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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Inosine and guanosine preserve neuronal and glial cell viability in mouse spinal cord cultures during chemical hypoxia显示文摘 | Litsky ML Hohl CM Lucas JH Jurkowitz MS | | 0，，： | 1 |
| 3 | Inosine and guanosine preserve neuronal and glia cell viability in mouse spinal cord cultures during chemical hypoxia显示文摘 | Litsky ML Hohl CM Lucas JH | 1999 | Brain Res1999，821，2： | 1 |
| 4 | The role of blood flow in determining the sites of atherosclerotic plaques显示文摘 | Warboys CM Amini N De Luca A | | 0，，： | 1 |
| 5 | Diabetes melli- tus is associated with distal embolization,impaired my- ocardial perfusion,and higher mortality in patients with ST-segment elevation myocardial infarction treated with primary angioplasty and glycoprotein II b- IIIa inhibitors显示文摘 | De Luca G Gibson CM Bellandi F | 2009 | Atherosclerosis2009，207，1： | 1 |
| 6 | Mastagia treatment with tamoxifen显示文摘 | Ortiz-Mendoza CM s Lucas Florea MA Domville Ede G | 2003 | Ginecol Obstet Mex2003，71，： | 1 |
| 7 | Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery 显示文摘 | Enrico S Maria CM Luca M | 2009 | The JournalofNeuroscience2009，29，6： | 1 |
| 8 | Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia 显示文摘 | Giannoudis A Davies A Lucas CM | 2008 | Blood2008，112，： | 1 |
| 9 | A population study of imatinib in chronic myeloid leukaemia demonstrates lower efficacy than in clinical trials显示文摘 | Lucas CM Wang L Austin GM | 2008 | Leukemia2008，22，10： | 1 |
| 10 | Early glycoprotein II b- III a inhibitors in primary angioplasty (EGYPT)cooperation: An individual patient data meta-analysis 显示文摘 | de Luca G Gibson CM Bellandi F | 2008 | Heart2008，94，12： | 1 |
| 11 | Acute fatal fat tissue embolism after autologous fat transfer in a patient with lupus profundus 显示文摘 | Gleeson CM Lucas S Langrish CJ | 2011 | Dermatol Surg2011，37，1： | 1 |
| 12 | Gamma interferon testing in blood and cerebrospinal fluid-rapid method for the diagnosis of tuberculous meningitis显示文摘 | Luca MC Petrovici CM Vata A | 2008 | Rev Med Chir Soc Med Nat Iasi2008，112，1： | 1 |
| 13 | Inducible pRb2/p130 expression and growth-suppressive mechanisms:evidence of a pRb2/p130,p27kip1 and cyclin E negative feedback regulatory loop显示文摘 | Howard CM Claudio PP Luca AD | 2000 | Cancer Res2000，60，10： | 1 |
| 14 | Association between advanced Killip class ar presentation and impaired myocardial infarction treated with primary angioplasty and adjunctive glycoprotein IIb-IIIa inhibitors 显示文摘 | De Luca G Gibson CM Huber K | 2009 | Am Heart J2009，158，3： | 1 |
| 15 | Effect of lead ingestion on functions of vitamin D and its metabolites 显示文摘 | Smith CM Luca HF Tanaka Y | 1981 | J Nutr1981，111，8： | 1 |
| 16 | Function analysis of pRb2/p130 interaction with cyelins显示文摘 | Claudio PP De Luca A Howard CM | 1996 | Cancer Res1996，56，9： | 1 |
| 17 | The role of blood flow in determining the sites of atherosclerotic plaques显示文摘 | Warboys CM Amini N de Luca A | 2011 | F1000 Med Rep2011，3，： | 1 |
| 18 | Inosine and guanosine preserve neuronal and glial cell viability in mouse spinal cord cultures during chemical hypoxia显示文摘 | Litsky ML Hohl CM Lucas JH | 1999 | Brain Res1999，821，： | 1 |
| 19 | Diabetes mel- litus is associated with distal embolization, impaired myo- cardial perfusion, and higher mortality in patients with ST- segment elevation myocardial infarction treated with prima- ry angioplasty and glyeoprotein Ⅱ b-Ⅲ a inhibitors 显示文摘 | De Luca G Gibson CM Bellandi F | 2009 | Atherosclerosis2009，207，： | 1 |
| 20 | Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression 显示文摘 | Lucas CM Harris RJ Giannoudis A | 2011 | Blood2011，117，24： | 1 |
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