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1篇 您的检索式：作者名="Louis Rony"

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		题名	作者	年代	出处	被引量
	1	Microarchitecture of titanium cylinders obtained by additive manufacturing does not influence osseointegration in the sheep显示文摘Large bone defects are a challenge for orthopedic surgery.Natural(bone grafts)and synthetic biomaterials have been proposed but several problems arise such as biomechanical resistance or viral/bacterial safety.The use of metallic foams could be a solution to improve mechanical resistance and promote osseointegration of large porous metal devices.Titanium cylinders have been prepared by additive manufacturing(3D printing/rapid prototyping)with a geometric or trabecular microarchitecture.They were implanted in the femoral condyles of aged ewes;the animals were left in stabling for 90 and 270 days.A double calcein labeling was done before sacrifice;bones were analyzed by histomorphometry.Neither bone volume,bone/titanium interface nor mineralization rate were influenced by the cylinder’s microarchitecture;the morphometric parameters did not significantly increase over time.Bone anchoring occurred on the margins of the cylinders and some trabeculae extended in the core of the cylinders but the amount of bone inside the cylinders remained low.The rigid titanium cylinders preserved bone cells from strains in the core of the cylinders.Additive manufacturing is an interesting tool to prepare 3D metallic scaffolds,but microarchitecture does not seem as crucial as expected and anchoring seems limited to the first millimeters of the graft.	Louis Rony Eric Aguado Bruno Verlee Florence Pascaretti-Grizon Daniel Chappard	2021	Regenerative Biomaterials2021，8，4：	0

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