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| 1 | Antioxidant role of heme oxygenase-1 in prehepatic portal hypertensive rats显示文摘瞄准:在氧化的肝地位和这项活动和表示上学习胆红素的效果他我在老鼠肝损伤的 oxygenase-1 (HO-1 ) 由 prehepatic 门静脉高血压导致了。方法:Wistar 雄的老鼠,称 200-250 g,在随机被划分成二个组:有调整 prehepatic 门静脉结扎(PPVL ) 导致的 prehepatic 门静脉高血压(PH ) 的一个组和另外的组对应于假冒的操作老鼠。门压力,氧化压力参数,抗氧化剂酶, HO-1 活动和表示和肝的正弦曲线血管舒张被测量。结果:在 PPVL 老鼠,氧化应力被在减少的谷胱甘肽(GSH ) 的反应物质(TBARS ) 内容和减少铺平的 thiobarbituric 酸的显著增加证实。当 HO-1 的活动和表示被提高时,肝抗氧化剂酶,超级氧化物歧化酶(草皮) ,过氧化氢酶(猫) 和谷胱甘肽过氧化物酶(GSH-Px ) 的活动也被减少。胆红素(5 mumol/kg 体重) 的管理在实验的结束前的 24 h 完全阻止了所有这些效果。有 Sn-protoporphyrin IX (Sn-PPIX ) 的预告的处理(100 mug/kg 体重, i.p ) ,一个有势力禁止者惊讶,完全废除了氧化压力并且每氧化象类脂化合物的增加一样在肝 GSH 层次挑起了细微减少。而且,一氧化碳,另一他我分解代谢的产品,在在 PPVL 的肝的区域组织的正弦曲线导致了重要增加。有 Sn-PPIX 的 PPVL 老鼠的预告的处理完全阻止了这效果。结论:这些结果在 prehepatic 门 hypertensive 老鼠在表示上建议 HO-1 的一个有益的角色。 | Soledad Gonzales María Julia Pérez Juan C Perazzo María Luján Tomaro | 2006 | World Journal of Gastroenterology2006，12，26： | 6 |
| 2 | Management of primary achalasia: The role of endoscopy显示文摘Achalasia is an oesophageal motor disorder which leads to the functional obstruction of the lower oesophageal sphincter(LES) and is currently incurable. The main objective of all existing therapies is to achieve a reduction in the obstruction of the distal oesophagus in order to improve oesophageal transit, relieve the symptomatology, and prevent long-term complications. The most common treatments used are pneumatic dilation(PD) and laparoscopic Heller myotomy, which involves partial fundoplication with comparable shortterm success rates. The most economic non-surgical therapy is PD, with botulinum toxin injections reserved for patients with a higher surgical risk for whom the former treatment option is unsuitable. A new technology is peroral endoscopic myotomy, postulated as a possible non-invasive alternative to surgical myotomy. Other endoluminal treatments subject to research more recently include injecting ethanolamine into the LES and using a temporary self-expanding metallic stent. At present, there is not enough evidence permitting a routine recommendation of any of these three novel methods. Patients must undergo follow-up after treatment to guarantee that their symptoms are under control and to prevent complications. Most experts are in favour of some form of endoscopic follow-up, however no established guidelines exist in this respect. The prognosis for patients with achalasia is good, although a recurrence after treatment using any method requires new treatment. | Marisol Luján-Sanchis Patricia Suárez-Callol Ana Monzá-Gallego Inmaculada Bort-Pérez Lydia Plana-Campos Luis Ferrer-Barceló Laura Sanchis-Artero María Llinares-Lloret Juan Antonio Tuset-Ruiz Javier Sempere-Garcia-Argüelles Pilar Canelles-Gamir Enrique Medina-Chuliá | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 5 |
| 3 | In denial Stock market underre--action to going'concern audit report disclosures显示文摘 | Tamer R J LuJ Kausar A | 2004 | Journal of Accounting and Economics2004，8，： | 1 |
| 4 | The germicidal and hormetic effects of UV-C light on reducing brown rot disease and yeast microflora of peaches显示文摘 | Stevens C Khan V A LuJ Y | 1998 | Crop Protection1998，17，： | 1 |
| 5 | Parameter identification and back stepping control of uncertain Lti system显示文摘 | WU X Q LuJ A | 2003 | Chaos Solitons & Fractals2003，18，4： | 1 |
| 6 | Face recognition using kernel direct discriminant analysis al-gorithms 显示文摘 | LUJ W PLATANIOTIS K N VENETSANOPOULOS A N | 2003 | IEEE Transactions on Neural Networks2003，14，1： | 1 |
| 7 | Estimating the bounds for the Lorenz family of chaotic systems显示文摘 | LiDM LuJ A Wu XQ | 2005 | Chaos Solitons Fractals2005，23，2： | 1 |
| 8 | Changes in polyamines, proline and ethylene in sunflower calluses treated with NaCl显示文摘 | Irene Alvarez María Luján Tomaro María Patricia Benavides | 2003 | Plant Cell Tissue and Organ Culture2003，，1： | 1 |
| 9 | Chemical anchorage of polypropylene onto glass fibers: Effect on adhesion and mechanical properties of their composites显示文摘 | Mariana Etcheverry María Luján Ferreira Numa Capiati Silvia Barbosa | 2013 | International Journal of Adhesion and Adhesives2013，，： | 1 |
| 10 | Insulin resistance promotes early atherosclerosis via increased proinfl_ammatory proteins and oxidative stress in fructose-fed ApoE-KO mice 显示文摘 | Cannizzo B Luj~n A Estrella N | 2012 | Exp Diabetes Res2012，2012，94： | 1 |
| 11 | Signal-dependent activa?tion of the MEF2 transcription factor by dissociation from his?tone deacetylases显示文摘 | LuJ Mckinsey T A Nicol R L | 2000 | Proc Natl Acad Sci USA2000，，： | 1 |
| 12 | Glutamine synthetase activity and glutamate uptake in hippocampus and frontal cortex in portal hypertensive rats显示文摘AIM: To study glutamine synthetase (GS) activity and glutamate uptake in the hippocampus and frontal cortex (FC) from rats with prehepatic portal vein hypertension. METHODS: Male Wistar rats were divided into shamoperated group and a portal hypertension (PH) group with a regulated stricture of the portal vein. Animals were sacrificed by decapitation 14 d after portal vein stricture. GS activity was determined in the hippocampus and FC. Specific uptake of radiolabeled L-glutamate was studied using synaptosome-enriched fractions that were freshly prepared from both brain areas. RESULTS: We observed that the activity of GS increased in the hippocampus of PH rats, as compared to control animals, and decreased in the FC. A significant decrease in glutamate uptake was found in both brain areas, and was more marked in the hippocampus. The decrease in glutamate uptake might have been caused by a deficient transport function, signif icantly and persistent increase in this excitatory neurotransmitter activity. CONCLUSION: The presence of moderate ammonia blood levels may add to the toxicity of excitotoxic glutamate in the brain, which causes alterations in brain function. Portal vein stricture that causes portal hypertension modif ies the normal function in some brain regions. | Gabriela Beatriz Acosta María Alejandra Fernández Diego Martín Roselló María Luján Tomaro Karina Balestrasse Abraham Lemberg | 2009 | World Journal of Gastroenterology2009，15，23： | 1 |
| 13 | Glutamate and GABA receptor signalling in the developing brain显示文摘 | Luján A Shigemoto R López-Bendito G | 2005 | Neuroscience2005，130，3： | 1 |
| 14 | Metabolism of selenium compounds catalyzed by the mammalian sel?enoprotein thioredoxin reductase显示文摘 | LUJ BERNDT C HOLMGREN A | 2009 | Biochimica et Biophysica Acta: General Subjects2009，1790，11： | 1 |
| 15 | The germicidal and hormetic effects of UV-C light on reducing brown rot disease and yeast micoflora of peaches显示文摘 | STEVENS C KHAN V A LUJ Y | 1998 | Crop Protection1998，17，： | 1 |
| 16 | SK2 and SK3expression differentially affect firing frequency and precision in dopamine neurons显示文摘 | Deignan J Luján R Bond C Riegel A Watanabe M Williams JT | 2012 | Neuroscience2012，217，2012： | 1 |
| 17 | Comparison of Apigenin,Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves,Embryogenic Cultures and Cell Suspension Cultures of Parsley(Petroselinum crispum)显示文摘In recent years,there has been a growing interest in exploring alternative treatments for bone defects.Bone tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone regeneration.In our study,we specifically investigated the extract of Petroselinum crispum,a plant known for its abundance of osteogenic flavonoids such as apigenin,quercetin,and kaempferol.Our objective was to compare the total flavonoid content(TFC)and their accumulation in different sources.We obtained hydrolyzed aqueous extracts from the leaves of parsley plants(grown for 12 weeks in the field),weekly embryogenic cultures,and suspension cell cultures.The TFC,measured in mg quercetin equivalent per gram of dry weight(QE mg/g dw),was found to be 53.81±0.97 for 52 g dw of leaves(1 kg plant fw),31.10±1.52 for 420 g dw of embryogenic cultures,and 11.80±0.76 for 210 g dw of cell suspensions.Notably,only the leaves and embryogenic cultures showed significant accumulation of osteogenic flavonoids,with apigenin levels of 1.8±0.3 and 0.32±0.02 mg/g dw,and kaempferol levels of 1.0±0.18 and 0.2±0.01 mg/g dw,respectively.Our findings indicate that embryogenic cultures have the potential to produce up to 40%more apigenin in 12 weeks compared to 1 kg of parsley plant,thanks to their superior biomass reproductive competence.These results present a promising biotechnological approach for generating extracts enriched with bioactive compounds,which can be further utilized in in vitro osteogenic testing. | Laura Isabel Arias-Rodríguez Martha Alicia Rodríguez-Mendiola Carlos Arias-Castro Federico Antonio Gutiérrez Miceli Diana Reséndez Pérez María Celina Luján Hidalgo Juan JoséVillalobos Maldonado Norma Alejandra Mancilla Margalli | 2023 | Phyton-International Journal of Experimental Botany2023，92，10： | 0 |
| 18 | Penile prosthesis: Patient satisfaction, use and preference for malleable vs inflatable显示文摘AIM: To evaluate and compare long-term patient satisfaction and use after either malleable penile prosthesis(MPP) or inflatable penile prosthesis(IPP) implantation. METHODS: we present a retrospective unicenter study of 108 patients implanted with either 2 or 3-piece American Medical System^(TM)(AMS^(TM)) or Coloplast^(TM) inflatable penile prosthesis(AMS 700CX^(TM), AMS 700CXR^(TM), AMS Ambicor^(TM) or Coloplast TITAN^(TM)) or malleable(AMS Spectra^(TM) or Coloplast Genesis^(TM)) in our Centre between 1993 and 2011. We collected data from the medical record including follow-up, age and type of prosthesis. We used a four-question telephone surveydesigned ad hoc by urologist in our Department, with three multiple choice questions and a grading answer. After verbal consent was obtained, proposed questions concerned global satisfaction regarding to the procedure, quality of sexual intercourses graded from 0 to 10, frequency of sexual intercourse and about undergoing the same procedure again. SPSS^(TM) version 20.0 was used for the descriptive analysis of the data. RESULTS: Sixty seven(64%) patients underwent a MPP and 41(36%) an IPP. The mean age was 52.6 ± 3.6 years in the MPP group and 57.2 ± 2.8 years in the IPP group(P = 0.02). Total respond rate was 55.5%(60/108). Twenty six out of 33 MPP patients(78.9%) and 19 of the 27 IPP subjects(70.3%) were satisfied or very satisfied with the procedure. The quality of sexual intercourse was rated 7.13 ± 0.39 points in the MPP group and 6.16 ± 0.47 points in the IPP group. Frequency of sexual intercourse was 1 or more times per week in 15(46.9%) patients with MPP and in 12(46.1%) of the IPP patients. Twenty-eight(84.9%) patients who received a MPP would undergo the procedure for the same device again as well as 24(88.9%) of the IPP group. There were no statistical differences between groups regarding the four items in the survey.CONCLUSION: Patients show high satisfaction rate and no statistical differences exist regarding to global satisfaction, use of the device and quality of sexual intercourse depending on the type of penile prosthesis. | Ramón Rogel Bertó Jose Daniel López-Acón Saturnino Luján Marco Domingo Guzmán Ordaz Jurado Francisco Delgado Oliva María Angeles Conca Baenas Francisco Boronat Tormo | 2014 | World Journal of Clinical Urology2014，3，2： | 0 |
| 19 | Role of capsule endoscopy in suspected celiac disease: A European multi-centre study显示文摘AIM To analyze the diagnostic yield(DY), therapeutic impact(TI) and safety of capsule endoscopy(CE).METHODS This is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease(CD)(mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy(Group-Ⅰ, n = 19), seropositive CD without atrophy(Group-Ⅱ, n = 39), contraindication to gastroscopy(Group-Ⅲ, n = 6), seronegative CD without atrophy, but with a compatible context(Group-Ⅳ, n = 99). DY, TI and the safety of CE were analysed.RESULTS The overall DY was 54% and the final diagnosis was villous atrophy(n = 65, 39.9%), complicated CD(n = 12, 7.4%) and other enteropathies(n = 11, 6.8%; 8 Crohn's). DY for groups Ⅰ to Ⅳ was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases(36.9%), diffuse in 19(29.2%), jejunal in 11(16.9%), and patchy in 10 cases(15.4%). Factors associated with a greater DY were positive serology(68.3% vs 49.2%, P = 0.034) and older age(P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE resultschanged the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI(92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention(0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated CD.CONCLUSION CE has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD. | Marisol Luján-Sanchis Enrique Pérez-Cuadrado-Robles Javier Garcia-Lledo José-Francisco Juanmartinena Fernandez Luca Elli Victoria-Alejandra Jiménez-García Juan Egea-Valenzuela Julio Valle-Munoz Cristina Carretero-Ribón Ignacio Fernández-Urién-Sainz Antonio López-Higueras Noelia Alonso-Lazaro Mileidis Sanjuan-Acosta Francisco Sanchez-Ceballos Bruno Rosa Santiago González-Vázquez Federica Branchi Lucía Ruano-Díaz César Prieto-de-Frías Vicente Pons-Beltrán Pilar Borque-Barrera Begona González-Suárez Sofía Xavier Federico Argüelles-Arias Juan-Manuel Herrerías-Gutiérrez Enrique Pérez-Cuadrado-Martínez Javier Sempere-García-Argüelles | 2017 | World Journal of Gastroenterology2017，23，4： | 0 |
| 20 | Upper gastrointestinal endoscopic findings in celiac disease at diagnosis:A multicenter international retrospective study显示文摘BACKGROUND Gastroduodenal endoscopy and biopsy following positive specific serology is considered the gold standard to diagnose celiac disease(CeD)in adults.Whether upper endoscopy helps detect comorbid conditions is unknown.AIM To investigate the prevalence of non-celiac endoscopic findings in patients in whom endoscopy was performed to confirm CeD diagnosis.METHODS This is an observational,descriptive,multicenter,retrospective study that reports endoscopic findings obtained in adult patients enrolled in local registries from four tertiary centers.We collected data reported on first endoscopy,indicated for investigation of CeD.Diagnosis of CeD was performed by histology(≥Marsh 2type mucosal damage)and specific serology.Two European and one North American center included biopsy-confirmed CeD following positive serology.A fourth center(South America)included symptomatic patients undergoing endoscopy,irrespective of CeD serology.The latter cohort included a non-CeD control group.RESULTS A total of 1328 patients(80%female;35 years median age)were enrolled,of whom 95.6%had positive specific serology.In 135 patients,endoscopy revealed 163 abnormalities unrelated to CeD(prevalence:10.1%).Erosive reflux esophagitis(6.4%),gastric erosions(2.0%),and suspicion of esophageal metaplasia(1.2%)were the most common findings.Biopsy-confirmed Barrett’s esophagus was infrequent(0.2%).No endoscopic cancer was detected.Older patients(≥51 years of age)had a higher prevalence of endoscopic findings than those≤50(P<0.01).Within the South American cohort,CeD was associated with a lower rate(8.2%)of comorbid endoscopic findings compared with controls(29.1%;P<0.001).In the adjusted multivariate analysis of this cohort,having CeD was associated with a 72%reduction in the risk of any endoscopic abnormality(P<0.0001),and having alarm symptoms was associated with a 37%reduction in the risk of finding at least one endoscopic lesion(P<0.02).CONCLUSION In this large multicenter study,young adults with positive CeD serology had few comorbid endoscopic findings.Although patients over 51 years had a high prevalence of non-CeD gastroduodenal mucosal damage,no malignancy or premalignant lesions were found. | Juan Pablo Stefanolo Fabiana Zingone Carolina Gizzi Ilaria Marsilio María Luján Espinet Edgardo GustavoSmecuol Mark Khaouli María Laura Moreno María I Pinto-Sánchez Sonia Isabel Niveloni Elena F Verdú Carolina Ciacci Julio César Bai | 2022 | World Journal of Gastroenterology2022，28，43： | 0 |
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