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| 1 | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency显示文摘Background: Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus.In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake(DMI) and average daily gain(ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake(RFI) and select 20 animals for the high feed efficient(LRFI) and 20 for the low feed efficient(HRFI) groups. Blood samples were collected on d 56 and at slaughter(80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels.Results: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter(P = 0.0049). Gene expression of leptin were greater in LRFI animals(P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression.Conclusion: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pamela Almeida Alexandre Miguel Henrique Santana Francisco JoséNovais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme JoséBento Sterman Ferraz Heidge Fukumasu | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 3 |
| 2 | Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C显示文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature. | Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva | 2012 | World Journal of Gastroenterology2012，18，2： | 3 |
| 3 | Toxoplasmosis among pregnant women:High seroprevalence and risk factors in Kinshasa,Democratic Republic of Congo显示文摘Objective:To determine the seroprevalence of toxoplasmosis in pregnant women,as well as the proportion of acutely infected and risk factors in the Democratic Republic of Congo.Methods:Thirty maternities in Kinshasa were randomly selected and women attending antenatal consultation were invited to participate.They were interviewed with a structured questionnaire about known risk factors(age,meat consumption,contact with soil,and presence of cat)and a venous blood sample was taken.Sera were analysed for total immunoglobulins(Ig)by VIDAS Toxo Competition using Enzyme Linked Fluorescent Assay.IgM was determined by VIDIA Toxo IgM and IgG avidity by VIDAS Toxo IgG avidity.Results:A total of 781 women were included.Median age was 28 years old(IQR:8.S).And 627women(80.3%;95%CI:77.5-83.1)were found to be positive to total Ig and 17 out of 387(4.4%;95%CI:2.3-6.4)were positive to IgM.IgC avidity was low for 2(11.8%)women,intermediate for 2(11.8%)and high for 13 women(76.4%).There was no statistically significant association between Toxoplasma gondii infection and any risk factors assessed.Conclusion:In Kinshasa,toxoplasmosis endemicity is highly prevalent.One woman out of twenty five had a recent toxoplasmosis infection and 20%were not protected against primoinfection,indicating a need for measures to prevent and control toxoplasmosis during pregnancy. | Doudou Yobi Renaud Piarroux Coralie L'Ollivier Jacqueline Franck Hypolite Situakibanza Hypolite Muhindo Patrick Mitashi Raquel Andreia Inocencio da Luz Marc Van Sprundel Marleen Boelaert Jean-Pierre Van Geertruyden Pascal Lutumba | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 2 |
| 4 | A survey of indigenous microbial hydrocarbon degradation genes in soils from Antarctica and Brazil显示文摘 | Luz A P Pellizari V H Whyte L G | 2004 | Can J Microbiol2004，50，： | 1 |
| 5 | Multidisciplinary design optimization of an automotive magnetorheological brake design 显示文摘 | Park E Luz L Suleman A | 2008 | Computers gy- Structures2008，86，35： | 1 |
| 6 | A performance evaluation of an automotive magnetorheological brake design with a sliding mode controller显示文摘 | Park E J Stoikov D Luz L F D | | 0，，07： | 1 |
| 7 | Ligand adsorption on an activated carbon for the removal of chromate ions from aqueous solutions显示文摘 | García-Martín J López-Garzón R Luz Godino-Salido M | 2005 | Langmuir2005，21，： | 1 |
| 8 | Pathologic complete response after neoadjuvant treatment for rectal cancer decreases distant recurrence and could eradicate local recurrence 显示文摘 | de Campos-Lobato LF Stocchi L da Luz Moreira A | 2011 | Ann Surg Oncol2011，18，： | 1 |
| 9 | A perform- ance evaluation of an automotive magnetorheological brake design with a sliding mode controller 显示文摘 | PARK E J STOIKOV D DA LUZ L F | 2006 | Mechatronics2006，16，40： | 1 |
| 10 | A performance evaluation of an automotive magnetorheological brake design with a sliding mode controller显示文摘 | Park E J Stoikov D da Luz L F | 2006 | Mechatronics2006，16，7： | 1 |
| 11 | Pathologic complete response after neoadjuvant treatment for rectal cancer decreases distant recurrence and could eradicate local recurrence显示文摘 | de Campos-Lobato LF Stocchi L da Luz Moreira A | 2011 | Ann Surg Oncol2011，18，6： | 1 |
| 12 | TEG(R) and ROTEM(R) in trauma: similar test but different results?显示文摘 | Sankaranlmtty A Nascimanto B Teodoro da Luz L | 2012 | World J Emerg Surg2012，71，： | 1 |
| 13 | 显示文摘 | Borreguero A M Luz Sdnchez M Valverde J L | 2011 | Ap- plied Energy2011，，： | 1 |
| 14 | Phthalate exposure associated with self-reported diabetes among Mexican women显示文摘 | Katherine Svensson Raúl U. Hernández-Ramírez Ana Burguete-García Mariano E. Cebrián Antonia M. Calafat Larry L. Needham Luz Claudio Lizbeth López-Carrillo | 2011 | Environmental Research2011，，6： | 1 |
| 15 | Multiresidue Analysis of Cotton Defoliant,Herbicide,and Insecticide Residues in Water by Solid-Phase Extraction and GCNPD,GC-MS,and HPLC-Diode Array Detection显示文摘 | Thomas L P Luz M Sally B | 2000 | Journal of Agricultural and Food Chemistry2000，48，： | 1 |
| 16 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 17 | A perform ance evaluation of an automotive magnetorheologieal brake design with a sliding mode controller 显示文摘 | Park E J Stoikov D da Luz L F etal | 2006 | Mechatronics2006，16，7： | 1 |
| 18 | Creep behavior modeling of silica fume containing A1203-MgO refractory castables显示文摘 | Tomba Martinez A G Luz A P Braulio M A L | 2012 | Ceramics International2012，38，： | 1 |
| 19 | Struc-tural characterization of coagulant Moringa oera Lectin and its effect on hemostatic param- eters显示文摘 | Luz L A Silva M C Ferreira R S | 2013 | Int J Biol Macromol2013，58，： | 1 |
| 20 | Molecular mechanisms of fluoride toxicity 显示文摘 | BARBIERA O MENDOZAB L A LUZ MARIA DEL RAZOA | 2010 | Chem Biol Interact2010，，188： | 1 |
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