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您的检索式：作者名="Lukas Wallrad"
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| 1 | Ca^(2+)signaling in plant responses to abiotic stresses显示文摘Adverse variations of abiotic environmental cues that deviate from an optimal range impose stresses to plants.Abiotic stresses severely impede plant physiology and development.Consequently,such stresses dramatically reduce crop yield and negatively impact on ecosystem stability and composition.Physical components of abiotic stresses can be,for example,suboptimal temperature and osmotic perturbations,while representative chemical facets of abiotic stresses can be toxic ions or suboptimal nutrient availability.The sheer complexity of abiotic stresses causes a multitude of diverse components and mechanisms for their sensing and signal transduction.Ca^(2+),as a versatile second messenger,plays multifaceted roles in almost all abiotic stress responses in that,for a certain abiotic stress,Ca^(2+)is not only reciprocally connected with its perception,but also multifunctionally ensures subsequent signal transduction.Here,we will focus on salt/osmotic stress and responses to altered nutrient availability as model cases to detail novel insights into the identity of components that link stress perception to Ca^(2+)signal formation as well as on new insights into mechanisms of Ca^(2+)signal implementation.Finally,we will deduce emerging conceptual consequences of these novel insights and outline arising avenues of future research on the role of Ca^(2+)signaling in abiotic stress responses in plants. | Qiuyan Dong Lukas Wallrad Bader O.Almutairi Jörg Kudla | 2022 | Journal of Integrative Plant Biology2022，64，2： | 2 |
| 2 | Ca^(2+)-dependent successive phosphorylation of vacuolar transporter MTP8 by CBL2/3-CIPK3/9/26 and CPK5 is critical for manganese homeostasis in Arabidopsis显示文摘Manganese(Mn)is an essential micronutrient for all living organisms.However,excess Mn supply that can occur in acid or waterlogged soils has toxic effects on plant physiology and development.Although a variety of Mn transporter families have been characterized,we have only a rudimentary understanding of how these transporters are regulated to uphold and adjust Mn homeostasis in plants.Here,we demonstrate that two calcineurin-B-like proteins,CBL2/3,and their interacting kinases,CIPK3/9/26,are key regulators of plant Mn homeostasis.Arabidopsis mutants lacking CBL2 and 3 or their interacting protein kinases CIPK3/9/26 exhibit remarkably high Mn tolerance.Intriguingly,CIPK3/9/26 interact with and phosphorylate the tonoplast-localized Mn and iron(Fe)transporter MTP8 primarily at Ser35,which is conserved among MTP8 proteins from various species.Mn transport complementation assays in yeast combined with multiple physiological assays indicate that CBL-CIPK-mediated phosphorylation of MTP8 negatively regulates its transport activity from the cytoplasm to the vacuole.Moreover,we show that sequential phosphorylation of MTP8,initially at Ser31/32 by the calcium-dependent protein kinase CPK5 and subsequently at Ser35 by CIPK26,provides an activation/deactivation fine-tuning mechanism for differential regulation of Mn transport.Collectively,our findings define a two-tiered calcium-controlled mechanism for dynamic regulation of Mn homeostasis under conditions of fluctuating Mn supply. | Chuanfeng Ju Zhenqian Zhang Jinping Deng Cuicui Miao Zhangqing Wang Lukas Wallrad Laiba Javed Dali Fu Ting Zhang Jörg Kudla Zhizhong Gong Cun Wang | 2022 | Molecular Plant2022，15，3： | 0 |
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