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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Morphologie features in esophageal squamous cell carcinoma of young adults in north ehina显示文摘 | Lu JP Xian MS Hayashi KK | 1994 | Cancer1994，74，2： | 1 |
| 3 | Understanding custom- er satisfaction and loyalty: An empirical study of mobile instant messages in China 显示文摘 | Deng Z Lu Y Wei KK | 2010 | International Journal of Information Management2010，30，4： | 1 |
| 4 | The unique HCV genotype distribu- tion and the discovery of a novel subtype 6u among IDUs co-infec- ted with HIV-1 in Yunnan, China 显示文摘 | Xia XS Lu L Tee KK | 2008 | J Med Virol2008，80，7： | 1 |
| 5 | Purification of human musclederived cells using an immunoselective method for potential use in urological regeneration显示文摘 | Lu SH Yang AH Chen KK | 2010 | BJU Int2010，105，11： | 1 |
| 6 | Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src显示文摘 | Lu KK Trcka D Bendeck MP | 2010 | Cardiovasc Pathol2010，，： | 1 |
| 7 | SN-38-cyclodextrin complexation and its influence on the solubility, stability, and in vitro anticancer activity against ovarian cancer显示文摘 | Vangara KK Ali HI Lu D | 2014 | AAPS Pharm Sci Tech2014，15，2： | 1 |
| 8 | Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Sre 显示文摘 | Lu KK Trcka D Bendeck MP | 2011 | Cardiovasc Pathol2011，20，2： | 1 |
| 9 | Collagen stimulates dis- coidin domain receptor I-mediated migration of smooth muscle cells through Src 显示文摘 | Lu KK Trcka D Bendeck MP | 2010 | Cardiovasc Pathol2010，20，： | 1 |
| 10 | The unique HCV genotypedistribution and the discovery of a novel subtype 6u a-mong IDUs co-infected with HIV-1 in Yunnan,China显示文摘 | Xia XS Lu L Tee KK | 2008 | J Med Virol2008，80，7： | 1 |
| 11 | The unique HCV genotype distribu- tion and the discovery of a novel subtype 6u among IDUs co-infec- ted with HIV-1 in Yunnan, China 显示文摘 | Xia X Lu L Tee KK | 2008 | J Med Virol2008，80，7： | 1 |
| 12 | The unique HCV genotype:distribution and the discovery of a novel subtype 6u among IDUs co - infected with HIV - I in Yunnan,China显示文摘 | Xia X Lu L Tec KK | 2008 | J Med Virol2008，80，： | 1 |
| 13 | The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co - infected with H1V- 1 in Yunnan, China显示文摘 | Xia X Lu L Tee KK et a/ | 2008 | J Med Virol2008，80，7： | 1 |
| 14 | Collagen stimulates dis- coidin domain receptor 1-mediated migration of smooth muscle cells through Src 显示文摘 | Lu KK Trcka D Bendeck MP | 2011 | Cardiovasc Pathol2011，20，2： | 1 |
| 15 | Collagen stimulates discoidin domain receptor 1 - mediated migration of smooth muscle cells through Src 显示文摘 | Lu KK Trcka D Bendeck MP | 2011 | Cardiovasc Pathol2011，20，2： | 1 |
| 16 | Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome显示文摘 | Lu CS Horizon AA Hwang KK | 2005 | Arthritis Rheum2005，52，： | 1 |
| 17 | understanding Customer Satisfac- tion and Loyalty : An Empirical Study of Mobile Instant Messages in China 显示文摘 | Deng Z Lu Y Wei KK | 2010 | International Journal of Information Management2010，30，4： | 1 |
| 18 | Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src显示文摘 | Lu KK Treka D Bendeek MP | 2011 | Cardiovasc Pathol2011，20，2： | 1 |
| 19 | Stereoselec- tivity in metabolism of ifosfamide by CYP3A4 and CYP2B6显示文摘 | Lu H Wang JJ Chan KK Philip PA | 2006 | Xenobiotica2006，38，5： | 1 |
| 20 | The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co-infected with HIV-1 in Yunnan,China显示文摘 | Xia XS Lu L Tee KK | 2008 | J Med Virol2008，80，7： | 1 |
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