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| 1 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 2 | Laparoscopic resection for rectal cancer:a case-matched study显示文摘 | Andre da Luz Moreira Mor I Geisler DP | 2011 | Surg Endosc2011，25，： | 1 |
| 3 | Malignant peritoneal mesothelioma-diagnostic and therqpeutic difficulties显示文摘 | Cunha P Luz Z Seves I | 2002 | Acta Med Port2002，15，5： | 1 |
| 4 | Cellulose and cellulignin from sugarcane bagasse reinforced polypropylene composites: Effect of acetylation on mechanical and thermal properties 显示文摘 | Luz S M Tio I D Rocha G I M | 2008 | Composites Part A: Applied Science and Manufacturing2008，39，9： | 1 |
| 5 | Laparoscopic resection for rectal cancer: a case-matched study显示文摘 | Andre da Luz Moreira Mor I Geisler DP | 2011 | Surg Endosc2011，25，： | 1 |
| 6 | Laparoscopic resectionfor rectal cancer:a case-matched study显示文摘 | da Luz Moreira A Mor I Geisler DP | 2011 | Surg Endosc2011，25，1： | 1 |
| 7 | Laparoscopic resection for rectal cancer: a case-matched study 显示文摘 | da Luz Moreira A Mor I Geisler DP | 2011 | Surg Endosc2011，25，1： | 1 |
| 8 | Malignant peritoneal mesothelioma diagnostic and therapeutic difficulties显示文摘 | Cunha P Luz Z Seves I | 2002 | Acta Med Port2002，15，： | 1 |
| 9 | Water Stable Zr-Benzene Dicarboxylate Metal-Organic Frameworks as Photocatalysts for Hydrogen Generation显示文摘 | Silva C G Luz I Llabrés i Xamena F X | 2010 | Chem Eur J2010，16，11： | 1 |
| 10 | Laparoscopic resection for rectal cancer: a case-matched study 显示文摘 | da Luz Moreira A Mor I Geisler DP | 2011 | Surg Endosc2011，25，1： | 1 |
| 11 | Integrated ecological risk assessment of pesticides in tropical ecosyslcnis:A case study with carbofuran in Brazil显示文摘 | Chelinho S Lopes I Natal da Luz T | 2012 | Environmental Toxicology and Chemistry2012，31，2： | 1 |
| 12 | Repetitive work, work underload and coronary heart disease risk factors among blue-collar workers: the cordis study显示文摘 | Melamed S Ben-Avi I Luz J eta/ | 1995 | J Psychosom Res1995，39，1： | 1 |
| 13 | Dopamine induces the accumulation of insoluble prion protein and affects autoph- agic flux 显示文摘 | Luz M H M D Peres I T Santos T G | 2015 | Frontiers in Cellular Neuroscience2015，，9： | 1 |
| 14 | Dynamic modeling of the electric transportation network 显示文摘 | Scir A Tuval I Egu luz V M | 2005 | Europhys Lett2005，71，2： | 1 |
| 15 | Selective aerobic oxidation of activated alkanes with MOFs and their use for epoxidation of olefins with oxygen in a tandem reaction显示文摘 | Luz I Le6n A Boronat M | | 0，，02： | 1 |
| 16 | Electrical characteristics in unipolar conjugated polymer devices:the case of modified transport properties in the neighbourhood of the top electrode/polymer interface显示文摘 | KOEHLER M DA LUZ M G E HUMMELGEN I A | 2001 | J Phys D:Appl Phys2001，34，1： | 1 |
| 17 | Effective Method of Mierocapsules Production for Smart Fabrics显示文摘 | Luz S 6 nchez-Silva Paula S (a nchez Juan F Rodr i guez | 2011 | Developments in Heat Transfer2011，，9： | 1 |
| 18 | Effect of time and temperature on bioactive compounds in germinated Brazilian soybean cultivar BRS 258 显示文摘 | I Luz M P Mark A B Jos6 Marcos G M | 2010 | Journal of Food Research International2010，43，： | 1 |
| 19 | Sporulation of Beauveria bassiana on cadavers of Triatoma infestans after infection at different temperature and doses of inoculum 显示文摘 | Luz C Silva I G Cordeiro M T Tigano M S | 1999 | Journal of Invertebrate Pathology1999，73，： | 1 |
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