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| 1 | A prospective randomized antiplatelet trial of cilostazol versus clopidogrel in patients with bare metal stent显示文摘Background Cilostazol is a newly developed antiplatelet drug that has been widely applied for clinical use. Its antiplatelet action appears to be mainly related to inhibition of intracellular phosphodiesterase activity. Recently, cilostazol has been used for antiplatelet therapy after coronary bare metal stent implantation for thrombosis and restenosis prevention. This prospective randomized and double blind trial was designed to investigate the safety and efficacy of cilostazol for the prevention of late restenosis and acute or subacute stent thrombosis. Methods One hundred and twenty patients who underwent elective stent were randomly assigned to treatment group with cilostazol 200 mg/d (n = 60), clopidogrel 75 mg/d and aspirin 100 mg/d or to control group with clopidogrel treatment 75 mg/d (n = 60) and aspirin 100 mg/d. Follow-up coronary angiography was performed 6-9 months later. Results Nine months major adverse cardio-cerebral event (MACCE) were lower in treatment groups (P<0.05). The quantitative coronary angiography (QCA) at 6 months follow-up showed that minimum lumen diameter (MLD) was higher in treatment group than that of control group [(2.14±0.52)mm vs (1.82±0.36)mm, P<0.05]. Late lumen loss (LL) [(0.82±0.42)mm vs (1.31±0.58)mm; P<0.01], restenosis rate (RR) (14% vs 32%; P<0.05) and target lesion revascularizaion (TLR) rate (5% vs 17%; P<0.05) were lower in treatment group than in control group. Conclusion Cilostazol therapy is an effective regimen for prevention not only stent thrombosis but also RR and TLR through reducing MLD without the risk of increasing bleeding. | CHEN Yun-dai, LU Yan-ling, JIN Ze-ning, YUAN Fei and Lü Shu-zhengDepartment of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences Beijing Institute of Heart, Lung and Blood Vessel, Beijing 100029, China | 2006 | Chinese Medical Journal2006，，5： | 15 |
| 2 | Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges显示文摘BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver injury and mortality in Western countries and China. However, as to date, there is no direct and effective therapy for this disease. The aim of this review is to analyze the key progress and challenges of main current therapeutic approaches in NAFLD. DATA SOURCE: We carried out a PubMed search of English-language articles relevant to NAFLD therapy. RESULTS: There are two major therapeutic strategies for NAFLD treatment: (1) lifestyle interventions (including weight reduction, dietary modification and physical exercise) and (2) pharmaceutical therapies. Lifestyle interventions, particularly chronic and moderate intensity exercise, are the most effective and recognized clinical therapies for NAFLD. For pharmaceutical therapies, although their effects and mechanisms have been extensively investigated in laboratory studies, they still need further tests and investigations in clinical human trials. CONCLUSION: Future advancement of NAFLD therapy should focus on the mechanistic studies on cell based and animal models and human clinical trials of exercise, as well as the combination of lifestyle intervention and pharmaceutical therapy specifically targeting main signaling pathways related to lipid metabolism, oxidative stress and inflammation. | Jia Xiao Rui Guo Man Lung Fung Emily C Liong George L Tipoe | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 14 |
| 3 | Uniform surface polished method of complex holes in abrasive flow machining显示文摘Abrasive flow machining(AFM) is an effective method that can remove the recasting layer produced by wire electrical discharge machining(WEDM). However, the surface roughness will not be easily uniform when a complex hole is polished by this method. CFD numerical method is aided to design good passageways to find the smooth roughness on the complex hole in AFM. Through the present method, it reveals that the shear forces in the polishing process and the flow properties of the medium in AFM play the roles in controlling the roughness on the entire surface. A power law model was firstly set up by utilizing the effect of shear rates on the medium viscosities, and the coefficients of the power law would be found by solving the algebraic equation from the relations between the shear rates and viscosities. Then the velocities, strain rates and shear forces of the medium acting on the surface would be obtained in the constant pressure by CFD software. Finally, the optimal mold core put into the complex hole could be designed after these simulations. The results show that the shear forces and strain rates change sharply on the entire surface if no mold core is inserted into the complex hole, whereas they hardly make any difference when the core shape is similar to the complex hole. Three experimental types of mold core were used. The results demonstrate that the similar shape of the mold core inserted into the hole could find the uniform roughness on the surface. | Lung TSAI Kuo-Zoo L IANG Chun-Ho LIU | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 2 |
| 4 | Severe community- ac- quired pneumonia caused by macrolide-resistant Mycoplasma pneumoniae in a 6 year-old boy显示文摘 | Lung DC Chan YH Kwong L | 2011 | Hong Kong Med J2011，17，5： | 1 |
| 5 | Tissue distribution of Epstein-Ban:virus genotypes显示文摘 | Chen H L Lung M L Chan K H | 1996 | J Viral1996，70，10： | 1 |
| 6 | Molecular cloning, DNA sequence, and gene expression of the oxalyl - coenzyme A decar- boxylase gene, oxc, from the bacterium Oxalobaeter formigenes 显示文摘 | LUNG H Y BAETZ A L PECK A B | 1994 | JBaeteriol1994，176，8： | 1 |
| 7 | Parental Mental Health and Child Development from Six to Thirty-six Months in a Birth Cohort Study in Taiwan显示文摘 | Lung F W Chiang T L Lin S J | 2009 | J Perinat Med2009，37，4： | 1 |
| 8 | Severe community- acquired pneumonia caused by macrolide-resistant Mycoplasma pneumoniae in a 6-year old boy 显示文摘 | Lung DC Chan YH Kwong L | 2011 | Hong Kong Med J2011，17，5： | 1 |
| 9 | Parental concerns based general developmental screening tool and autism risk:The Taiwan national birth cohort study显示文摘 | Lung F W Shu B C Chiang T L | | 0，，： | 1 |
| 10 | Ranking fuzzy number based on lexicograqhic screening procedure 显示文摘 | Wang M L Wang Hsiaofan Lung Lin Chih | 2005 | International Journal of Information Technology and Decision Making2005，4，4： | 1 |
| 11 | Polyuria Related to Dexmedetomidine 显示文摘 | Pratt A Aboudara M Lung L | 2013 | Anesth Analg2013，117，1： | 1 |
| 12 | Eu- trophication Analysis of Embayments in Prince William Sound Alaska 显示文摘 | Wu Song Lung James L Martin Steve C McCutcheon | 1993 | Journal of Environmental Engineering1993，119，5： | 1 |
| 13 | Preparation,morphology,and thermoresponsive properties of poly(N-isopropylacrylamide)-based copolymer microgels显示文摘 | Chia Lung L Wen Yen C Chia Fen L | 2006 | Polymer Science:Part A:Polymer Chemistry2006，44，4： | 1 |
| 14 | A study of the combina- tion of triamcinolone and 5-fluorouracil in modulating ke- loid fibroblasts in vitro 显示文摘 | Huang L Cai YJ Lung I | 2013 | J Plast Reeonstr Aesthet Surg2013，66，9： | 1 |
| 15 | Heavymetal contents and magnetic properties of playground dust in hong kong显示文摘 | SAI L N LUNG S C KIN C L | 2003 | Environmental Monitoring and Assessment2003，89，： | 1 |
| 16 | Severe community - acquired pneumonia caused by macrolide - resistant Mycoplasma pneumoniae in a 6 - year - old boy显示文摘 | LUNG D C CHAN Y H KWONG L | 2011 | Hong Kong Med J2011，17，5： | 1 |
| 17 | Drosophila males transfer antibacterial proteins from their accessory gland and ejaculatory duct to their mates显示文摘 | Lung O Kuo L Wolfner M F | 2001 | J Insect Physiol2001，47，： | 1 |
| 18 | Properties of beta - propeller phytase expressed in transgenic tobacco显示文摘 | Chan W L Lung S C Lim L B | 2006 | Protein Expression and Purification2006，46，1： | 1 |
| 19 | Optimizing multiple quality character- istics via Taguchi method-based grey analysis 显示文摘 | Lung K P Che C W Shien L W | 2007 | Journal of Material Processing Technology2007，182，13： | 1 |
| 20 | Malignant diseaseappearing late after operation for T1N0 non-small cell lung cancer 显示文摘 | The Lung Cancer Study Group (prepared by Thomas PA Rubinstein L) | 1993 | J Thorac Cardiovasc Surg1993，106，6： | 1 |
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