|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Effect of unburned carbon content in fly ash on the retention of 12 elements out of coal-combustion flue gas显示文摘The aim of this study was to evaluate whether unburned carbon particles present in fly ash can help in the retention of S,Cl,Br,As,Se,Cu,Ni,Zn,Ga,Ge,Rb,and Pb out of flue gas during the coal combustion at fluidised-bed power station where the coal was combusted along with limestone.The competitive influence of 10%-25% CaO in fly ashes on the distribution of studied elements was studied as well to be clear which factor governs behaviour of studied elements.Except of S(with significant association with CaO) and Rb and Pb(with major affinity to Al2O3) the statistically significant and positive correlation coefficients were calculated for the relations between unburned carbon content and Br(0.959),Cl(0.957),Cu(0.916),Se(0.898),Ni(0.866),As(0.861),Zn(0.742),Ge(0.717),and Ga(0.588) content.The results suggest that the unburned carbon is promising material in terms of flue gas cleaning even if contained in highly calcareous fly ashes. | Lucie Bartonov Bohumír ech Lucie Ruppenthalov Vendula Majvelderov Dagmar Juchelkov Zdeněk Klika | 2012 | Journal of Environmental Sciences2012，24，9： | 3 |
| 3 | Russell body duodenitis with immunoglobulin kappa light chain restriction显示文摘Russell bodies are eosinophilic intracytoplasmic globules which are likely the result of disturbed secretion of immunoglobulins that accumulate within the plasma cell. Russell body collections have been identified within the stomach, known as Russell body gastritis. Similar lesions within the duodenum are referred to as Russell body duodenitis, which is rare. Several Russell body gastritis case reports are associated with Helicobacter pylori. However, the etiology of Russell body duodenitis remains unclear. Here we report the first case of Russell body duodenitis with immunoglobulin light chain restriction in a background of peptic duodenitis. | William R Munday Lucy Harn Kapur Mina Xu Xuchen Zhang | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，1： | 2 |
| 4 | Timing of ventricular septal rupture after acute myocardial infarction and its retation to thrombolytic therapy显示文摘 | Oskoui R Lucy B Voorhees V | 1996 | Am J Cardiol1996，78，： | 1 |
| 5 | Viral genome phylogeny based on Lempel-Ziv complexity and Haus- dorff distance 显示文摘 | YU C LUCY HE R YAU S S-T | 2014 | Journal of theoretical biology2014，348，： | 1 |
| 6 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 7 | Applications of free living plant growth-promoting rhizobacteria显示文摘 | Lucy M Reed E Glick B R | 2004 | Antonie Van Leeuwenhoek2004，86，1： | 1 |
| 8 | Managing mistletoes:the value of local practices for a non - timber forest resource 显示文摘 | Lucy Rist R Uma Shaanker E J Milner - Gulland | 2008 | Forest Ecology and Management2008，255，5： | 1 |
| 9 | Mechanical effects of airway humidification devices in difficult to wean patients*显示文摘 | Christophe Girault Lucie Breton Jean-Christophe Richard Fabienne Tamion Philippe Vandelet Jér?me Aboab Jacques Leroy Guy Bonmarchand | 2003 | Critical Care Medicine2003，，5： | 1 |
| 10 | Healthy Hearts-A community-based primary prevention to reduce coronary heart disease 显示文摘 | Gill R Hugo C W Lucy M et a l | 2008 | BMC Cardio- vascular Disorders2008，26，8： | 1 |
| 11 | Delineation of the domains required for physical and functional interaction of p14ARF with human topoisomerase I 显示文摘 | Olivier A Lucie K Jean-Francois R | 2003 | Oncogene2003，22，： | 1 |
| 12 | Influence of the catalyst type on the growth of carbon nanotubes via methane chemical vapor deposition 显示文摘 | Lucie J Anne D Emmanuelle R | 2006 | J Phys Chem B2006，110，14： | 1 |
| 13 | Efficacy of an intrigue inal progesterone trend an injection a of PGF2α or synchronizing estrus and shortening the interval to pregnancy in post partum beef cows per I pubertal beef heifers and dairy heifers显示文摘 | LUCY M C BILLINGS H J BUTLER W R | 2001 | Animal Sci2001，79，4： | 1 |
| 14 | The antianginal drug trinetazidine shifts cardiac energy metabolism from fatty acidoxidation to glucose oxidation by inhibiting mitochondrial longchain 3-ketoacyl coenzyme A thiolase显示文摘 | Kantor PF Lucie N Kozal R | | 0，，05： | 1 |
| 15 | Influence of the molar mass distribution on the elongational behavior of polymer solutions in capillary breakup显示文摘 | Lucy E R Timothy P S Justin J C | | 0，，1： | 1 |
| 16 | The role of Cd28 and cytotoxic T-lymphocyte antigen-4(CTLA-4) in regulatory T-cell biology显示文摘 | David MS Lucy SK Walke R | 2006 | Immunol Rev2006，21，2： | 1 |
| 17 | Extraction of ribosomal RNA and genornic DNA from soil for studying the diversity of the indigenous bacterial community 显示文摘 | Gabriela F D Alexandre S R Lucy S A C | 1998 | J Microbiol Meth1998，32，： | 1 |
| 18 | Successful pregnancy after thermal balloon endometrial ablation followed by in vitro fertilization and embryo transfer显示文摘 | David K Lucie B Karel R | 2010 | Fertil Steril2010，93，3： | 1 |
| 19 | Development of an aggrega- tion assay to screenFimH antagonists显示文摘 | Daniela A Gina R Lucie H eta! | 2010 | J Microbiol Meth2010，，82： | 1 |
| 20 | Determination of zwitterionic and cationic surfactants by highperformance liquid chromatography with ch nitrogen detection显示文摘 | Christopher R Harrison Charles A Lucy | 2002 | Journal of Chromatography A2002，956，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员