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| 1 | Utility of faecal calprotectin analysis in adult inflammatory bowel disease显示文摘The inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are chronic relapsing, remitting disorders. Diagnosis, along with assessment of disease activity and prognosis present challenges to managing clinicians. Faecal biomarkers, such as faecal calprotectin, are a non-invasive method which can be used to aid these decisions. Calprotectin is a calcium and zinc binding protein found in the cytosol of human neutrophils and macrophages. It is released extracellularly in times of cell stress or damage and can be detected within faeces and thus can be used as a sensitive marker of intestinal inflammation. Faecal calprotectin has been shown to be useful in the diagnosis of IBD, correlates with mucosal disease activity and can help to predict response to treatment or relapse. With growing evidence supporting its use, over the last decade this faecal biomarker has significantly changed the way IBD is managed. | Lyn A Smith Daniel R Gaya | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 2 | Catastrophic gastrointestinal complication of systemic immunosuppression显示文摘We present a case of acute upper gastrointestinal haemorrhage in a patient with systemic vasculitis immunosuppressed on cyclophosphamide and prednisolone.The patient presented with a diffuse haemorrhagic oesophagitis and a non-specific duodenitis.Biopsies taken from the oesophagus and duodenum demonstrated infection with herpes simplex virus(HSV)and cytomegalovirus(CMV)respectively.Viral infection of the upper gastrointestinal tract is a recognised complication of immunosuppression and HSV is one of the most common pathogens.CMV on the other hand most commonly causes a colitis or less commonly oesophagitis.CMV enteritis is rare as is the synchronous infection with two viral agents in an immunocompromised patient having being described in a few case series only.Viral infection of the gastrointestinal tract in immunocompromised patients should be treated with systemic anti-viral medication and consideration to withdrawal of the immunosuppressive therapy if possible and appropriate.The authors highlight the need for a high suspicion of viral infection in immunosuppressed patients presenting with upper gastrointestinal bleeding. | Lyn Alexandra Smith Mitali Gangopadhyay Daniel R Gaya | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | Framingham risk score is related to carotid artery intima - media thickness in both white and black young adults: the Bogalusa Heart Study 显示文摘 | LYN K L URBNA EM TANG R | 2003 | Atheroselerosis2003，170，： | 1 |
| 4 | The 894T allele of endothelial nitric oxide synthase gene is related to left ventricular mass in African Americans with high-normal blood pressure 显示文摘 | Lapu-Bula R Quarshie A Lyn D | 2005 | J Natl Med Assoc2005，97，2： | 1 |
| 5 | Comparison of ELISA and LC-MS analyses for yessotoxins in blue mussels (Mytilus edulis) 显示文摘 | INGUNN A SAMDAL JOHN A B AASEN LYN R BRIGGS | 2005 | Toxicon2005，46，： | 1 |
| 6 | Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function,and blood pressure in African Americans显示文摘 | Li R Lyn D Lapu-Bula R | 2004 | Am J Hypertens2004，17，7： | 1 |
| 7 | Sulfometuron persistence and movement in soil and water in North Dakota显示文摘 | Lyn R G Sweuson O R | 1991 | J Environ Qual1991，20，： | 1 |
| 8 | Continuous metabolic syndrome risk score,body mass index percentile,and leisure time physical activity in American children显示文摘 | Okosun IS Boltri JM Lyn R | | 0，，： | 1 |
| 9 | Building on models of information be- haviour: linking information seeking and communication 显示文摘 | ANDREW R LYN R | 2013 | Journal of Documentation2013，69，2： | 1 |
| 10 | The 894T allele of endothelial nitric oxide synthase gene is related to left ventricular mass in African Americans with highnormal blood pressure 显示文摘 | Lapu-Bula R Quarshie A Lyn D | 2005 | J Natl Med Assoc2005，97，2： | 1 |
| 11 | The physiological role of nitric oxide显示文摘 | Butler A R Williams D Lyn H | 1993 | Chemical society reviews1993，22，4： | 1 |
| 12 | Preparation of Accurate, Low-Concentration Gas Cylinder Standards by Cryogenic Trapping of a Permeation Tube Gas Stream 显示文摘 | Lyn Gameson Rhoderick G C Guenther F R | 2012 | Anal Chem2012，84，： | 1 |
| 13 | Building on models of infor- mation be-haviour:linking information seeking and communica- tion 显示文摘 | ANDREW R LYN R | 2013 | Journal of Documentation2013，，2： | 1 |
| 14 | Directimaging of the disruption of hepatitis C virus replicationcomplexes by inhibitors of lipid metabolism 显示文摘 | Lyn R K Kennedy D C Sagan S M | 2009 | Virology2009，394，1： | 1 |
| 15 | Continuous metabolic syn- drome risk score, body mass index percentile, and leisure time physical activity in American children 显示文摘 | OKOSUN IS BOLTRI JM LYN R | 2010 | J Clin Hypertens ( Greenwich )2010，12，8： | 1 |
| 16 | A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach显示文摘 | Matthew P Johnson Lyn R Griffiths | 2005 | J Hum Genet2005，50，： | 1 |
| 17 | Activity-basedprotein profiling identifies a host enzyme,carboxylesterase 1,which is differentially active duringhepatitis C virus replication 显示文摘 | Blais D R Lyn R K Joyce M A | 2010 | J Biol Chem2010，285，25： | 1 |
| 18 | Bidirectionallipid droplet velocities are controlled by differentialbinding strengths of HCV core DII protein 显示文摘 | Lyn R K Hope G Sherratt A R | 2013 | PLOSONE2013，8，78： | 1 |
| 19 | Applying reliability models more effectively显示文摘 | Lyn M R Nicola A | 1992 | IEEE Software1992，，7： | 1 |
| 20 | Nutrition and physical ac- tivity in child care centers: the impact of a wellness policy initiative on environment and policy assessment and observa- tion outcomes ,2011 显示文摘 | Lyn R Maalouf J Evers S | 2013 | Prev Chronic Dis2013，10，： | 1 |
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