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73篇 您的检索式:作者名="Lucas MJ"
    题名 作者 年代 出处 被引量
1Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease.Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg 2021Cell Research2021,31,5:2
2Management of intraocular foreign bodies显示文摘Coleman DJ Lucas BC Rondeau MJ 1987Ophthalmology1987,94,11:1
3Time-to-treatment significantly affects the extent of ST-segment resolution and myocardial blush in patients with acute myocardial infarction by primary angioplasty显示文摘de Luca G Van't Hof AW de Boer MJ 2004Eur Heart J2004,25,12:1
4Impaired myocardial perfusion is a major explanation of the poor outcome observed in patients undergoing primary angioplasty for ST-segment-elevation myocardial infarction and signs of heart failure 显示文摘De Luca G van't Holf AW De Boer MJ 2004Circulation2004,109,8:1
5Outcome of Henoch-Schonlein nephropathy in pediatric patients prognostic factors显示文摘LUCAS GARCIA J ALVAREZ BLANCO O SANAHUJA IBANEZ MJ 2008Nefrologia Spain2008,28,6:1
6Immunofluorometric study of Bcl-2 and Bax expression in clinical fresh tumor samples from breast cancer patients显示文摘Martinez-Arribas F Nunez-Villar MJ Lucas AR 0,,:1
7A randomized trial of labor analgesia in women with pregnancy- induced hypertension显示文摘Lucas MJ Sharma S K Mcintier DO 2001Am J Obstet Gynecol2001,185,:1
8Analysis of visuospatial errors inpatients with Alzheimer's disease or Par- kinson's disease显示文摘Finton MJ Lucas JA Graff-Radford NR J Clin Exp Neuropsyehol0,20,2:1
9The course of labor with and without epidural analgesia 显示文摘 Lucas MJ Ramin SM 1998Am J Obstet Gynecol1998,178,3:1
10Doppler systolic-diastolic ratios in pregnancies complicated by syphilis显示文摘Lucas MJ Theriot SK Wendel GD Jr 1991Obstet Gynecol1991,77,2:1
11Management of intra-ocular foreign bodies 显示文摘Coleman DJ Lucas BC Rondeau MJ 1987Ophthalmology1987,94,12:1
12The course of labor with andwith out epiduralanalgesia显示文摘Alexander JM Lucas MJ Ramin SM 0,,03:1
13Thyrotoxicosis com- plicating pregnancy显示文摘Davis LE Lucas MJ Hankins GD 1989Am J Obstet Gynecol1989,160,1:1
14Outcome of henoch-schonlein nephropathy in pediatric patients, prognostic factors显示文摘Lucas GJ Alvarez Blanco O Sanahuja Ibanez MJ 2008Nefrologia Spain2008,28,6:1
15Hemodynamics, plasma volume and prenodal skin lymph responses to varied resuscitation regimens显示文摘Saxe MJ Dombi GW Lucas WF 1996J Trauma1996,41,2:1
16Fat embolism syndrome显示文摘 Lucas GL 1996Orthopedics1996,19,1:1
17Pregnancy outcomes in women with gestational diabetes compared with the general obstetric population显示文摘Casey BM Lucas MJ Mcintire DD 1997Obstet Gynecol1997,90,2:1
18Diabetes complicating pregnancy显示文摘Lucas MJ 2001Obstet Gynecol Clin North Am2001,28,7:1
19A gain-of-function mutation in the hif2a gene in familial erythrocytosis显示文摘Percy MJ Furlow PW Lucas GS 2008N Engl J Med2008,358,2:1
20Fat embolism syndrome显示文摘 Lucas GL 1996Orthopedics1996,19,1:1
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