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| 1 | Strategies to improve outcome of patients with hepatocellular carcinoma receiving a liver transplantation显示文摘Liver transplantation is the only therapeutic option which allows to treat both, the hepatocellular carcinoma and the underlying liver disease. Indeed, liver transplantation is considered the standard of care for a subset of patients with cirrhosis and hepatocellular carcinoma.However, tumour recurrence rates are as high as 20%, and once the recurrence is established the therapeutic options are scarce and with little impact on prognosis. Strategies to minimize tumour recurrence and thus to improve outcome may be classified into 3 groups:(1) An adequate selection of candidates for liver transplantation by using the Milan criteria;(2) An optimized management within waiting list including prioritization of patients at high risk of tumour progression, and the implementation of bridging therapies, particularly when the expected length within the waiting list is longer than 6 mo; and(3) Tailored immunosuppression comprising reduced exposure to calcineurin inhibitors, particularly early after liver transplantation, and the addition of mammalian target of rapamycin inhibitors. In the present manuscript the available scientific evidence supporting these strategies is comprehensively reviewed, and future directions are provided for novel research approaches, which may contribute to the final target: to cure more patients with hepatocellular carcinoma and with an improved long term outcome. | Marta Guerrero-Misas Manuel Rodríguez-Perálvarez Manuel De la Mata | 2015 | World Journal of Hepatology2015，7，4： | 8 |
| 2 | Pulmonary vein stenosis:Etiology,diagnosis and management显示文摘Pulmonary vein stenosis(PVS) is rare condition characterized by a challenging diagnosis and unfavorable prognosis at advance stages. At present, injury from radiofrequency ablation for atrial fibrillation has become the main cause of the disease. PVS is characterized by a progressive lumen size reduction of one or more pulmonary veins that, when hemodynamically significant, may raise lobar capillary pressure leading to signs and symptoms such as shortness of breath, cough, and hemoptysis. Image techniques(transesophageal echocardiography, computed tomography, magnetic resonance and perfusion imaging) are essential to reach a final diagnosis and decide an appropriate therapy. In this regard, series from referral centers have shown that surgical and transcatheter interventions may improve prognosis. The purpose of this article is to review the etiology, assessment and management of PVS. | Pablo Pazos-López Cristina García-Rodríguez Alba Guitián-González Emilio Paredes-Galán María ángel De La Guarda álvarez-Moure Marta Rodríguez-álvarez José Antonio Baz-Alonso Elvis Teijeira-Fernández Francisco Eugenio Calvo-Iglesias Andrés íniguez-Romo | 2016 | World Journal of Cardiology2016，8，1： | 6 |
| 3 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 5 |
| 4 | Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey显示文摘 | Juan J. Vila Manuel Pérez-Miranda Enrique Vazquez-Sequeiros Monder Abu-Suboh Abadia Antonio Pérez-Millán Ferrán González-Huix Joan Gornals Julio Iglesias-Garcia Carlos De la Serna José R. Aparicio José C. Subtil Alberto álvarez Felipe de la Morena Jesús G | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 5 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 6 | The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of β-carotene into ast-axanthin and other xanthophylls显示文摘 | lvarez V Rodríguez-Sáiz M De La Fuente JL | 2006 | Fungal Genetics and Biology2006，43，4： | 1 |
| 7 | Prediclors of out- comes of percutebroplasty for osteoprotic vertebral fractures 显示文摘 | Lvarez LA Perez-Higueras A Granizo JJ | 2012 | Spine2012，15，14： | 1 |
| 8 | Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey显示文摘 | Juan J. Vila Manuel Pérez-Miranda Enrique Vazquez-Sequeiros Monder Abu-Suboh Abadia Antonio Pérez-Millán Ferrán González-Huix Joan Gornals Julio Iglesias-Garcia Carlos De la Serna José R. Aparicio José C. Subtil Alberto álvarez Felipe de la Morena Jesús G | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 9 | Percutaneous vertebroplasty functional improvement in patients with osteoporotic compression fractures显示文摘 | Lvarez LA Alcaraz M Perez-Higueras A | 2006 | Spine2006，31，： | 1 |
| 10 | Predictors of outcomes of percutaneous vertebroplasty for osteoporotic vertebral fractures显示文摘 | Lvarez LA Perez-Higueras A Granizo J J | 2005 | Spine2005，30，： | 1 |
| 11 | The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of fl-carotene into astaxanthin and other xanthophylls显示文摘 | LVAREZ V RODR~GUEZ-S ~IZ M de la FUENTE J L | 2006 | Fungal Genetics and Biology2006，43，4： | 1 |
| 12 | Reduced Exposure to Calcineurin Inhibitors Early After Liver Transplantation Prevents Recurrence of Hepatocellular Carcinoma显示文摘 | Manuel Rodríguez-Perálvarez Emmanuel Tsochatzis María Carmen Naveas Giulia Pieri Carmen García-Caparrós James O’Beirne Antonio Poyato-González Gustavo Ferrín-Sánchez Jose Luis Montero-álvarez David Patch Douglas Thorburn Javier Brice?o Manuel De la Mata A | 2013 | Journal of Hepatology2013，，： | 1 |
| 13 | KIR Gene Mismatching and KIR/C Ligands in Liver Transplantation: Consequences for Short-Term Liver Allograft Injury显示文摘 | Isabel Legaz María R. López-álvarez José A. Campillo María R. Moya-Quiles José M. Bolarín Jesus de la Pe?a Gema Salgado Lourdes Gimeno Ana M. García-Alonso Manuel Muro Manuel Miras Clara Alonso María R. álvarez-López Alfredo Minguela | 2013 | Transplantation Journal2013，，8： | 1 |
| 14 | Feature selection by multi-objective optimisation: Application to network anomaly detection by hierarchical self-organising maps显示文摘 | Emiro de la Hoz Eduardo de la Hoz Andrés Ortiz Julio Ortega Antonio Martínez-álvarez | 2014 | Knowledge-Based Systems2014，，： | 1 |
| 15 | Predictors of outcomes of porcutaneous vertaebroplasty for osteoporofic vertebral fractures显示文摘 | Lvarez LA Perez-Higueras A Granizo JJ | 2005 | Spine2005，30，： | 1 |
| 16 | Accumulation and distribution of heavy metals in Scirpus americanus and Typha latifolia from an artificial lagoon in San Luis Potosí,México显示文摘 | Carranza-álvarez C Alonso-Castro A J Alfaro-De La Torte M C | 2008 | Water Air and Soil Pollution2008，188，： | 1 |
| 17 | GOECP/SEOR radiotherapy guidelines for small-cell lung cancer显示文摘Small cell lung cancer(SCLC)accounts for approximately 20%of all lung cancers.The main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non-metastatic SCLC and in those with metastatic SCLC who respond to Ch.Prophylactic cranial irradiation reduces the risk of brain metastases and improves OS in both metastatic and non-metastatic patients.The 5-year OS rate in patients with limited-stage disease(non-metastatic)is slightly higher than 30%,but less than 5%in patients with extensive-stage disease(metastatic).The present clinical guidelines were developed by Spanish radiation oncologists on behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Society of Radiation Oncology to provide a current review of the diagnosis,planning,and treatment of SCLC.These guidelines emphasise treatment fields,radiation techniques,fractionation,concomitant treatment,and the optimal timing of Ch and radiotherapy.Finally,we discuss the main indications for reirradiation in local recurrence. | Felipe Couñago Carolina de la Pinta Susana Gonzalo Castalia Fernández Piedad Almendros Patricia Calvo Begoña Taboada Antonio Gómez-Caamaño JoséLuis López Guerra Marisa Chust JoséAntonio GonzálezFerreira AnaÁlvarez González Francesc Casas | 2021 | World Journal of Clinical Oncology2021，12，3： | 1 |
| 18 | Reduced risk of colorectal cancer among long-term users of aspirin and nonsteroidal anti-inflammatory drugs 显示文摘 | Garcia-Rodriguez LA Huerta A Lvarez C | 2001 | Epidemiology2001，12，1： | 1 |
| 19 | Discrete techniques applied to low-energy mobile human activity recoTfition A new approach显示文摘 | lvarez de la Concepci6n M A Soria Morillo L M Gonzalez A | 2014 | Expert Systems with Applications2014，，14： | 1 |
| 20 | Sustained attention as a potential endophenotype for bipolar disorder显示文摘 | I.Ancín J. L.Santos C.Teijeira E. M.Sánchez‐Morla M. J.Bescós I.Argudo S.Torrijos B.Vázquez‐álvarez I.De La Vega J. J.López‐Ibor A.Barabash J. A.Cabranes‐Díaz | 2010 | Acta Psychiatrica Scandinavica2010，，3： | 1 |
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