化学均未改变,体重增加,证明了该长期治疗的安全性。Sertoli细胞中细胞核和细胞质体积减小、细胞核特征正常、胞质器中空泡形成,精母细胞和精子细胞核变性显示出生精受到干扰,这些均说明其避孕机制。Leydig细胞正常。治疗第60天在Sertoli细胞中观察到初始效果,治疗120—240天后精母细胞和精子细胞开始受影响。治疗60天后精子总数和精子存活率显著降低,精子活力完全抑制,精子异常增加,血清睾酮水平正常,不育率达到100%。停止治疗120天后,包括生育率在内的所有发生改变的参数都恢复到对照水平。本研究表明用番木瓜种子甲醇分馏物长期治疗是安全的,其避孕机制是通过对睾丸中精子细胞分化产生影响,可能由Sertoli细胞因素调节。 | Boomi Manivannan Ruchi Mittal Shipra Goyal Abdul S. Ansari Nirmal K. Lohiya | 2009 | Asian Journal of Andrology2009，11，5： | 4 |
| 3 | Sperm motility inhibitory effect of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in langur monkey, Presbytis entellus entellus显示文摘瞄准:为了估计苯的避孕功效,在一种长尾猴的 Carica 番大瓜树的种子的氯仿摘录的色析法的部分胡闹。方法:测试物质在 50 mg/kg 身体重量 / 天被给 p.o 到五只猴子 360 天。控制动物(n= 3 ) 是收到了橄榄油车辆。精子参数作为每世界健康组织标准,精子功能的测试,睾丸和 epididymis 的形态学, haematology,临床的生物化学,浆液睾丸激素和性欲被评估。360 天处理的后面的结束动物从处理被撤退,恢复模式被精液分析和精子估计功能的测试。结果:精子活动性的全部的抑制被观察跟随 60 天继续直到 360 天学习时期的处理。精子计数,百分比生存能力和百分比正常精子给一个激烈的衰落追随者看了 30 天处理。精子形态学显示出占优势的中间的片畸形。精子功能的测试在无菌的范围得分了。睾丸的组织学和超微结构在 Sertoli 房间和细菌房间揭示了 vacuolization。细胞质的细胞器的损失在 spermatocytes 和圆 spermatids 是明显的。对待的动物的 epididymis 的组织学和超微结构比得上控制动物的那些。Hematological 和浆液临床的参数和睾丸激素层次在整个学习时期在控制范围以内波动。恢复是明显的跟随处理退却的 60-120 天。结论:结果建议 Carica 番大瓜树的种子的氯仿摘录的色析法的部分显示出的苯没有不利毒性的避孕功效,通过精子活动性的抑制调停了。 | Nirmal K. Lohiya Boomi Manivannan Shipra Goyal Abdul S. Ansari | 2008 | Asian Journal of Andrology2008，10，2： | 3 |
| 4 | 新型冠状病毒主要蛋白酶6YNQ黄酮类化合物抑制剂的鉴定:一项分子对接研究显示文摘目的新型冠状病毒肺炎(COVID-19)的病原体新型冠状病毒(SARS-CoV-2)是导致最近疫情全球大流行的原因,由于目前尚无针对SARS-CoV-2的有效药物或疫苗,我们研究了黄酮类化合物对抗SARS-CoV-2主要蛋白酶6YNQ的潜力。方法对SARS-CoV-2的主要蛋白酶6YNQ进行计算机模拟研究。结果所选的21种黄酮类化合物中,芦丁结合能(−8.7 kcal/mol)最高,与催化位点结合良好。结论黄酮类化合物对SARS-CoV-2主要蛋白酶6YNQ有抑制作用,这些计算模拟研究支持了黄酮类化合物可能有助于COVID-19治疗的假设。 | SUMIT Arora GOVIND Lohiya KESHAV Moharir SAPAN Shah SUBHASH Yende | 2020 | Digital Chinese Medicine2020，3，4： | 2 |
| 5 | Integrated Inventory and Transportation Mode Selection: A Service Parts Logistics System 显示文摘 | KUTANOGLU E LOHIYA D | 2008 | Transportation Research Part E2008，44，5： | 1 |
| 6 | Corneal astigmatism correction with opposite clear corneal incisions or single clear cornealin - cision: comparative analysis 显示文摘 | Khokhar S Lohiya P Murngiesan V | 2006 | J Cataract Refract Surg2006，32，9： | 1 |
| 7 | Integrated inventory and transportation mode selection:a service parts logistics system显示文摘 | Kutanoglu E Lohiya D | 2008 | Transportation Research2008，44，5： | 1 |
| 8 | Role of phenytoin in healing large abscess cavities显示文摘 | Lodha SC Lohiya ML Vyas MCR | | 0，，01： | 1 |
| 9 | Toxicological investigations on the methanol sub-fraction of the seeds of Carica papaya as a male contraceptive in albino rats显示文摘 | Nirmal K. Lohiya Boomi Manivannan Shipra Garg | 2006 | Reproductive Toxicology2006，，3： | 1 |
| 10 | Corneal astigmatism correction with opposite clear corneal incision or single clear corneal incision: Comparative analysis显示文摘 | Khokhar S Lohiya P Murugiesn V | 2006 | J Cataract Refract Surg2006，32，9： | 1 |
| 11 | Integrated inventory and transportation mode selection : a service parts logistics system 显示文摘 | KUTANOGLU E LOHIYA D | 2008 | Transportation Research2008，44，5： | 1 |
| 12 | The role of phenytoin in the treatment of large abscess cavities显示文摘 | Lodha S C Lohiya M L Vyas M C R | 1991 | BrJ Surg1991，78，1： | 1 |
| 13 | Pretibial myxedema without oph- thalmopathy: an initial presentation of Graves' disease 显示文摘 | Lohiya S Lohiya V Stahl EJ | 2013 | Am J Med Sci2013，346，1： | 1 |
| 14 | Corneal astigmatism correction with opposite dear corneal incisions or single clear corneal incision:comparative analysis显示文摘 | Khokhar S Lohiya P Murugiesan V | 2006 | J Cataract Refract Surg2006，32，9： | 1 |
| 15 | Purified neem ( Azadirachta indica ) seed extracts (Praneem) abrogate pregnancy in primates显示文摘 | Sutapa Mukherjee N.K. Lohiya Rahul Pal M.G. Sharma G.P. Talwar | 1996 | Contraception1996，，6： | 1 |
| 16 | Integrated inventory and transportation mode selection: a service parts logis- tics system 显示文摘 | Kutanoglu E Lohiya D | 2008 | Transportation Research Part E: Logis- tics and Transportation Review2008，44，5： | 1 |
| 17 | Pretibial Myxedema Without Ophthalmopathy: An Initial Presentation of Graves? Disease显示文摘 | Sheela Lohiya Vipin Lohiya Elizabeth J. Stahl | 2013 | The American Journal of the Medical Sciences2013，，1： | 1 |
| 18 | Corneal astigmatism correction with opposite clear corneal incision or single clear corneal incision:Comparative analysis显示文摘 | Khokhar S Lohiya P Murugiesan V | 2006 | J Cataract Refract Surg2006，32，9： | 1 |
| 19 | Real-time scheduling algorithms for wireless sensor network显示文摘 | HARKUT D G ALI M S LOHIYA P | 2014 | Circuits and systems:An International Journal2014，1，1： | 1 |
| 20 | Anti-inflammatory activity of alkanoids and triterpenoids from trichodesma amplexicaule roth显示文摘 | SINGH B SAHU P M LOHIYA R K | 2006 | Phytomedicine2006，13，3： | 1 |
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