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| 1 | Extracellular prolyl endoprotease from Aspergillus niger and its use in the debittering of protein hydrolysates显示文摘 | Luppo Eneds Peter Dekker | 2005 | Agricultural and Food Chemistry2005，53，20： | 1 |
| 2 | Extracellular prolyl endoprotease from Aspergillus niger and its use in the debittering of protein hydrolysates显示文摘 | Luppo Edens Peter Dekker Rob Van Der Hoeven | 2005 | Agricultural and Food Chemistry2005，53，20： | 1 |
| 3 | Fail- ure Analysis of A Steam Valve Stem 显示文摘 | IPOHORSKI M LUPPO M I CASTILI G R et 02 | 2003 | Materials Char- acterization2003，，5： | 1 |
| 4 | Creep behavior of an A286 type stainless steel 显示文摘 | Cicco T H D Luppo M I Raffaeli H | 2005 | Materials Characterization2005，55，： | 1 |
| 5 | The glucocorticoid- induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in mice 显示文摘 | LUPPO M NOCENTINI G MAZZON E | 2011 | Br J Pharmacol2011，162，5： | 1 |
| 6 | Creep behavior of an A286 type stainless steel显示文摘 | H. De Cicco M.I. Luppo H. Raffaeli J. Di Gaetano L.M. Gribaudo J. Ovejero-García | 2005 | Materials Characterization2005，，： | 1 |
| 7 | Microstructural development and creep behavior in A286 superalloy显示文摘 | De Cicco H Luppo M I Gribaudo L M | 2004 | Materials Characterization2004，52，2： | 1 |
| 8 | Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study显示文摘AIM:To assesses the safety and efficacy of Aspergillus niger prolyl endoprotease(AN-PEP)to mitigate the im-munogenic effects of gluten in celiac patients.METHODS:Patients with initial diagnosis of celiac disease as confirmed by positive serology with subtotal or total villous atrophy on duodenal biopsies who adhere to a strict gluten-free diet(GFD)resulting in normalised antibodies and mucosal healing classified as Marsh 0 orⅠwere included.In a randomised double-blind placebo-controlled pilot study,patients consumed toast(approximately 7 g/d gluten)with AN-PEP for 2 wk(safety phase).After a 2-wk washout period with adherence of the usual GFD,14 patients were randomised to gluten intake with either AN-PEP or placebo for 2 wk(efficacy phase).Measurements at baseline included complaints,quality-of-life,serum antibodies,immunophenotyping of T-cells and duodenal mucosa immunohistology.Furthermore,serum and quality of life questionnaires were collected during and after the safety,washout and efficacy phase.Duodenal biopsies were collected after the safety phase and after the efficacy phase.A change in histological evaluation according to the modified Marsh classification was the primary endpoint.RESULTS:In total,16 adults were enrolled in the study.No serious adverse events occurred during the trial and no patients withdrew during the trial.The mean score for the gastrointestinal subcategory of the celiac disease quality(CDQ)was relatively high throughout the study,indicating that AN-PEP was well tolerated.In the efficacy phase,the CDQ scores of patients consuming gluten with placebo or gluten with AN-PEP did not significantly deteriorate and moreover no differences between the groups were observed.During the efficacy phase,neither the placebo nor the AN-PEP group developed significant antibody titers.The IgA-EM concentrations remained negative in both groups.Two patients were excluded from entering the efficacy phase as their mucosa showed an increase oftwo Marsh steps after the safety phase,yet with undetectable serum antibodies,while 14 patients were considered histologically stable on gluten with AN-PEP.Also after the efficacy phase,no significant deterioration was observed regarding immunohistological and flow cytometric evaluation in the group consuming placebo compared to the group receiving AN-PEP.Furthermore,IgA-tTG deposit staining increased after 2 wk of gluten compared to baseline in four out of seven patients on placebo.In the seven patients receiving AN-PEP,one patient showed increased and one showed decreased IgA-tTG deposits.CONCLUSION:AN-PEP appears to be well tolerated.However,the primary endpoint was not met due to lack of clinical deterioration upon placebo,impeding an effect of AN-PEP. | Greetje J Tack Jolanda MW van de Water Maaike J Bruins Engelina MC Kooy-Winkelaar Jeroen van Bergen Petra Bonnet Anita CE Vreugdenhil Ilma Korponay-Szabo Luppo Edens B Mary E von Blomberg Marco WJ Schreurs Chris J Mulder Frits Koning | 2013 | World Journal of Gastroenterology2013，19，35： | 1 |
| 9 | Airborne microflora in poultry slaughtering establishments显示文摘 | Luppo Ellerbroek | 1997 | Food Microbiology1997，14，6： | 1 |
| 10 | Preparatory versus main competitions: differences in performances, lactate responses and pre-competition plasma cortisol concentrations in elite male swimmers显示文摘 | BONIFAZI M SARDELLA F LUPPO C | 2000 | Eur J Appl Physiol2000，82，： | 1 |
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