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| 1 | Effective use of FibroTest to generate decision trees in hepatitis C显示文摘AIM:To assess the usefulness of FibroTest to forecast scores by constructing decision trees in patients with chronic hepatitis C.METHODS:We used the C4.5 classification algorithm to construct decision trees with data from 261 patients with chronic hepatitis C without a liver biopsy.The FibroTest attributes of age,gender,bilirubin,apolipoprotein,haptoglobin,α2 macroglobulin,and γ-glutamyl transpeptidase were used as predictors,and the FibroTest score as the target.For testing,a 10-fold cross validation was used.RESULTS:The overall classification error was 14.9%(accuracy 85.1%).FibroTest's cases with true scores of F0 and F4 were classified with very high accuracy(18/20 for F0,9/9 for F0-1 and 92/96 for F4) and the largest confusion centered on F3.The algorithm produced a set of compound rules out of the ten classification trees and was used to classify the 261 patients.The rules for the classification of patients in F0 and F4 were effective in more than 75% of the cases in which they were tested.CONCLUSION:The recognition of clinical subgroups should help to enhance our ability to assess differences in fibrosis scores in clinical studies and improve our understanding of fibrosis progression. | Dana Lau-Corona Luís Alberto Pineda Héctor Hugo Avilés Gabriela Gutiérrez-Reyes Blanca Eugenia Farfan-Labonne Rafael Núez-Nateras Alan Bonder Rosalinda Martínez-García Clara Corona-Lau Marco Antonio Olivera-Martínez Maria Concepción Gutiérrez-Ruiz Guillermo Robles-Díaz David Kershenobich | 2009 | World Journal of Gastroenterology2009，15，21： | 2 |
| 2 | Human multipotent stromal cells from bone marrow and mieroRNA:regulation of differenti- ation and leukemia inhibitory factor expression显示文摘 | Oskowitz AZ Lu J Penfornis P | 2008 | Proc Natl Acad Sci U S A2008，105，18： | 1 |
| 3 | Human multipotent stromal cells from bone marrow and microRNA:regulation of differentiation and leukemia inhibitory factor expression显示文摘 | Oskowitz AZ Lu J Penfornis P | 2008 | Proc Natl Acad Sci USA2008，105，18： | 1 |
| 4 | Human multipotent stro- real cells from bone marrow and microRNA: regulation of differ- entiation and leukemia inhibitory factor expression 显示文摘 | Oskowitz AZ Lu J Penfornis P | 2008 | Proc Natl Acad Sci U S A2008，105，18： | 1 |
| 5 | Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression 显示文摘 | Oskowitz AZ Lu J Penfornis P | 2008 | Proc Natl Acad Sci USA2008，，18： | 1 |
| 6 | Hyperglycemia magnifies bupivacalne - in- duced cell apoptosis triggered bymitochondria dysfunction and endoplas- mic reticulum stress显示文摘 | Li L Ye XP Lu AZ | 2013 | J Neurosci Res2013，91，6： | 1 |
| 7 | Screening c~-glucosidase inhibitor from natural products by capillary elec trophoresis with immobilised enzyme onto polymer monolith modified by gold nanoparticles显示文摘 | Zhang AZ Ye FH Lu JY | 2013 | Food Chemistry2013，141，： | 1 |
| 8 | Serum transaminase elevation in children with rotavirus gastroenteritis: seven years' experience 显示文摘 | Akelma AZ Ktittiko~lu I Ktiksal T | 2013 | Scand J Infect Dis2013，45，5： | 1 |
| 9 | Human multipotent stromalcells from bone marrow and microRNA:regulation of differentiationand leukemia inhibitory factor expression显示文摘 | Oskowitz AZ Lu J Penfornis P | 2008 | PNAS2008，47，18： | 1 |
| 10 | Screeninga-glucosidase inhibi- tor from natural products by capillary electrophoresis with im- mobilised enzyme onto polymer monolith modified by gold nanopartieles显示文摘 | Zhang AZ Ye FG Lu JY | 2013 | Food Chemistry2013，141，： | 1 |
| 11 | Hyperglycemia magnifies bupivacaine-induced cell apoptosis triggered by mitochon- dria dysfunction and endoplasmic reticulum stress 显示文摘 | Li L Ye XP Lu AZ | 2013 | J Neurosci Res2013，91，： | 1 |
| 12 | Gombined treatment for child refractory mycoplasma pneumoniae pneumonia with ciprofloxacin and Glucocorticoid显示文摘 | Lu AZ Wang LB Zhang XB | | 0，，11： | 1 |
| 13 | Endophytic fungi from a pharmaceutieal plant, Camptotheca acuminata : isolation, identification and bioaetivity显示文摘 | Lin X Lu C Huang Y et aZ | 2007 | World J Micmh P iot2007，23，7： | 1 |
| 14 | Combined treatment for child refractory mycoplasma pneumonia with ciprofloxacin and Glucocorticoid显示文摘 | Lu AZ Wang LB Zhang XB | 2011 | Pediatr Pulmonol2011，46，11： | 1 |
| 15 | Alterations in cerebral microstruc tual integrity in normal aging and in Alzheimer's disease; A multi contrast diffusion MRI study显示文摘 | Lu H Jensen JH H u C et aZ | 2006 | Proc Intl Soc Mag Reson Med2006，14，： | 1 |
| 16 | Human muhipotent stromal cells from bone marrow an d microRNA:regulation of differentiation and leukemia inhibitory factor expression 显示文摘 | Oskowitz AZ Lu J Penfornis P | 2008 | Proc Natl Acad Sci U S A2008，105，18： | 1 |
| 17 | Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression 显示文摘 | Oskowttz AZ Lu J Penfornts P etal | 2008 | Proe Natl Acad Sci U S A2008，105，18： | 1 |
| 18 | An artificial transcriptional activating region with unusual properties显示文摘 | Lu Xiangyang Ansari AZ Ptashne M | 1999 | Proc Natl Acad Sci USA1999，97，5： | 1 |
| 19 | Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression显示文摘 | Oskowitz AZ Lu J Penfomis P Ylostalo J McBride J Flemington EK | 2008 | Proc Natl Acad Sci U S A2008，105，18： | 1 |
| 20 | Human muhipotent stromal cells from bone marrow and mieroRNA:regulation of differentiation and leukemia inhibitory factor expression 显示文摘 | Oskowitz AZ Lu J Penfornis P | 2008 | Proc Natl Acad SciU S A2008，105，18： | 1 |
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