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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 3 | Framingham risk score is related to carotid artery intima - media thickness in both white and black young adults: the Bogalusa Heart Study 显示文摘 | LYN K L URBNA EM TANG R | 2003 | Atheroselerosis2003，170，： | 1 |
| 4 | Identification of dehydration-responsive cysteine proteases during post-harvest senescence of broccoli florets显示文摘 | SIMON A C BEN K S LYN M | 2003 | Exp Bot2003，53，384： | 1 |
| 5 | Thevascular endothelial growth factor (VEGF)-E enco-ded by orf virus regulates keratinocyte proliferationand migration and promotes epidermal regeneration显示文摘 | Lyn M Wise Marie K Inder Nicola C Real | 2012 | Cellular microbiol2012，14，9： | 1 |
| 6 | The Septin9 (MSF)gene 23 amplified and overexpressed in mouse mammarygland adenocarcinomas and human breast cancer cell Lines显示文摘 | Montagna C Lyn M S Hunter K | 2003 | Cancer Res2003，63，9： | 1 |
| 7 | Directimaging of the disruption of hepatitis C virus replicationcomplexes by inhibitors of lipid metabolism 显示文摘 | Lyn R K Kennedy D C Sagan S M | 2009 | Virology2009，394，1： | 1 |
| 8 | A hidden Markov chain model for the term structure of bond credit risk spreads显示文摘 | Lyn C T David E A Nigel M K | 2001 | International Review of Financial Analysis2001，，： | 1 |
| 9 | Activity-basedprotein profiling identifies a host enzyme,carboxylesterase 1,which is differentially active duringhepatitis C virus replication 显示文摘 | Blais D R Lyn R K Joyce M A | 2010 | J Biol Chem2010，285，25： | 1 |
| 10 | Bidirectionallipid droplet velocities are controlled by differentialbinding strengths of HCV core DII protein 显示文摘 | Lyn R K Hope G Sherratt A R | 2013 | PLOSONE2013，8，78： | 1 |
| 11 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR Morbidity and Mortality Weekly Report2010，，30： | 1 |
| 12 | Evaluation of low molecular weight fractions and crude enzyme preparation from a Trichoderma cellulase complex as a treatment for fibrous feeds显示文摘 | Llewe|lyn D A Marston T T Teutemacher K L | 2010 | Animal Feed Science and Technology2010，160，： | 1 |
| 13 | Adherence to HAART among HIV -infected- persons in rural louisiana显示文摘 | Hamish M Lyn K | 2004 | AIDS Patient Care and STDs2004，18，： | 1 |
| 14 | A challenge to the anecdotal stereotype of the Asian student显示文摘 | David K Lyn G | 1991 | Studies in Higher Education1991，16，2： | 1 |
| 15 | Cultural specificity of approaches to study显示文摘 | David K Lyn G | 1990 | Br J Educ Psychol1990，60，： | 1 |
| 16 | Effect of UV system modifications on disinfection performance 显示文摘 | Chiu K Lyn D Savoye P | 1999 | Journal of envi- ronmental engineering1999，125，5： | 1 |
| 17 | New Ways of Looking at Old Issues: Inequality and Growth 显示文摘 | DEININGER K LYN SQUIRE | 1998 | Journal of Development Economics1998，57，2： | 1 |
| 18 | Numerical modeling of flow and disinfection in UV disinfection channels显示文摘 | Lyn D Chiu K Blatchley E | 1999 | Journal of environmental engineering1999，125，1： | 1 |
| 19 | Immunosuppression in sepsis 显示文摘 | Lyn -Kew K Standiford TJ | 2008 | Curt Pharm Des2008，14，19： | 1 |
| 20 | Flexible Transgastric Peritoneoscopy and Liver Biopsy: a Feasibility Study in Human Beings显示文摘 | Steele K Sehweitzer M A Lyn Sue J | 2008 | Gastrointest Endose2008，68，1： | 1 |
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