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| 1 | Portal vein embolization by fine needle ethanol injection :experimental and clinicalstudies显示文摘AIM To improve the technique of intraportal embolization (PVE) therapy, a new embolic method, was devised and the safety, effectiveness and feasibility were evaluated. METHODS PVE with intraportal ethanol injection via a fine needle was performed in 28 normal dogs, 22 SD rats, and 24 cirrhotic SD rats. After PVE, portography, histological and functional alteration of the liver were evaluated in dogs and rats, and the changes in portal hemodynamics as well as hepatic anatomy were observed in rats. In the clinical study, PVE by ethanol injection was performed in 61 patients with hepatocellular carcinoma under the guidance of portoechography with intraportal injection of CO 2. The effect of PVE was evaluated by ultrasonography and laparotomy. RESULTS The effectiveness and toxicity were dependent on the dose of ethanol. In the dogs, 0 25*!mg/*!kg of ethanol caused incomplete embolization with least liver damage, while 1 0*!mg/*!kg induced complete embolization with a high mortality of 57 1% (4/*!7) due to respiratory arrest. The dose of 0 5*!mg/*!kg resulted in complete embolization with slight toxicity to the liver. In the rats, the survival rate was 100% in normal group but 40 9% in cirrhotic models after ethanol injection by dose of 0 05*!mg/*!100*!g . PVE for cirrhotic rats with 0 03*!mg/*!100*!g of ethanol induced satisfactory embolization with significant hypertrophy in nonembolized lobes, and only slight damage to the hepatic parenchyma, and transient alteration in liver function, portal pressure and portal flow. In the clinical study, 12 cases with reverse portal flow were excluded judged by portoechography. Satisfactory embolization was gained in 90 2% (55/*!61) of the remaining patients determined by ultrasonography and surgery. All cases ran an uneventful postembolization course with no aberrant embolization. CONCLUSION PVE with intraportal ethanol injection of appropriate dosage via a fine needle is safe and effective and has several advantages comparing with transcatheter method. Portoechography is a mandatory approach for the prevention of aberrant embolization. | Lu MD Chen JW Xie XY Liang LJ Huang JF | 1999 | World Journal of Gastroenterology1999，5，6： | 15 |
| 2 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 3 | Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes显示文摘 | Pu LJ Lu L Xu XW | 2006 | Cardiovasc Diabetol2006，20，5： | 1 |
| 4 | Serum advancedglycationendproducts and receptors as prognostic biomarkers indiabeticundergoingcoronaryarterystentimplantation显示文摘 | Shen Y Pu LJ Lu L etal | 2012 | CanJCardiol2012，28，6： | 1 |
| 5 | Noninvasive diagnosis of bron- chial artery aneurysm using dual-source computed tomography angiography 显示文摘 | Zhang LJ Yang GF Lu GM | 2008 | Acta Radiol2008，49，3： | 1 |
| 6 | Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes显示文摘 | Pu LJ Lu L Shen WF | 2006 | Cardiovasc Diabetol2006，5，： | 1 |
| 7 | Association of serum levels of glycated albumin,C-reactive protein and tumor necrosis factor-α with the severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus显示文摘 | Lu L Pu LJ Xu XW | 2007 | Clinical Biochemistry2007，40，11： | 1 |
| 8 | Male systemic lupus erythema- tosus: a review of sex disparities in this disease 显示文摘 | Lu LJ Wallace DJ Ishimori ML | 2010 | Lupus2010，19，2： | 1 |
| 9 | Comparison of myocardial bridging by dual-source CT with conventional coronary angiography 显示文摘 | Lu GM Zhang LJ Guo H | 2008 | Circ J2008，72，7： | 1 |
| 10 | The reverse posterior interosseous flap and its composite flap: Experience with 201 flaps显示文摘 | Lu LJ Gong X Lu XM | 2007 | J Plast Reconstr Aesthet Surg2007，60，7： | 1 |
| 11 | Articular geometry of the glenohumeral joint显示文摘 | Flatow EL Bigliani LU | 1992 | Clin Orthop1992，285，： | 1 |
| 12 | Comparison of myocardial bridging by dual-source CT with conventional coronary angiography显示文摘 | Lu GM Zhang LJ Guo H | 2008 | Circ J2008，72，7： | 1 |
| 13 | Activated human hydroxy‐carboxylic acid receptor‐3 signals to MAP kinase cascades via the PLC‐dependent PKC and MMP‐mediated EGFR pathways显示文摘 | Q Zhou G Li XY Deng XB He LJ Chen C Wu Y Shi KP Wu LJ Mei JX Lu NM Zhou | 2012 | British Journal of Pharmacology2012，，6： | 1 |
| 14 | Increased urinary excretion of 2-hydroyestrone but not 16alphahydroxyestrone in premenopausal woman during a soy diet containing isoflavones 显示文摘 | Lu LJ Cree M Josyula S | 2000 | Cancer Res2000，60，5： | 1 |
| 15 | Decreased ovarian hormones during a soya diet: implications for breast canner prevention 显示文摘 | Lu LJ Anderson KE Grady JJ et aJ | 2000 | CsncerRes2000，60，： | 1 |
| 16 | Proteomic characterization of hu-man plasma high density lipoprotein fractionated by gel filtrationchromatography显示文摘 | Gordon SM Deng J Lu LJ | 2010 | J Proteome Res2010，9，10： | 1 |
| 17 | Expression of human insulin- like growth factor-binding protein-3 in transgenic mice显示文摘 | Murphy LJ Molnar P Lu X | 1995 | J Mol Endocfinol1995，15，3： | 1 |
| 18 | Di- hydroartemisinin~ induces apoptosis in HL-60 leukemia cells de- pendent of iron and p38 mitogen-activated protein kinase activa- tion but independent of reactive oxygen species 显示文摘 | Lu JJ Meng LH Cai YJ Chen Q Tong LJ Lin LP | 2008 | Cancer Biol Ther2008，7，7： | 1 |
| 19 | Clinicopathologic features of breast cancer patients with type 2 diabetes mellitus in southwest of China显示文摘 | WANG RJ LU LJ JIN LB | 2014 | Med Oncol2014，31，： | 1 |
| 20 | Digital subtraction CT angiography for detection of intracranial aneurysms:comparison with three-dimensional digital subtraction angiography显示文摘 | Lu L Zhang LJ Poon CS | 2012 | Radiology2012，262，2： | 1 |
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