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| 1 | 新型去甲斑蝥素衍生物的设计合成及体外抗肿瘤活性显示文摘目的:设计合成新型去甲斑蝥素衍生物,并研究其体外抗肿瘤活性。方法:以呋喃和马来酸酐为起始原料经多步反应合成去甲斑蝥素衍生物,化合物经1HNMR、ESI-MS和元素分析确证结构;用MTT法,首先对所有化合物进行抗乳腺癌细胞株4T1体外活性筛选,然后对活性较好的化合物7a和7c进一步作抗肺癌细胞株LLC和抗肝癌细胞株SK-HEP-1的活性检测,同时对这2种化合物进行对正常血管内皮细胞ABAE的损伤试验。结果:设计合成了18种新化合物。其中化合物7a和7c对肿瘤细胞株有一定的抑制作用,而对正常细胞的损伤程度较低。结论:化合物7a和7c对乳腺癌细胞株4T1、肺癌细胞株LLC和肝癌细胞株SK-HEP-1有一定的抑制作用,尤其是化合物7c对正常内皮细胞ABAE的损伤比对照药去甲斑蝥素小得多,有进一步研究的价值。 | 董环文 刘超美 李科 Lurong Zhang Joanne Kim | 2008 | 第二军医大学学报2008，29，12： | 9 |
| 2 | WT-PE:Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing显示文摘Large scale genomic aberrations including duplication,deletion,translocation,and other structural changes are the cause of a subtype of hereditary genetic disorders and contribute to onset or progress of cancer.The current prime editor,PE2,consisting of Cas9-nickase and reverse transcriptase enables efficient editing of genomic deletion and insertion,however,at small scale.Here,we designed a novel prime editor by fusing reverse transcriptase(RT)to nuclease wild-type Cas9(WT-PE)to edit large genomic fragment. | Rui Tao Yanhong Wang Yun Hu Yaoge Jiao Lifang Zhou Lurong Jiang Li Li Xingyu He Min Li Yamei Yu Qiang Chen Shaohua Yao | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 3 | 透明质酸酶(PH-20)对乳腺癌细胞MDA435生长的影响显示文摘目的 探讨人精子细胞膜结合型透明质酸酶 (PH 2 0 )基因对乳腺癌细胞MDA4 35在体内外生长的影响。方法 将PH 2 0cDNA转染到人乳腺癌细胞株MDA4 35中 ,形成MDA4 35 PH2 0。将MDA4 35 PH2 0种植在软琼脂培养皿中 ,以转染空载体pcD NA3的MDA4 35细胞为对照 ,观察PH2 0基因对乳腺癌细胞集落形成能力的影响。再将MDA4 35 PH2 0和MDA4 35 pcDNA3分别以同等条件接种到 5周龄裸鼠皮下 ,在不同时间点上比较两组鼠身上肿瘤大小。结果 转PH2 0基因的MDA4 35细胞在软琼脂培养基中集落形成数量明显高于对照组 ,同时MDA4 35 PH2 0在裸鼠身上的肿瘤生长速度也显著高于对照组。结论 PH 2 0使乳腺癌细胞MDA4 35的恶性度增高并促进其在体内的生长能力。 | 高锋 Lurong Zhang Charles B.Underhill | 2002 | 肿瘤2002，22，4： | 3 |
| 4 | 干扰素调节因子-7对肿瘤细胞生长的影响显示文摘 | 高锋 Lurong Zhang Charles B. Underhill | 2002 | 中华微生物学和免疫学杂志2002，22，2： | 3 |
| 5 | An improved Fouier transform profilometry显示文摘 | Su Xianyu Li Jian Gao Lurong | 1988 | Proceedings of SPIE1988，954，： | 2 |
| 6 | Optical Perfect Shuffle Interconnection Using Computer-Generated Blazed Grating Array显示文摘 | Ping Xu Xiang Zhou Xiaochun Zhang Yongkang Guo Lurong Guo Hong Tang Shida Wu Lixing Yang Ying Chen | 1995 | Optical Review1995，，5： | 1 |
| 7 | What Does Evidence Tell Us about Fragmentation and Outsourcing?显示文摘 | Jones R Kierzkowski H Lurong C | 2005 | International Review of Eco-nomics & Finance2005，14，3： | 1 |
| 8 | Improved Fourier transform profilometry for the automatic measurement of 3D object shapes 显示文摘 | Lurong Guo Xianyu Su Jian Li | 1990 | Optics and Lasers in Engineering1990，28，12： | 1 |
| 9 | What Does Evidence Tell Us about Fragmentation and Outsourcing?显示文摘 | Ronald Jones Henryk Kierzkowski Chen Lurong | 2005 | International Review of Economics and Finance2005，，14： | 1 |
| 10 | What Does the Evidence Tell Us about Fragmentation and Outsourcing显示文摘 | Jones W Ronald Kierzkowski Henryk Chen Lurong | 2004 | International Review of Economics and Finance2004，14，3： | 1 |
| 11 | High-throughput fat quantifications of hematoxylin-eosin stained liver histopathological images based on pixel-wise clustering显示文摘Besides diagnosis of fatty liver disease(FLD) using multiple medical imaging techniques in clinic,accurate fat quantification of liver tissue slice, especially the fat droplets measurement, is still a critical indicator in related pathological researches. Stained by hematoxylin-eosin(HE), different tissue components with different colors need to be identified and measured manually in conventional approaches. Automated liver fat quantification of HE stained images remains challenging because forms and distributions of fat are extremely irregular with no clear boundaries, especially in conducting high-throughput analysis which demands quick processing and higher accuracy for the reference of pathologists. To solve this problem, we propose an automated liver fat quantifications pipeline of HE stained images based on pixel-wise clustering, which firstly extracts high-relevant pixel-level features with color mode transformation, then locates boundaries between nuclei, fat and other components by clustering image pixels in an unsupervised mode, and finally identifies indicative fat droplets based on a set of morphological criteria. The pipeline was verified in analysis of multifold fatty liver treatment assays, with experimental results showing high accuracy and adaptability in fat droplets quantification despite data variance. Quantitative indicators provide a reliable evidence for relevant pathological researches or therapy selection, in which number and average area of indicative fat droplets increased sharply in severe and moderate-grade FLD respectively. Those indicators might be utilized as surrogate biomarkers for further researches. | Peng SHI Junru CHEN Jinke LIN Lurong ZHANG | 2017 | Science China(Information Sciences)2017，60，9： | 1 |
| 12 | A simple and label- free sensor for mercury(Ⅱ) detection in aqueous solution by malachite green based on a resonance scattering spectral assay显示文摘 | WU Yuangen ZHAN Sheushan XU Lurong | 2011 | Chemical Communications2011，47，21： | 1 |
| 13 | What Does Evidence Tell Us About Fragmentation andOutsourcing? 显示文摘 | Jones Ronald Kierzkowski Henryk and Chen Lurong | 2005 | International Review of Economics and Finance2005，，14： | 1 |
| 14 | Refractive microlens array with parabolic section profile and no dead area显示文摘 | CHEN Bo GUO Lurong | 1996 | SPIE1996，2866，： | 1 |
| 15 | Time-varying Reliability Analysis of Long-span Continuous Rigid Frame bridge under Cantilever Construction Stage based on the Monitored Strain Data显示文摘In general,the material properties,loads,resistance of the prestressed concrete continuous rigid frame bridge in different construction stages are time-varying.So,it is essential to monitor the internal force state when the bridge is in construction.Among them,how to assess the safety is one of the challenges.As the continuous monitoring over a long-term period can increase the reliability of the assessment,so,based on a large number of monitored strain data collected from the structural health monitoring system(SHMS)during construction,a calculation method of the punctiform time-varying reliability is proposed in this paper to evaluate the stress state of this type bridge in cantilever construction stage by using the basic reliability theory.At the same time,the optimal stress distribution function in the bridge mid-span base plate is determined when the bridge is closed.This method can provide basis and direction for the internal force control of this type bridge in construction process.So,it can reduce the bridge safety and quality accidents in construction stages. | Yinghua Li Kesheng Peng Lurong Cai Junyong He | 2020 | Journal of Architectural Environment & Structural Engineering Research2020，3，1： | 1 |
| 16 | A new design concept of permanent magnet machine for flux weakening operation显示文摘 | Xu Longya Ye Lurong Li Zhen | 1995 | IEEE Transactions on Industry Applications1995，31，2： | 1 |
| 17 | What does Evidence Tell Us about Fragmentation and Outsourcing显示文摘 | Jones Ronald W Henryk Kierzkowski Chen Lurong | | 0，，： | 1 |
| 18 | A new acylated flavonol glycoside from Derris triofoliata 显示文摘 | Xu LuRong Wu Jun Zhang Si | 2006 | Journal of Asian Natural Products Research2006，8，： | 1 |
| 19 | What does the evidence tell us about ragmentation and outsourcing显示文摘 | Jones R.W Kierzkowski H Lurong C | | 0，，03： | 1 |
| 20 | What Does Evidence Tell Us about Fragmentation and Outsourcing? 显示文摘 | Jones R Kierzkowski H Lurong C | 2005 | International Review of Economics and Finance2005，14，3： | 1 |
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