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您的检索式：作者名="Longgui Zhang"
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| 1 | Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery显示文摘α-Cyclodextrin/poly(ethylene glycol)(α-CD/PEG) polyrotaxane nanoparticles were prepared via a self-assembly method. Anticancer drug methotrexate(MTX) was loaded in the nanoparticles. The interaction between MTX and polyrotaxane was investigated. The formation, morphology, drug release and in vitro anticancer activity of the MTX loaded polyrotaxane nanoparticles were studied. The results show that the MTX could be efficiently absorbed on the nanoparticles, and hydrogen bonds were formed between MTX andα-CDs. The typical channel-type stacking assembly style of polyrotaxane nanoparticles was changed after MTX was loaded. The mean diameter of drug loaded polyrotaxane nanoparticles were around 200 nm and the drug loading content was as high as about 20%. Drug release profiles show that most of the loaded MTX was released within 8 hours and the cumulated release rate was as high as 98%. The blank polyrotaxane nanoparticles were nontoxicity to cells. The in vitro anticancer activity of the MTX loaded polyrotaxane nanoparticles was higher than that of free MTX. | Longgui Zhang Ting Su Bin He Zhongwei Gu | 2014 | Nano-Micro Letters2014，6，2： | 0 |
| 2 | Role of Conformational Entropy in Complex Macromolecular Systems显示文摘Conformation is the key to revealing the physical characteristics of macromolecular systems and receives tremendous interest from the fields of polymer physics and biological materials.The conformational entropy,related to the number of conformations of the macromolecule,plays a predominant role in the structural formation,transition,and dynamics of macromolecular systems.In this review,we present a comprehensive overview of the research,development and applications of the conformational entropy in complex macromolecular systems.We begin by discussing the physical origin of the conformational entropy based on statistical mechanics of macromolecules in classical polymer physics,and then introduce the recent progress on the predictive modeling of the conformational entropy,associated with a variety of typical macromolecular systems.Furthermore,we also highlight several principles and rules,which have been harnessed to manipulate the structural organization of complex macromolecular systems through the conformational entropy.We anticipate that this review will further promote fundamental research in polymer physics,and offer intriguing prospects for applications in complex macromolecular systems including biomacromolecules,grafted nanoparticles,and polymer nanocomposites. | DAI Xiaobin WAN Hai-Xiao ZHANG Xuanyu WEI Wenjie CHEN Wenlong ZHANG Longgui LI Juan YAN Li-Tang | 2023 | Chemical Research in Chinese Universities2023，39，5： | 0 |
| 3 | Highly Stable Perovskite Solar Cells by Reducing Residual Water-Induced Decomposition of Perovskite显示文摘Residual water-induced decomposition is one of the dominant reasons for the decay of power conversion efficiency (PCE) in perovskite solar cells (Pero-SCs). To solve this problem, we introduce traces amount of sodium hyaluronate (SH) into the perovskite active layer to reduce the remaining water during the preparation of perovskite films. Unlike the traditionally adopted passive protection of perovskite from exterior water by low surface energy coatings, this study provides active control of the interior water by the addition of a water adsorbent into the perovskite films. The encapsulated Pero-SCs with SH retain approximately 70% of their initial PCE in 4000 h, while those without SH retain 32% of their initial PCE in 1000 h under the dark and ambient atmosphere. The unencapsulated Pero-SCs with SH stored in N2 atmosphere maintain over 94% of the initial PCE in 3000 h at room temperature away from light and remain over 88% of the initial PCE in 2000 h even the devices are heated to 70 °C. It has been proven that the improved stability is mainly due to the well-controlled residual water in perovskite films. Concomitantly, the PCE of p-i-n solar cells based on (FAPbI3)0.85(MAPbBr3)0.15 is improved from 19.34% to 21.54%. | Xudong Yang Wenxi Ji Qiaoyun Chen Rui Su Longgui Zhang Ailian Wang Taoyi Zhang Yi Zhou Bo Song | 2023 | Chinese Journal of Chemistry2023，41，13： | 0 |
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