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您的检索式：作者名="Longze Sha"
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| 1 | Comparison ofβ-Amyloid Plaque Labeling Methods:Antibody Staining,Gallyas Silver Staining,and Thioflavin-S Staining显示文摘Objective To evaluate senile plaque formation and compare the sensitivity of three differentβ-amyloid(Aβ)labeling methods(antibody staining,Gallyas silver staining,and thioflavin-S staining)to detect Aβdeposition.Methods APPswe/PSEN1dE9 transgenic mice(APP/PS1)of different ages were used to examine spatiotemporal changes in Aβplaque deposition.Antibody staining,Gallyas silver staining,and thioflavin-S staining were used to detect Aβplaque deposition in the same brain region of adjacent slices from model mice,and the results were compared.Results With aging,Aβplaques first appeared in the cortex and then the deposition increased throughout the whole brain.Significantly greater plaque deposition was detected by 6E10 antibody than that analyzed with Gallyas silver staining or thioflavin-S staining(P<0.05).Plaque deposition did not show significant difference between the APP/PS1 mice brains assayed with Gallyas silver staining and ones with thioflavin-S staining(P=0.0033).Conclusions The APP/PS1 mouse model of Alzheimer’s disease could mimick the progress of Aβplaques occurred in patients with Alzheimer’s disease.Antibody detection of Aβdeposition may be more sensitive than chemical staining methods. | Xinze Shi Xuan Wei Longze Sha Qi Xu | 2018 | Chinese Medical Sciences Journal2018，33，3： | 1 |
| 2 | Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy显示文摘 | Longze Sha Xiaofeng Wu Yuan Yao Bo Wen Jing Feng Zhiqiang Sha Xueqin Wang Xiaoliang Xing Wanchen Dou Liri Jin Wenting Li Naili Wang Yan Shen Jinhui Wang Liwen Wu Qi Xu | 2014 | Molecular Neurobiology2014，，2： | 1 |
| 3 | Postzygotic mosaic mutations in autism spectrum disorder and other neuropsychiatric disorders显示文摘Autism,or autism spectrum disorder(ASD),refers to a range of neurodevelopmental disorders characterized by:(1)impaired social interaction,(2)impaired verbal and non-verbal communication,and(3)restricted and repetitive behavior[1].Although typically not diagnosed until the age of 3,symptoms can present during infancy.Early intervention with behavioral therapies has been shown to improve learning,communication,and social skills. | Longze Sha Qi Xu | 2017 | Science Bulletin2017，62，24： | 0 |
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