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	题名	作者	年代	出处	被引量
1	Translational pain research: Evaluating analgesic effect in experimental visceral pain models显示文摘Deep visceral pain is frequent and presents major challenges in pain management, since its pathophysiology is still poorly understood. One way to optimize treatment of visceral pain is to improve knowledge of the mechanisms behind the pain and the mode of action of analgesic substances. This can be achieved through stand-ardized experimental human pain models. Experimental pain models in healthy volunteers are advantageous for evaluation of analgesic action, as this is often diff icult to assess in the clinic because of confounding factors such as sedation, nausea and general malaise. These pain models facilitate minimizing the gap between knowledge gained in animal and human clinical studies. Combining experimental pain studies and pharmacokinetic stud- ies can improve understanding of the pharmacokinetic-pharmacodynamic relationship of analgesics and, thus, provide valuable insight into optimal clinical treatment of visceral pain. To improve treatment of visceral pain, it is important to study the underlying mechanisms of pain and the action of analgesics used for its treatment. An experimental pain model activates different modalities and can be used to investigate the mechanism of action of different analgesics in detail. In combination with pharmacokinetic studies and objective assessment such as electroencephalography, new information re-garding a given drug substance and its effects can be obtained. Results from experimental human visceral pain research can bridge the gap in knowledge between animal studies and clinical condition in patients suffering from visceral pain, and thus constitute the missing link in translational pain research.	Anne Estrup Olesen Trine Andresen Lona Louring Christrup Richard N Upton	2009	World Journal of Gastroenterology2009，15，2：	3
2	Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD显示文摘	Lonas D A Silverman E K Edwards L D	2009	Eur Respir J2009，34，1：	1
3	A comparative study of oxycodone and morphine in a multi-modal,tissue-differentiated experimental pain model显示文摘	CAMILLA S LONA LC SOREN DA	2006	Pain2006，123，1：	1
4	The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy:a randomized controlled trial显示文摘	Ame Christensen Lona Louring Christrup Paul Erik Fabricius	2010	Journal of Hypertension2010，，28：	1
5	The spectrum of SCN1A - related infantile epileptic encephalopathies 显示文摘	Harkin LA Mcmahon JM Lona X	2007	Brain2007，130，3：	1
6	Analysis of the interference pattern in patients with muscular dystrophy 显示文摘	Eseobar-Cedillo RE Miranda A Lona S	2004	Rev Neurol2004，39，6：	1
7	Optimizing panose production by modeling and simulation using factorial design and surface response analysis显示文摘	Rodrigues S Lona L M F Franco T T	2006	Food Engineering2006，75，：	1
8	Urinary Tract Infections in Older Women显示文摘	Lona Mody Manisha Juthani-Mehta	2014	The Journal of the American Medical Associatatian2014，311，8：	1
9	Introduction of a waterless alcohol-based hand rub in along-term-care facility显示文摘	Lona M Shelly AM Rongjun S at al	2003	Infect Control Hosp Epidemiology2003，24，3：	1
10	Heterogeneous modeling for fluidized -bed polymerization reactor显示文摘	Liliane M F Lona	2001	Chemical Engineering Science2001，，56：	1
11	Fluidized-bed reactor modeling for polyethylene production显示文摘	Liliane M F Lona	2001	Jorunal of Applied Polymer Science2001，，81：	1
12	Heterogeneous modeling for fluidized -bed polymerization reactor显示文摘	Liliane M F Lona	2001	Chemical Engineering Science2001，，56：	1
13	Introduction of a water-less alcohol-based hand mb in a long-term-care facility显示文摘	Lona M Shelly AM Rongjun S	2003	Infect Control Hosp Epidemiology2003，24，3：	1
14	Heterogeneous modeling of fluidized-bed polymerization reactors:Influence of mass diffusion into the polymer particle显示文摘	Liliane M F Lona	2002	Computers and Chemical Engineering2002，，26：	1
15	congenital hydronephrosis:prenatal diagnosis and epidemiology in Europe显示文摘	Garne E Lonae M Wellesley D	2009	J Pediatr Urol2009，5，1：	1
16	Aerodynamics of a badminton shuttlecock显示文摘	Post S L McLachlan J Lonas T	2010	ASME International Mechanical Engineering Congress and Exposition2010，7，：	1
17	Introducti on of a water-less alcohol-based hand rub in a long-term-care facility显示文摘	Lona M Shelly AM Rongjun S	2003	InfectControl Hosp Epidemiology2003，24，3：	1
18	Functional Disability and Nursing Resource Use Are Predictive of Antimicrobial Resistance in Nursing Homes显示文摘	Lillian Min Andrzej Galecki Lona Mody	2015	J Am Geriatr Soc2015，，：	1
19	Infection of human dendritic cells with a Mycobacterium tuberculosis sigE mutant stimulates production of high levels of interleukin - 10 but low levels of CXCL10 : impact on the T-cell respome显示文摘	GIACOMINI E SOTOLONGO A LONA E	2006	Infection and Immunity2006，74，6：	1
20	The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial 显示文摘	Arne Christensen Lona Louring Christrup Paul Erik Fabrlcius	2010	Journal of Hypertension2010，28，：	1

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