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| 1 | Pioneer of prostate cancer: past, present and the future of FOXA1显示文摘Prostate cancer is the most commonly diagnosed noncutaneous cancers in North American men.While androgen deprivation has remained as the cornerstone of prostate cancer treatment,resistance ensues leading to lethal disease.Forkhead box A1(FOXA1)encodes a pioneer factor that induces open chromatin conformation to allow the binding of other transcription factors.Through direct interactions with the Androgen Receptor(AR),FOXA1 helps to shape AR signaling that drives the growth and survival of normal prostate and prostate cancer cells.FOXA1 also possesses an AR-independent role of regulating epithelial-to-mesenchymal transition(EMT).In prostate cancer,mutations converge onto the coding sequence and c/s-regulatory elements(CREs)of FOXA1,leading to functional alterations.In addition,FOXA1 activity in prostate cancer can be modulated post-translationally through various mechanisms such as LSD1-mediated protein demethylation.In this review,we describe the latest discoveries related to the function and regulation of FOXA1 in prostate cancer,pointing to their relevance to guide future clinical interventions. | Mona Teng Stanley Zhou Changmeng Cai Mathieu Lupien Housheng Hansen He | 2021 | Protein & Cell2021，12，1： | 12 |
| 2 | Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Quebec Cardiovascular Study显示文摘 | Lamarche B Moorjani S Lupien PJ | 1996 | Circulation1996，94，3： | 1 |
| 3 | Insulin-like growth factor Ⅱ increases the rate of sciatic nerve regeneration in rats显示文摘 | Glazner GW Lupien S Miller JA | | 0，，： | 1 |
| 4 | Apoliprotein A-I and B levels and the risk of ischemic heeart disease during a five year follow up of men in the Quehec cardiovasculer study 显示文摘 | Lamarche B Moorjani S Lupien P | 2000 | Cardio- vasculer Study2000，94，1： | 1 |
| 5 | Principles of Phased Array Ultrasound for Nondestructive Testing 显示文摘 | Lupien V | 2007 | Materials Evaluation2007，65，1： | 1 |
| 6 | Exploiting tumor epigeneties to improve oncolytie virotherapy 显示文摘 | Forbes NE Abdelbary H Lupien M | 2013 | Front Genet2013，4，： | 1 |
| 7 | Effects of stress throughout the lifespan on the brain, behaviour and cognition 显示文摘 | Lupien S1 McEwen BS Gunnar MR | 2009 | Nat Rev Neurosci2009，10，6： | 1 |
| 8 | Allostatic load biomarkers of chronic stress and impact on health and cognition 显示文摘 | Juster RP McEwen BS Lupien SJ | 2010 | Neurosci Biobehav Rev2010，35，1： | 1 |
| 9 | Systemic insulin-like growth factor-1 administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats显示文摘 | Lupien SB Bluhm EJ Ishii DN | 2003 | J Neurosci Res2003，74，4： | 1 |
| 10 | Systemic insulin-like growth factor-Ⅰ administration prevents cognitive impaiment in diabetic rats and brain IGF regulates learning/memory in normal adult rats 显示文摘 | Lupien SB Bluhm EJ Ishii DN | 2003 | J Neurosci Res2003，74，4： | 1 |
| 11 | Coactivator function de- fines the active estrogen receptor alpha cistrome显示文摘 | Lupien M Eeckhoute J Meyer C A | 2009 | Mol Cell Bi- ol2009，29，12： | 1 |
| 12 | Stress, memory, and the hippocampus:can't live with it,can't live without it 显示文摘 | Lepage M | 2001 | Behav Brain Res2001，127，12： | 1 |
| 13 | Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease 显示文摘 | Despres JP Moorjani S Lupien PJ | 1990 | Arteriosclerosis1990，10，4： | 1 |
| 14 | Effects of stress throughout the lifespan on the brain, behaviour and cognition 显示文摘 | Lupien SJ Mcewen BS Gunnar MR | 2009 | Nat Rev Neurosci2009，10，6： | 1 |
| 15 | The sound of stress:Blunted cortisol reactivity to psychosocial stress in tinnitus sufferers显示文摘 | Hebert S Lupien SJ | 2007 | Neurosci Lett2007，411，2： | 1 |
| 16 | Effects of stress throughout the lifespan on the brain,behaviour and cognition显示文摘 | Lupien SJ McEwen BS Gunnar MR | | 0，，06： | 1 |
| 17 | Positive cross- regulatory loop ties GATA-3 to estrogen receptor alpha ex- pression in breast cancer 显示文摘 | Eeckhoute J Keeton EK Lupien M | 2007 | Cancer Res2007，67，13： | 1 |
| 18 | Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats,and brain IGF regulates learning/memory in normal adult rats显示文摘 | Lupien SB Bluhm EJ Ishii DN | 2003 | J Neurosci Res2003，74，4： | 1 |
| 19 | (2005) Hormetic influ- ence of glucocorticoids on human memory 显示文摘 | Lupien SJ Buss C Schramek TE | 2005 | Nonlinearity Biol Toxicol Med2005，3，： | 1 |
| 20 | Systemic insulin-like growth factor-I administration prevents cognitive impairment in diabetic rats,and brain IGF regulates learning/memory in normal adult rats显示文摘 | Lupien SB Bluhm EJ Ishii DN | 2003 | J Neurosci Res2003，74，： | 1 |
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