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| 1 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 2 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 3 | Challenges toward standardizatio of islet isolation technology 显示文摘 | RICORDI C LAKEY JR HERING BJ | 2001 | Transplant Proc2001，33，12： | 1 |
| 4 | Lipophilic statins preventmatrix metalloproteinase-mediated cartilage collagen breakdown by inhib-iting protein geranylgeranylation显示文摘 | Barter M J Hui W Lakey R L | 2010 | Ann Rheum Dis2010，69，21： | 1 |
| 5 | Islet transplantation inseven patients with type 1 diabetes mellitus using a glucocorti-coid-free immunosuppressive regimen显示文摘 | Shapiro AM Lakey JR Ryan EA | 2000 | N Engl J Med2000，343，4： | 1 |
| 6 | Macromolecular or-ganisation of recombinant Yersinia pestis F1 antigen and the effectof structure on immunogenicity显示文摘 | Miller J Williamson E D Lakey J H | 1998 | FEMS Immunol Med Micro-biol1998，21，3： | 1 |
| 7 | 显示文摘 | Shapiro A Lakey J Ryan E | 2000 | N Engl J Med2000，343，： | 1 |
| 8 | Combination therapy with glucagomlike peptide and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodefi- eient diabetic mice显示文摘 | Suarez-Pinzon WL Lakey JR Rabinovitch A | 2008 | Cell Transplant2008，17，6： | 1 |
| 9 | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen显示文摘 | SHAPIRO A M LAKEY J R RYAN E A | 2000 | N Engl J Med2000，343，4： | 1 |
| 10 | Islet transplantation in patients with diabetes using glucocorticoid 2 free immunosuppression显示文摘 | Shapiro AM Lakey JR Ryan E | 2000 | N Eng J Med2000，343，7： | 1 |
| 11 | Islet transplantation in seven patients with type I diabetes mellitus using a glucocorti- coid-free immunosuppressive regimen 显示文摘 | Shapiro J Lakey JRT Ryan LEA | 2000 | The New England Journal of Medicine2000，343，4： | 1 |
| 12 | Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA显示文摘 | KORSHUNOVA Y MALONEY R K LAKEY N | 2008 | Genome Res2008，18，1： | 1 |
| 13 | Titin antibodies in myasthenia gravis:identification of a major immunogenic region of titin显示文摘 | Gautel M A Lakey D P Barlow Z | 1993 | Neurology1993，43，： | 1 |
| 14 | Strategic opportunities in clinical islet transplantation显示文摘 | Shapiro AM Lakey JR PatyBW | 2005 | Transplantation2005，79，4： | 1 |
| 15 | Expression of proteins using the third domain of the Escherichia coli periplasmic-protein TolA as a fusion partner显示文摘 | Anderluh G Gokce I Lakey JH | 2003 | Protein Expr Purif2003，28，1： | 1 |
| 16 | Comparative analysis of the QUTR transcription repressor protein and the three Cterminal domains of the pentafunctional AROM enzyme显示文摘 | LAMB H K MOORE J D LAKEY J H | 1996 | Biochemical Journal1996，313，： | 1 |
| 17 | How people make support judgment:individual differences in the traits used to infer supportiveness in others显示文摘 | LUTZ C J LAKEY B | 2001 | J Pers Soc Psychol2001，81，6： | 1 |
| 18 | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen显示文摘 | Shapiro AM Lakey JR Ryan EA | 2000 | N Engl J Med2000，343，4： | 1 |
| 19 | Successful islet transplantation: continued insulin reserve provide long- term glycemic control显示文摘 | Ryan EA lakey JR Paty BW | 2002 | Diabetes2002，51，： | 1 |
| 20 | Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen显示文摘 | Shapiro AMJ Lakey JRT Ryan EA | 2000 | N Eng J Med2000，343，4： | 1 |
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