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119篇 您的检索式：作者名="Louis D A"

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	题名	作者	年代	出处	被引量
1	Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF.	Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz	2012	Hepatobiliary & Pancreatic Diseases International2012，11，4：	3
2	Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘	Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern	1996	Cell1996，，3：	2
3	Tumor necrosis factor(TNF) gene polymorphism influences TNF-alpha production in lipoplysaccharide(LPS)-stimulated whole blood cell culture in healthy humans显示文摘	Louis E Franchimont D Piron A	1998	Clin Exp Immunol1998，113，3：	1
4	Neuroendocrine pharmacology of stress显示文摘	Gonzalo A Carrasco Louis D Van de Kar	2003	European Journal of Pharmacology2003，，1：	1
5	Tumor necrosis factor gene polymorphism influences TNF alpha produc-tion in LPS-stimulated whole blood cell culture in healthy humans显示文摘	Louis E Franchimont D Piron A		0，，3：	1
6	Expression of c-Myc protein in skin and synovium in psoriasis and psoriatic arthritis显示文摘	Osterland C K Wilkinson R D St Louis E A	1990	Clin Exp Rheumatol1990，8，2：	1
7	Finding structure in home videos by probabilistic hierarchical clustering 显示文摘	Perez D G Loui A Sun M T	2003	IEEE Transactions on Circuits and Systems for Video Technology2003，13，6：	1
8	The chemical evolution of Precambrian seawater: Evidence from REEs in banded iron formations显示文摘	Louis A D Jacobsen S B	1990	Geochimica et Cosmochimica Acta1990，54，：	1
9	Identification and expression cloning of a leptin receptor,OB-R显示文摘	Tartaglia Louis A Mariene D Xun Weng	1995	Cell1995，83，：	1
10	Neuroendoerine pharmacology of stress 显示文摘	Gonzalo A C Louis D Van de Kar	2003	European Journal of Pharmacology2003，463，：	1
11	Tumor necrosis factor (TNF)gene polymorphism influences TNF-alpha production in lipopolysaccharde (LPS)stimulated whole blood cell culture in healthy human显示文摘	Louis E Franchimont D Piron A	1998	J Clin Exp Immunol1998，113，3：	1
12	The strontium isotopic budget of Himalayan rivers in Nepal and Bangladesh显示文摘	Albert G Christian F L Louis A D	1998	Geochimica et Cosmoehimica Acta1998，63，：	1
13	Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS) stimulated whole blood cell culture in healthy humans 显示文摘	Louis E Franchimont D Piron A	1998	Clin Exp Immune1998，113，3：	1
14	Expression of three cell adhension mole cules in bladder carcinomas:correlation with pathological features 显示文摘	Mialhe A Louis J Pasquier D	1997	Anal cell pathol1997，13，：	1
15	Tumor necrosis factor(TNF)gene polymorphism influences TNF-alpha production in lipopolysaccharide(LPS)-stimulated whole blood cell culture in healthy humans显示文摘	Franchimont D Piron A	1998	Clin Exp Immunol1998，113，3：	1
16	Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans显示文摘	Louis E Franchimont D Piron A	1998	Clin Exp Immunol1998，113，3：	1
17	International society of neu- ropathology-haarlem consensus guidelines for nervous system tumor classification and grading显示文摘	Louis D N Perry A Burger P	2014	Brain Pathol2014，24，5：	1
18	Tumor necrosis factor (TNF) gene polymorphism influences TNF-αlpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy human显示文摘	Franchimont D Piron A	1998	J Clin Exp Immunol1998，113，3：	1
19	Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans显示文摘	Louis E Franchimont D Piron A	1998	Clin Exp Immunol1998，113，3：	1
20	Neuroendocrine pham-lacology of stress显示文摘	Gonzalo A C Louis D Van de Kar	2003	European Journal of Pharmacology2003，46，3：	1

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