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| 1 | The prevalence of isolated otolith dysfunction in a local tertiary hospital显示文摘Objective:Patients with dizziness may present with symptoms of tilting,swaying,rocking,floating or with disequilibrium.This may be suggestive of an isolated otolithic dysfunction yet,there is little emphasis on this emerging clinical entity.To characterize and describe the prevalence of isolated otolith dysfunction in a local tertiary hospital and correlate them with clinical diagnosis.Methodology:Retrospective medical chart review of patients who presented with dizziness to the specialist outpatient Otolaryngology clinic,who required vestibular laboratory investigation.Results:Of the 206 patients,more than half of them(52.4%)fulfilled the criteria for either probable or definite isolated otolith dysfunction.When there are clinical symptoms of otolith dysfunction reported,there is a 1.62 odds of a remarkable laboratory otolith finding.The most common clinical finding was“no clear diagnosis”(65.5%)followed by Vestibular Migraine(13.6%).Conclusion:The prevalence of isolated otolith dysfunction is quite high.Laboratory tests of otolith function should be performed more routinely.This can be done in a sequential way to optimize cost effectiveness in countries with no insurance reimbursement.Prospective cohort studies on isolated otolith dysfunction,will lay the groundwork for achieving diagnostic consensus and formulating rehabilitation plans to aid this group of patients。 | Kenneth Wei De Chua Heng Wai Yuen David Yong Ming Low Savitha Hosangadi Kamath | 2022 | Journal of Otology2022，17，1： | 3 |
| 2 | 罗氏芬治疗下呼吸道感染的多中心前瞻性开放性研究显示文摘在加拿大的14家医院进行前瞻性开放性研究,观察每日一次1g罗氏芬(头孢三嗪)治疗下呼吸道感染的效果。病人用本药至少3天。共观察137例病人,年龄19~95岁,平均68岁。91%病例诊断为不伴菌血症的院外感染性肺炎。82%属中度或重度感染。病人用头孢三嗪平均5天,34例病人同时加用了大环内酯类抗生素或甲硝唑,占25%。在静脉注射头孢三嗪至少3天后,59例(43%)改用口服抗菌药物。92.9%病人的治疗结果顺利;仅7.1%病人治疗失败,包括无效和感染复发。全部观察病例中91%符合评定疗效的研究条件,其中临床治愈占64.6%,好转占28.3%,2例病人复发,占1.8%;6例治疗无效,占5.3%,12例病人死于与治疗研究药物无关的病因,占8.8%,3例出现可能与头孢三嗪有关的不良反应,表现为荨麻疹、腹泻和注射部位静脉炎。加拿大全国性的致病菌,常见的肺炎致病菌体外敏感性监测结果表明,血清中的头孢三嗪浓度,超过90%菌株最低抑菌浓度,从而支持作者采用的头孢三嗪治疗剂量方案,仅肠杆菌属例外。研究结果表明,需要住院的感染性肺炎病人可用头孢三嗪每日一次1g静脉注射作经验性治疗。 | Low DE Mandell LA | 1998 | 上海医药1998，10，3： | 2 |
| 3 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Poutanen SM Low DE Henry B | 2003 | N Engl J Med2003，348，： | 2 |
| 4 | Identification of Severe Acute Respiratory Syndrom in Canda显示文摘 | Poutanen SM Low DE Henry B | 2003 | N Engl J Med2003，10，： | 1 |
| 5 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Poutanen SM Low DE Henry B | | 0，，： | 1 |
| 6 | New Delhi melallo-beta-laclamase-I in Enterobacteriaceae: emerging resistance 显示文摘 | Pillai DR McGeer A Low DE | 2011 | CMAJ2011，183，1： | 1 |
| 7 | Optimization Flow Control,I:Basic Algorithm and Convergence显示文摘 | Low SH Lapsley DE | 1999 | IEEE/ACM Transactions on Networking1999，7，6： | 1 |
| 8 | FOCUS 2: a randomized,dou- ble - blinded, multicentre, Phase IIl trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community- acquired pneumo- nia 显示文摘 | Low DE File TM Jr Eckburg PB | 2011 | J Ant imicrob Chemother2011，66，3： | 1 |
| 9 | The gene encoding the splicing factor SF2/ASF is a proto-oncogene 显示文摘 | Karni R de Stanchina E Lowe SW | 2007 | Nat Struct Mol Bi-ol2007，14，3： | 1 |
| 10 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Poutanen SM Low DE Henry B | 2003 | N Engl J Med2003，348，20： | 1 |
| 11 | Quinolone resistance among pneumocoeci: therapeutic and diagnostic implications 显示文摘 | Low DE | 2004 | Clin Infect Dis2004，38，4： | 1 |
| 12 | Direct esophageal metastasis from a distant primary tumor is a suhmucosal process:a review of six cases显示文摘 | Imchuk EJ Low DE | 2001 | Dis Esophagus2001，14，34： | 1 |
| 13 | Predicting an- timicrobial resistance in invasive pneumoeoccal infec- tions显示文摘 | Vanderkooi OF Low DE Green K | 2005 | Clin Infect Dis2005，40，： | 1 |
| 14 | Identification of Severe Acute Respiratory Syndrome in Canada显示文摘 | Low DE Henry B | 2003 | N Engl J Med2003，348，： | 1 |
| 15 | Progressive and nonresolving pneu- monia显示文摘 | Low DE Mazzulli T Marrie T | 2005 | Curr Opin Pulm Med2005，11，3： | 1 |
| 16 | Drug-resistant pneumococcal pneumo- nia: clinical relevance and approach to management显示文摘 | Fuller JD McGeer A Low DE | 2005 | Eur J Clin Microbiol Infect Dis2005，24，12： | 1 |
| 17 | Identification of severe acute respiratory syndrome in canada显示文摘 | Poutaanen SM Low DE Henry B | 2003 | New Engl J Med2003，348，20： | 1 |
| 18 | Clinical characteristics at initial presentation and impact of dual therapy on the outcome of bacteremic Streptococcus pneumoniae pneumonia in adults 显示文摘 | Weiss K Low DE Cortes L | 2004 | Can Respir J2004，11，8： | 1 |
| 19 | Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling显示文摘 | de Lau W Barker N Low TY | 2011 | Nature2011，476，： | 1 |
| 20 | Antimicrobial susceptibility among organisms from the Asia/Pacific Rim, Europe and Latin and North America collected as part of TEST and the in vitro activity of tigecycline显示文摘 | Reinert RR Low DE Rossi F | 2007 | J Antimicrob Chemother2007，60，5： | 1 |
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