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| 1 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 2 | Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus 显示文摘 | Lu X Whitaker B Sakthivel SK Kamili S Rose LE Lowe L Mohareb E Elassal EM Al-sanouri T Haddadin A Erdman DD | 2014 | J Clin Microbiol2014，52，1： | 1 |
| 3 | Progress in redox flow batteries,remaining challenges and their applications in energy storage显示文摘 | Leung Puiki Li Xiaohong De León Carlos Ponce Berlouis Leonard Low C T J Walsh Frank C | 2012 | RSCAdvances2012，2，10： | 1 |
| 4 | Corneal reshaping influences myopic prescrip- tion stability (CRIMPS) : an analysis of the effect of orthokeratolo- gy on childhood myopic refractive stability 显示文摘 | Downie LE Lowe R | 2013 | Eye Contact Lens2013，39，4： | 1 |
| 5 | Lipid A mutant Salmonellawith suppressed virulence and TNF induction retain tumour-targeting in vivo显示文摘 | Low K B Ittensohn M Le T | 1999 | Nat Biotechnol1999，17，： | 1 |
| 6 | Chin development as a result of differential jaw growth显示文摘 | Marshall SD Low LE Holton NE | 2011 | Am J Orthod Dentofacial Orthop2011，139，4： | 1 |
| 7 | ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation显示文摘 | Valentin Fuster Lars E. Rydén David S. Cannom Harry J. Crijns Anne B. Curtis Kenneth A. Ellenbogen Jonathan L. Halperin Jean-Yves Le Heuzey G. Neal Kay James E. Lowe S. Bertil Olsson Eric N. Prystowsky Juan Luis Tamargo Samuel Wann | 2006 | Journal of the American College of Cardiology2006，，4： | 1 |
| 8 | Papulonodular dew, hal mu- cinosis in lupus ethematosus显示文摘 | Lowe L Rapini RP Golitz LE | 1992 | J Am Aead Dermatol1992，27，2： | 1 |
| 9 | Organic-aciduria, de- creased renal ammonia production, hydrophthalmos, and mental retardation ; a clinical entity 显示文摘 | LOWE CU TERREY M MAC LE | 1952 | AMA Am J Dis Child1952，83，2： | 1 |
| 10 | Organic-aciduria, decreased renal ammonia production, hydrophthalmos, and mental retardation; a clinical entity显示文摘 | Lowe CU Terrey M Mac LE | 1952 | AMA AmJ Dis Child1952，83，2： | 1 |
| 11 | Chin development as a re- sult of differential jaw growth显示文摘 | Marshall SD Low LE Hohon NE | 2011 | Am J Orthod Dentofac Orthop2011，139，4： | 1 |
| 12 | Lipid A mutant Salmonella with suppressed virulence and TNF alpha induction retain tumor-targeting in vivo显示文摘 | Low KB Ittensohn M Le T | 1999 | Nat Biotechnol1999，17，1： | 1 |
| 13 | Recent advances in the molecular characterization of circulating tumor cells 显示文摘 | Lowes LE Allan AL | 2014 | Cancer2014，6，1： | 1 |
| 14 | Lipid A mutant Sal- monella with suppressed virulence and TNFoL induction retain tumor-targeting in vivo 显示文摘 | Low K B Ittensohn M Le T | 1999 | Nature biotechnology1999，17，1： | 1 |
| 15 | Dynamic 320-slice CT larynx for detection and management of idiopathic bilateral vocal cord paralysis显示文摘 | Ruane LE Lau KK Low K | 2014 | Respirol Case Rep2014，2，1： | 1 |
| 16 | Ground Vibration in the Vicinity of a High-speed Moving Harmonic Strip Load显示文摘 | LEFEUVE-MESGOUEZ G LE HOUEDEC D PEP- LOW A T | 2000 | Journal of Sound and Vibration2000，231，9： | 1 |
| 17 | Mandibular 'tripod' advancement of a Class II Division 2 deepbite malocclusion 显示文摘 | Low LE Moore TE Austin KR | 2010 | Am J Orthod Dentofacial Orthop2010，137，2： | 1 |
| 18 | Lipid A Mutant Salmonella with Suppressed Virulence and TNF Alpha Introduction Retain Tumor-targeting in Vivo显示文摘 | Ittensohn M Le T | 1999 | Nat Biotechnol1999，17，1： | 1 |
| 19 | 2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation显示文摘 | Valentin Fuster Lars E. Rydén Davis S. Cannom Harry J. Crijns Anne B. Curtis Kenneth A. Ellenbogen Jonathan L. Halperin G. Neal Kay Jean-Yves Le Huezey James E. Lowe S. Bertil Olsson Eric N. Prystowsky Juan Luis Tamargo L. Samuel Wann | 2011 | Journal of the American College of Cardiology2011，，11： | 1 |
| 20 | Ultra-thin light-weight laser-induced-graphene (LIG) diffractive optics显示文摘The realization of hybrid optics could be one of the best ways to fulfll the technological requirements of compact,light-weight,and multi-functional optical systems for modern industries.Planar diffractive lens(PDL)such as diffractive lenses,photonsieves,and metasurfaces can be patterned on ultra-thin flexible and stretchable substrates and be conformally attached on top of arbitrarily shaped surfaces.In this review,we introduce recent research works addressed to the design and manufacturing of ultra-thin graphene optics,which will open new markets in compact and light-weight optics for next-generation endoscopic brain imaging,space internet,real-time surface proflometry,and multi-functional mobile phones.To provide higher design flexibility,lower process complexity,and chemical-free process with reasonable investment cost,direct laser writing(DLW)of laser-induced-graphene(LIG)is actively being applied to the patterning of PDL.For realizing the best optical performances in DLW,photon-material interactions have been studied in detail with respect to different laser parameters;the resulting optical characteristics have been evaluated in terms of amplitude and phase.A series of exemplary laser-written 1D and 2D PDL structures have been actively demonstrated with different base materials,and then,the cases are being expanded to plasmonic and holographic structures.The combination of these ultra-thin and light-weight PDL with conventional bulk refractive or reflective optical elements could bring together the advantages of each optical element.By integrating these suggestions,we suggest a way to realize the hybrid PDL to be used in the future micro-electronics surface inspection,biomedical,outer space,and extended reality(XR)industries. | Younggeun Lee Mun Ji Low Dongwook Yang Han Ku Nam Truong-Son Dinh Le Seung Eon Lee Hyogeun Han Seunghwan Kim Quang Huy Vu Hongki Yoo Hyosang Yoon Joohyung Lee Suchand Sandeep Keunwoo Lee Seung-Woo Kim Young-Jin Kim | 2023 | Light(Science & Applications)2023，12，7： | 1 |
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