|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Human origin of Bacteroides fragilis bacteriophages present in the environment 显示文摘 | TARTERA C LUCENA F JOFRE J | 1989 | Applied and Environmental Microbiology1989，55，10： | 1 |
| 3 | Ultrasound guided core needle biopsy of breast masses: How many cores are necessary to diagnose cancer? 显示文摘 | De Lucena C E Dos Santos Junior J L De Lima Resende C A | 2007 | J Clin Ultrasound2007，35，7： | 1 |
| 4 | Potential errors and misuse of statistics in studies on leakage in endodontics显示文摘 | Lucena C Lopez JM Pulgar R | 2013 | Int Endod J2013，46，4： | 1 |
| 5 | 1H NMR structural characterization of a nonmitogenic, vasodilatory, ischemia-protector and neuromodulatory acidic fibroblast growth factor显示文摘 | Lozano RM Pineda - Lucena A Gonzalez C | 2000 | Biochemistry2000，39，： | 1 |
| 6 | Ionic liquid-based single-drop micro extraction/gas chromatographic / mass spectrometric determination of benzene, toluene, ethy| benzene and xylene isomers in waters显示文摘 | HERRADOR E A LUCENA R C'ARDENAS S | 2008 | J Chromat A2008，1201，1： | 1 |
| 7 | Prognosis factors in cryptococcal meningoencephalitis显示文摘 | Darze C Lucena R Gomes I | 1999 | Arq Neuropsiquiatr1999，57，3： | 1 |
| 8 | Aspectizing multi-Agent systems : from architecture to implementation 显示文摘 | Garcia A Kulesza U Lucena C | 2005 | Lecture Notes in Computer Science2005，，3390： | 1 |
| 9 | ATR-FTIR membrane-based sensor for the simultaneous determination of surfactant and oil total indices in industrial degreasing baths显示文摘 | LUCENA R C(A)RDENAS S GALLEGO M | | 0，，3： | 1 |
| 10 | Genetic diversity of Brazilian natural populations of Anthonomus grandis Boheman ( Coleoptera: Cureulionidae) ,the major cotton pest in the New World显示文摘 | MARTINS W F S AYRES C F J LUCENA W A | 2007 | Genet Mol Res2007，6，1： | 1 |
| 11 | 1H NMR structural characterization of a nonmitogenic,vasodilatory,ischemia protector and neuromodulatory acidic fibroblast growth factor显示文摘 | LOZANO R M PINEDA LUCENA A GONZALEZ C | 2000 | Biochemistry2000，39，17： | 1 |
| 12 | A hybrid heuristic for the diameter constrained minimum spanning tree problem显示文摘 | LUCENA A RIBEIRO C C SANTOS A C | | 0，，03： | 1 |
| 13 | Successful ongoing pregnancies after vitrification of oocytes 显示文摘 | Lucena E Bernal DP Lucena C | 2006 | Fertil Steril2006，85，1： | 1 |
| 14 | Mechanisms of drug-induced liver injury显示文摘 | STEPHENS C ANDRADE R J LUCENA MI | 2014 | Curr Opin Allergy Clin Immu- nol2014，14，4： | 1 |
| 15 | Successful ongoing pregnancies after vitrification of oocytes 显示文摘 | Lucena E Bernal DP Lucena C | 2006 | Fertil Stefil2006，85，1： | 1 |
| 16 | Influence of time and thermocycling on marginal sealing of several dentin adhesive systems 显示文摘 | Lucena Martin C Gonzalez Rodriguez MP Ferrer Luque CM | 2001 | Oper Dent2001，26，6： | 1 |
| 17 | Cipurapaludosa extract prevents methyl mercury-inducedneurotoxicity in mice显示文摘 | LUCENA G M FRANCO J L RIBAS C M | 2007 | Basic Clin PharmacolToxicol2007，101，2： | 1 |
| 18 | Ethylene could influence ferric reductase, iron transporter, and H + - ATPase gene expression by affecting FER (or FER-like) gene activity 显示文摘 | Lucena C Waters B M Romera F J | 2006 | Journal of Experimental Botany2006，57，15： | 1 |
| 19 | 1H NMR structural characterization of a nonmitogenic, vasodilatory,ischemia protector and neiromodulatory acidic fibroblast growth factor显示文摘 | Lozano RM Pineda Lucena A Gonzalez C | 2000 | Biochemistry2000，39，： | 1 |
| 20 | Significance of the presence of lymphocytes in the cytological analysis of transbronchial needle aspiration显示文摘 | Lucena CM Agusti C Martinez-Olondris P | 2011 | Arch Bronconeumol2011，47，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员