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| 1 | 抗乙酰胆碱受体单克隆抗体A7诱导实验性自身免疫性重症肌无力作用显示文摘目的探讨抗乙酰胆碱受体单克隆抗体A7(抗-AChR mAb A7)对实验性自身免疫性重症肌无力(EAMG)的作用. 方法经Lewis大鼠腹腔注射5 mL 20倍浓缩的含抗-AChR mAb A7培养上清液,建立EAMG被动转输模型.对照组经腹腔注射同体积的PBS.每8 h监测体重和临床症状评分.48 h后处死实验动物.采用放射免疫法检测AChR,并计算出AChR损失率.结果抗-AChR mAb A7诱导的EAMG模型AChR损失率高达24.3%~45.2%,而且AChR损失率与临床症状评分相关(r=0.74, P<0.01).抗-AChR mAb A7攻击位点在终板的AChR上.结论抗-AChR mAb A7可用于诱导EAMG模型及有关研究. | 张旭 Mario Losen Marc De Baets | 2005 | 中国神经免疫学和神经病学杂志2005，12，2： | 5 |
| 2 | In vivo eleetroporation of the central nervous system: A non-viral approach for targeted gene delivery 显示文摘 | De Vry J Martinez-Martinez P Losen M | 2010 | Prog Neurobiol2010，92，3： | 1 |
| 3 | Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ显示文摘 | Gaisa NT Tilki D Losen I | 2008 | Hum Pathol2008，39，8： | 1 |
| 4 | 受体相关蛋白对实验性自身免疫性重症肌无力大鼠乙酰胆碱受体的作用显示文摘目的:探讨受体相关蛋白(Rapsyn)对实验性自身免疫性重症肌无力(EAMG)动物终板乙酰胆碱受体的作用。方法:用基因工程的方法制备提取pcDNA-Rapsyn,并将其注入动物肌肉左大腿外侧,右大腿相应部位注射相同剂量的空白质粒(Vector)以方波刺激使其进入细胞膜内,2w后用单克隆抗体35(mAb35)诱导出EAMG模型并进行症状评估,mAb35诱导48h后取双大腿外侧肌,用放射免疫法检测AChR,并计算出AChR的损失率。结果:在EAMG模型中,被pcDNA-Rapsyn预处理的肌肉AChR损失率明显低于未经处理的肌肉。结论:Rapsyn蛋白对EAMG模型的AChR有保护作用。 | 张旭 Mario Losen Marc De Baets | 2003 | 温州医学院学报2003，33，3： | 1 |
| 5 | Deletion of Trp- 557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors 显示文摘 | WARDELMANN E LOSEN I HANS V | 2003 | lnt J Cancer2003，106，6： | 1 |
| 6 | The effect of plasma from muscle-specific tyrosine kinase myasthenia patients on regenerating endplates 显示文摘 | Ter Beek WP Martinez-Martfnez P Losen M | 2009 | Am J patbol2009，175，4： | 1 |
| 7 | Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis显示文摘 | Losen M Stassen MH Martinez-Martinez P | 2005 | Brain2005，128，10： | 1 |
| 8 | In- creased expression of rapsyn in muscles prevents acetylcho- line receptor loss in experimental autoimmune myasthenia gravis显示文摘 | Losen M Stassen MH Martinez Martinez P | 2005 | Brain2005，128，10： | 1 |
| 9 | Immunoregulation in experi- mental autoimmune myasthenia gravis -about T cells, antibodies,and endplates显示文摘 | De Baets M Stassen M Losen M | 2003 | Ann N Y Acad Sci2003，，998： | 1 |
| 10 | Increased expression of rapsyn in muscles prevents aeetylcholine receptor loss in experimental autoimmune myasthenia gravis显示文摘 | Losen M Stassen MH Martinez Martinez P | 2005 | Brain2005，128，： | 1 |
| 11 | Treatment of my- asthenia gravis by preventing acetyleholine receptor modulation 显示文摘 | Losen M Martinez-Martinez P Phernambueq M | 2008 | Ann NY Acad Sci2008，1132，1： | 1 |
| 12 | Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4显示文摘 | Jan J.G.M. Verschuuren Maartje G. Huijbers Jaap J. Plomp Erik H. Niks Peter C. Molenaar Pilar Martinez-Martinez Alejandro M. Gomez Marc H. De Baets Mario Losen | 2013 | Autoimmunity Reviews2013，，9： | 1 |
| 13 | The features of myasthe- nia gravis with autoantibodies to MuSK显示文摘 | Lavrnic D Losen M Vujic A | 2005 | J Neurol Neuro surg Psychiatry2005，，10： | 1 |
| 14 | Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange 显示文摘 | VAN DER NEUT KOLFSCHOTEN M SCHUURtVIAN J LOSEN M | 2007 | Science2007，317，5844： | 1 |
| 15 | Anti- inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange 显示文摘 | van der Neut Kolfschoten M Schuurman J Losen M | 2007 | Science2007，317，： | 1 |
| 16 | Increased expression of raspy in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis显示文摘 | Losen M Stassen MH Martinez-Martinez P | 2005 | Brain2005，128，10： | 1 |
| 17 | Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors显示文摘 | Wardelmann E Losen I Hans V | 2003 | Int J Cancer2003，106，6： | 1 |
| 18 | In vivo electro potation of the central nervous system: a non-viral approach for targeted gene delivery 显示文摘 | De Vry J Martinez Martlnez P Losen M | 2010 | Prog Neurobiol2010，92，3： | 1 |
| 19 | Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies,nicotinic acetylcholine receptor conformation maturation,and agonist sensitivity显示文摘 | Luo J Taylor P Losen M | | 0，，： | 1 |
| 20 | Complications of laparoscopic interventions in urology 显示文摘 | Fahlenkamp D Losening SA Turk J | 1996 | Urologe A1996，35，3： | 1 |
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