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| 1 | Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma显示文摘Hepatocellular cancer ranks fifth among cancers and is related to chronic viral hepatitis, alcohol abuse,steatohepatitis and liver autoimmunity. Surgical resection and orthotopic liver transplantation have curative potential, but fewer than 20% of patients are suitable candidates. Interventional treatments are offered to the vast majority of patients. Radiofrequency(RFA) and microwave ablation(MWA) are among the therapeutic modalities, with similar indications which include the presence of up to three lesions, smaller than 3 cm in size, and the absence of extrahepatic disease. The therapeutic effect of both methods relies on thermal injury, but MWA uses an electromagnetic field as opposed to electrical current used in RFA. Unlike MWA, the effect of RFA is partially limited by the heat-sink effect and increased impedance of the ablated tissue. Compared with RFA, MWA attains a more predictable ablation zone, permits simultaneous treatment of multiple lesions, and achieves larger coagulation volumes in a shorter procedural time. Major complications of both methods are comparable and infrequent(approximately 2%-3%), and they include haemorrhage, infection/abscess, visceral organ injury, liver failure, and pneumothorax. RFA may incur the additional complication of skin burns. Nevertheless, there is no compelling evidence for differences in clinical outcomes, including local recurrence rates and survival. | Loukia S Poulou Evanthia Botsa Ioanna Thanou Panayiotis D Ziakas Loukas Thanos | 2015 | World Journal of Hepatology2015，7，8： | 37 |
| 2 | YODA-HSP90 Module Regulates Phosphorylation-Dependent Inactivation of SPEECHLESS to Control Stomatal Development under Acute Heat Stress in Arabidopsis显示文摘Stomatal ontogenesis,patterning,and function are hallmarks of environmental plant adaptation,especially to conditions limiting plant growth,such as elevated temperatures and reduced water availability.The specification and distribution of a stomatal cell lineage and its terminal differentiation into guard cells require a master regulatory protein phosphorylation cascade involving the YODA mitogen-activated protein kinase kinase kinase.YODA signaling results in the activation of MITOGEN-ACTIVATED PROTEIN KINASEs(MPK3 and MPK6),which regulate transcription factors,including SPEECHLESS(SPCH).Here,we report that acute heat stress affects the phosphorylation and deactivation of SPCH and modulates stomatal density.By using complem entary molecular,genetic,biochemical,and cell biology approaches,we provide solid evidence that HEAT SHOCK PROTEINS 90(HSP90s)play a crucial role in transducing heat-stress response through the YODA cascade.Genetic studies revealed that YODA and HSP90.1 are epistatic,and they likely function linearly in the same developmental pathway regulating stomata formation.HSP90s interact with YODA,affectits cellular polarization,and modulate the phosphorylation of downstream targets,such as MPK6 and SPCH,under both normal and heat-stress conditions.Thus,HSP90-mediated specification and differentiation of the stomatal cell lineage couples stomatal development to environmental cues,providing an adaptive heat stress response mechanism in plants. | Despina Samakovli Tereza Ticha Tereza Vavrdova Miroslav Ovecka Ivan Luptovciak Veronika Zapletalova Anna Kucharova Pavel Krenek Yuliya Krasylenko Theoni Margaritopoulou Loukia Roka Dimitra Milioni George Komis Polydefkis Hatzopoulos Jozef Samaj | 2020 | Molecular Plant2020，13，4： | 9 |
| 3 | Removal of trivalent samarium from aqueous solutions by activated biochar derived from cactus fibres显示文摘The efficiency of activated biochar fibres obtained from Opuntia Ficus Indica regarding the sorption of trivalent samarium(Sm(III)) from aqueous solutions was investigated by batch experiments. The effect of various physicochemical parameters(e.g. p H, initial metal concentration, ionic strength, temperature and contact time) on the Sm(III) adsorption was studied and the surface species were characterized by FTIR spectroscopy prior to and after the lanthanide sorption. The experimental results showed that the activated biochar fibres possessed extraordinary sorption capacity for Sm(III) in acidic solutions(qmax=90 g/kg, p H 3.0) and near neutral solutions(qmax=350 g/kg, p H 6.5). This was attributed to the formation of samarium complexes with the surface carboxylic moieties, available in high density on the lamellar structures of the bio-sorbent. | Loukia Hadjittofi Styliana Charalambous Ioannis Pashalidis | 2016 | Journal of Rare Earths2016，34，1： | 6 |
| 4 | Transfer of Heavy Metal Contaminants from Animal Feed to Animal Products显示文摘 | Christos Makridis Christos Svamas Nikolaos Rigas Nikolaos Gougoulias Loukia Roka Stefanos Leontopoulos | 2012 | Journal of Agricultural Science and Technology(A)2012，2，1： | 2 |
| 5 | Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis显示文摘 | Stefan Leucht Andrea Cipriani Loukia Spineli Dimitris Mavridis Deniz ?rey Franziska Richter Myrto Samara Corrado Barbui Rolf R Engel John R Geddes Werner Kissling Marko Paul Stapf Bettina L?ssig Georgia Salanti John M Davis | 2013 | The Lancet2013，，： | 1 |
| 6 | Comparison of ISO- GUM and Monte Carlo methods for the evaluation of measurement uncertainty: Application to direct cadmium measurement in water byGFAAS 显示文摘 | Dimitrios T Loukia M Sotirios K | 2011 | Talanta2011，83，5： | 1 |
| 7 | Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis显示文摘 | Stefan Leucht Andrea Cipriani Loukia Spineli Dimitris Mavridis Deniz ?rey Franziska Richter Myrto Samara Corrado Barbui Rolf R Engel John R Geddes Werner Kissling Marko Paul Stapf Bettina L?ssig Georgia Salanti John M Davis | 2013 | The Lancet2013，，： | 1 |
| 8 | Image-Guided Radiofrequency Ablation (RFA) of Unresectable Hepatic Tumors Using a Triple-Spiral-Shaped Electrode Needle: Initial Experience in 34 Patients显示文摘 | Loukas Thanos Loukia S. Poulou Panayiotis D. Ziakas Alexis D. Kelekis Maria Pomoni Dimitrios A. Kelekis | 2010 | CardioVascular and Interventional Radiology2010，，1： | 1 |
| 9 | Distribu- tion of Persistent Organic Pollutants, Polycyclic Aro- matic Hydro-Carbons and Trace Elements in Soil and Vegetation Following a Large Scale Landfill Fire in Northern Greece显示文摘 | Loukia C Panagiofis G Athanasios K | 2008 | Environ Pollut2008，34，2： | 1 |
| 10 | A Holistic Evaluation Plan for Agent Based Brokerage Systems for Neighbourhood Electricity Usage Optimization显示文摘 | Evangelos Bekiaris Loukia Prentza | 2012 | 材料科学与工程(中英文B版)2012，2，12： | 1 |
| 11 | Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages 显示文摘 | Borja GC Loukia T Kazuhiro I | 2004 | The Journal of Experimental Medicine2004，200，5： | 1 |
| 12 | Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy显示文摘 | Loukia C.Tzarouchi Loukas G.Astrakas SpyridonKonitsiotis SofiaTsouli PersefoniMargariti AnastasiaZikou Maria I.Argyropoulou | 2010 | Journal of Neuroimaging2010，，3： | 1 |
| 13 | Brain involvement in patients with inflammatory bowel disease: a voxel-based morphometry and diffusion tensor imaging study显示文摘 | Anastasia K. Zikou Maria Kosmidou Loukas G. Astrakas Loukia C. Tzarouchi Epameinondas Tsianos Maria I. Argyropoulou | 2014 | European Radiology2014，，10： | 1 |
| 14 | Epige netic regulation of airway inflammation 显示文摘 | Adcock Ian M Tsaprouni Loukia Baser Pankaj | 2007 | Current Opinion in Immunology2007，19，6： | 1 |
| 15 | Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's disease-related mutant ot -synuclein显示文摘 | Lin Xian Loukia Parisiadou Gu Xing-long | 2009 | Neuron2009，64，6： | 1 |
| 16 | Leucine rich repeatkinase regulates the progression of neuro pathology induced by Parkinson's disense related mutant alpha-synuclein 显示文摘 | Lin Xian Loukia Parisiadou Gu Xing-long | 2009 | Neuron2009，64，6： | 1 |
| 17 | Distribution of persistent organic pollutants, polycyclic aromatic hydrocarbons and trace elements in soil and vegetation following a large scale landfill fire in northern Greece显示文摘 | Loukia Chrysikou Panagiotis Gemenetzis Athanasios Kouras Evangelia Manoli Eleni Terzi Constantini Samara | 2007 | Environment International2007，，2： | 1 |
| 18 | Terrible Triad Injuries of the Elbow: Does the Coronoid Always Need to Be Fixed?显示文摘 | Loukia K. Papatheodorou James H. Rubright Kathryn A. Heim Robert W. Weiser Dean G. Sotereanos | 2014 | Clinical Orthopaedics and Related Research?2014，，7： | 1 |
| 19 | Particle concentration and mixing characteristics of moderate-to-dense solid-liquid suspensions 显示文摘 | Martina M Loukia N Kalok C L | 2003 | Industrial and Engineering Chemistry Re- search2003，42，24： | 1 |
| 20 | Detection of Helicobacter pylori:A faster urease test can save resources显示文摘AIM: To investigate whether differences in the rapidity of a positive result for Helicobacter pylori can save res ources, by comparing two commercially available urease kits. METHODS: One hundred and eighty-five adults (130 outpatients, 55 inpatients) undergoing gastroscopy were entered prospectively. Patients were divided into two groups: Group 1 (if they were not on PPIs, antibiotics, H2A, bismuth or sucralfate for up to 14 d prior to the endoscopy) and Group 2 (if they were on, or had been on, any of the above medication in the previous 14 d). At endoscopy two sets of biopsies, taken in random order, were placed in the wells of the Campylobacter-like organism (CLO) test (Kimberly-Clark, Utah, USA) and the Quick test (Biohit Plc, Helsinki, Finland). Five additional gastric biopsies were taken for histology/Giemsa and immunohistochemical study. The two urease test slides were read at 2 min, 30 min, 2 h and 24 h. Sensitivity and specif icity at 24 h were determined. RESULTS: At 24 h, for all patients, there was no difference in sensitivity (100% vs 97.5%), specificity (99.3%), positive (97.5%) and negative predictive values (100% vs 99.3%) between the CLO and Quick tests, respectively. There was a positive result at 30 min in 17/41 (41.5%) CLO tests, and in 28/40 (70%) Quick tests, P = 0.05. Quick test enabled the prescription of eradication therapy before discharge in all 28/40 patients. Only 12 (30%) follow-up appointments were needed. If the CLO test had been used alone, only 17 (41.5%) prescriptions would have been possible prior to discharge and 24 (58%) follow-up appointments would be needed (P = 0.001). Of 2000 gastroscopies performed annually at our unit, a saving of 123 follow-up appointments (total: 8856 Euros or 11 808 USD) would be achieved if we switched to the Quick test. CONCLUSION: Direct comparison of locally available urease test kits is worthwhile, since the appropriate choice results in a significant saving of resources. Local costs and follow-up protocols will determine the magnitude of these savings. | Andriani Koumi Theodoros Filippidis Vassilia Leontara Loukia Makri Marios Zenon Panos | 2011 | World Journal of Gastroenterology2011，17，3： | 1 |
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