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| 1 | Crosslinking and functionalization of acellular patches via the self-assembly of copper@tea polyphenol nanoparticles显示文摘Decellularization is a promising technique to produce natural scaffolds for tissue engineering applications.However,non-crosslinked natural scaffolds disfavor application in cardiovascular surgery due to poor biomechanics and rapid degradation.Herein,we proposed a green strategy to crosslink and functionalize acellular scaffolds via the self-assembly of copper@tea polyphenol nanoparticles(Cu@TP NPs),and the resultant nanocomposite acellular scaffolds were named as Cu@TP-dBPs.The crosslinking degree,biomechanics,denaturation temperature and resistance to enzymatic degradation of Cu@TP-dBPs were comparable to those of glutaraldehyde crosslinked decellularized bovine pericardias(Glut-dBPs).Furthermore,Cu@TP-dBPs were biocompatible and had abilities to inhibit bacterial growth and promote the formation of capillary-like networks.Subcutaneous implantation models demonstrated that Cu@TP-dBPs were free of calcification and allowed for host cell infiltration at Day 21.Cardiac patch graft models confirmed that Cu@TP-dBP patches showed improved ingrowth of functional blood vessels and remodeling of extracellular matrix at Day 60.These results suggested that Cu@TP-dBPs not only had comparable biomechanics and biostability to Glut-dBPs,but also had several advantages over Glut-dBPs in terms of anticalcification,remodeling and integration capabilities.Particularly,they were functional patches possessing antibacterial and proangiogenic activities.Thesematerial properties and biological functionsmade Cu@TP-dBPs a promising functional acellular patch for cardiovascular applications. | Qin Li Yuan Gao Jiajun Zhang Yangfeng Tang Yangyong Sun Lujia Wu Hao Wu Meifang Shen Xiaohong Liu Lin Han Zhiyun Xu | 2022 | Regenerative Biomaterials2022，9，1： | 1 |
| 2 | Potential recombination between SARS-CoV-2 and MERSCoV:calls for the development of Pan-CoV vaccines显示文摘In a recent study published in Nature,Yan and colleagues demonstrated that NeoCoV,a potential MERS-CoV ancestor in bats,can use bat ACE2 as its entry receptor and that NeoCoV S pseudotyped virus,which contains a T510F mutation in the receptor-binding domain(RBD),enters cells expressing human ACE2(hACE2).1 The findings reveal a potential zoonotic threat that MERS-CoV could,during its evolution,be gaining the ability to use hACE2 as an entry receptor and,thus,could also coinfect ACE2-expressing cells with SARS-CoV-2. | Qiao Wang Lujia Sun Shibo Jiang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 3 | New Strategy for Precise Isolation and Molecular Analysis of Circulating Tumor Cells and Fusion Cells显示文摘A century ago,German pathologist Otto Aichel discovered that tumor cells could fuse with immune cells,forming fusion cells with both immune cell motility and tumorigenic ability of tumor cells,which are more likely to spread and metastasize through the circulatory system.Due to the limitation of currently available approaches,such fusion cells are difficult to be isolated and analyzed thoroughly. | SUN Lujia | 2021 | Bulletin of the Chinese Academy of Sciences2021，35，3： | 0 |
| 4 | Whole Brain Mapping of Primates Enters Micron Era显示文摘The research team of Prof.Guo-Qiang BI and Prof.Pak-Ming Lau from University of Science and Technology of China(USTC)and Shenzhen Institute of Advanced Technology(SIAT)of the Chinese Academy of Sciences,along with domestic and international collaborators,realized three-dimensional mapping of the entire brain of the macaque monkey at micron resolution,based on an updated version of their recently developed high-throughput three-dimensional fluorescence imaging technique VISoR,and an efficient pipeline SMART.This work was published in Nature Biotechnology on July 26^(th). | SUN Lujia | 2021 | Bulletin of the Chinese Academy of Sciences2021，35，3： | 0 |
| 5 | Metabolic Changes Over Life Cycle Show Unexpected Path显示文摘An international research team studying data from thousands of people worldwide has shown that people’s metabolisms peak earlier and decline later in life than previously thought.The study was published in Science on August 13.The researchers analyzed the average calories burned by more than 6,600 people ranging from a one-week-old to a 95-year-old as they went about their daily lives in 29 countries worldwide.They discovered that changes in metabolism involve more than age-related changes in lifestyle or body composition. | SUN Lujia | 2021 | Bulletin of the Chinese Academy of Sciences2021，35，3： | 0 |
| 6 | Exosome Nanoporator:An Innovative Nanofluidic Device to Develop Exosome-based Drug Delivery Vehicles显示文摘The research group of Prof.YANG Hui in Shenzhen Institute of Advanced Technology(SIAT)of the Chinese Academy of Sciences,has recently presented a novel nanofluidic device for high-throughput preparation of exosome-based drug delivery vehicles.Their latest results were published in Small,entitled“A High-Throughput Nanofluidic Device for Exosome Nanoporation to Develop Cargo Delivery Vehicles”,and featured on the back cover. | SUN Lujia | 2021 | Bulletin of the Chinese Academy of Sciences2021，35，3： | 0 |
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