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| 1 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 2 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 3 | Molecular basis of inherited calcium channelopathies:role of mutations in pore-forming subunits显示文摘形成毛孔的高山哈电压门钙隧道的子单元包含响应房间去极位于钙流入下面的必要生物物理的机械。在有需要的辅助子单元的联合,这些毛孔子单元形成对从精子到神经原的多样的房间的生理学和药理学枢轴的钙隧道建筑群。不令人惊讶地,在毛孔子单元的变化产生多样的病理,称为的 channelopathies,那在联合到夜盲的刺激收缩从失败。在最后十年,进致病的机制的主要卓见从自发的出现的动物或诱发突变被导出。在平行,在我们从结构功能,规定和房间生物学观点的电压门离子隧道的活动方式的理解有可观的生长。这里,我们记录我们位于包含电压门钙隧道高山的 channelopathies 下面的变化的当前的理解哈在人和另外的种类的子单元。 | Lynn MCKEOWN Philip ROBIN Owen T JONES | 2006 | Acta Pharmacologica Sinica2006，27，7： | 2 |
| 4 | Analysis of derivatized bio-genie aldehydes by LC tandem mass spectrometry显示文摘 | WII/2AMS T I LOVELL M A LYNN B C | 2005 | Analytical Chemis- try2005，77，10： | 1 |
| 5 | The diagnosis of congenital adrenal hyperplasia in the newborn by gas chromatography/mass spectrometry analysis of random urine specimens显示文摘 | Caulfield MP Lynn T Gottschalk ME | 2002 | J Clin Endocrinol Metab2002，87，8： | 1 |
| 6 | Nitrogen fertilizer efficiencies on potatoes 显示文摘 | DALE T W GALE E K LYNN K P | 1988 | Potato Research1988，65，7： | 1 |
| 7 | Avian beta-defensin nomenclature: a community proposed update 显示文摘 | LYNN D J HIGGS R LLOYD A T | 2007 | Immunol Lett2007，110，： | 1 |
| 8 | The Influence of the Newspaper Media on the Corporate Governance Practices of Irish Listed PLCS显示文摘 | Gorman L Lynn T G Mulgrew M L | 2009 | Electronic Journal2009，7，3： | 1 |
| 9 | Mitochondrial diabetes:investigation and identification of a novel mutation显示文摘 | Lynn S Wardell T Margaret A | 1998 | Diabetes1998，47，： | 1 |
| 10 | Sex differences in second lan- guage comprehension 显示文摘 | PAYNE T W LYNN | 2011 | Personality and Individual Differences2011，，3： | 1 |
| 11 | Avian beta defensin nomenclature: a community proposed update 显示文摘 | Lynn D J Higgs R Lloyd A T | 2007 | Immunology Letters2007，110，1： | 1 |
| 12 | Creating strategic alliances which endure 显示文摘 | SPEKMEN R E A I LYNN T C MACAVOY I FORBES | 1996 | Long Range Planning1996，29，3： | 1 |
| 13 | Anesthesia and analge-sia during and after surgery in neonates 显示文摘 | Berde CB Jaksic T Lynn AM | 2005 | Clin Ther2005，27，： | 1 |
| 14 | Systemic responses to tourniquet release in children显示文摘 | Lynn AM Fischer T Brandford HG | 1986 | Anesth Analg1986，65，8： | 1 |
| 15 | Regulation of flowering in Arabidopsls by an FLC homologue 显示文摘 | Oliver J Ratcliffe Greg C Nadzan T Lynne Reuber et | 2001 | Plant Physiol2001，126，： | 1 |
| 16 | Angiotensin converting enzyme inhibitor use is associated with higher bone mineral density in elderly Chinese显示文摘 | Lynn H Kwok T Wong SY | 2006 | Bone2006，38，4： | 1 |
| 17 | Skill in Estimation Problems of Extent and Numerosity 显示文摘 | Siegel A W Lynn T G Camilla R M | 1982 | Journal for Research in Mathematics Education1982，，13： | 1 |
| 18 | LZTS2 Is a Novelβ-Catenin Interacting Protein and Regulates the Nuclear Export ofβ-Catenin显示文摘 | Gregory T Tzu-Huey L Lynn L | 2006 | Mol Cell Biol2006，26，23： | 1 |
| 19 | Mitochoudrial diabetes:investigation and identification of a novel mutation显示文摘 | Lynns Wardell T Johnson MA | 1998 | Diabetes1998，47，： | 1 |
| 20 | Longevity of granular iron in groundwater treatment processes:Corrosion product devclopment显示文摘 | Kohn T Livi K J T Lynn Roberts A | 2005 | Environmental Science & Technology2005，39，8： | 1 |
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