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| 1 | High-risk corneal allografts: A therapeutic challenge显示文摘Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in 'low-risk' settings. Furthermore, although corneal graft survival in 'lowrisk' recipients is favourable, the prognosis in 'high-risk' recipients for corneal graft is poor. In 'high-risk' grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of 'high-risk' recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in 'high-risk' recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem of corneal blindness in both 'low-risk' and 'high-risk' hosts. | Tian Yu Vijayalakshmi Rajendran May Griffith John V Forrester Lucia Kuffová | 2016 | World Journal of Transplantation2016，6，1： | 7 |
| 2 | Identification and expansion of human colon-cancer-initiating cells显示文摘 | LUCIA R V DARIO G L EMANUELA P | 2007 | Nature2007，445，： | 1 |
| 3 | Aneuploidy Detection in Mixed DNA Samples by Methylation-Sensitive Amplification and Microarray Analysis 显示文摘 | Lucia B Gregory B Pmn V | 2010 | Clin chem2010，56，5： | 1 |
| 4 | Occurrence of trichothecene mycotoxins in Brazilian corn-based food products显示文摘 | THAIS V M LUCIA M V BAPTISTA G G | 2006 | Food Control2006，17，： | 1 |
| 5 | Family cohesion and chidren’sbehavior problems:a longitudinal investigation显示文摘 | LUCIA V C BRESLAU M | 2006 | PsychiatryRes2006，141，2： | 1 |
| 6 | Species association increases biofilm resistance to chemical and mechanical treatments 显示文摘 | Manuel S Lucia C S Maria J V | 2009 | Water Research2009，，43： | 1 |
| 7 | Microwave electrodynamics of electron-doped cuprate superconductors显示文摘 | Kokales J David Fournier P Mercaldo Lucia V | 2000 | Phys Rev Lett2000，85，： | 1 |
| 8 | Inherited thrombophilic risk factors and venous throraboembolism: distinct role in peripheral deep venous thrombosis and pulmonary embolism显示文摘 | Margaglione M Brancaccio V De Lucia D | 2000 | Chest2000，118，5： | 1 |
| 9 | Piezoelectric pol- ymer transducer arrays for flexible tactile sensors 显示文摘 | LUCIA S LUIGI P MAURIZIO V | 2013 | Sensors Journal2013，13，： | 1 |
| 10 | The safe transition from open to thoracoseopic lobectomy: a 5-year experience 显示文摘 | Seder CW Hanna K Lucia V | 2009 | Ann Thorac Surg2009，88，1： | 1 |
| 11 | Preoperative C-Reactive Protein Predicts Respiratory Infection after Coronary Artery Bypass Graft Surgery 显示文摘 | Mezzomo A Bodin Jr OL Lucia V | 2011 | Arquivos Brasileiros de Cardiologia2011，97，5： | 1 |
| 12 | Determination of Paclobutrazol in Mango by LC/MS/MS System显示文摘 | FERRACIN I LUCIA V NASCMENTO S C | 2008 | Toxicol Lett2008，180，1： | 1 |
| 13 | Selenium:From cancer prevention to DNA damage显示文摘 | LUCIA L VIERA V JELA B | | 0，，1： | 1 |
| 14 | Evaluation of the influence of the column axial load on the behavior of monotonically loaded R/C exterior beam-column joints through nu- merical simulations 显示文摘 | Haach V G LUcia Homce De Cresce E1 Debs Ana Khalil E1 Debs M | 2008 | Engineering Structures2008，30，4： | 1 |
| 15 | Multistage expansion planning for ac-tive distribution networks under demand and distributed generation显示文摘 | Lucia C Borges T Ferreira V | 2012 | Int J Electr Power Energy Syst2012，36，1： | 1 |
| 16 | Design pattern recovery through visual language parsing and source code analysis显示文摘 | Lucia A D Deufemia V Gravino C | 2010 | Jour- nal of Systems and Software2010，82，7： | 1 |
| 17 | Determinants of bone mass in systemic lupus eryththematosus显示文摘 | Luigi S Massimiliano V Lucia B | 1999 | Rheumatol1999，26，6： | 1 |
| 18 | Inherited thrombophilic risk factors and venous thromboembolism:distinct role in peripheral deep venous thrombosis and pulmomary embolism显示文摘 | Margaglione M Brancaccio V De Lucia D | 2000 | Chest2000，118，： | 1 |
| 19 | How To Optimize Downhole Motor Guidance System Performance显示文摘 | De Lucia F V | 1992 | Petroleum Engineer International1992，，6： | 1 |
| 20 | Diabetes,glucose control and mean platelet volume:a single-centre cohort study显示文摘 | Monica V Alon S Lucia B | 2014 | Diabetes Research and Clinical Practice2014，104，2： | 1 |
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