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| 1 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 2 | Controlled Polymerization of Methyl Methacrylate and Styrene via Cu(0)-Mediated RDRP by Selecting the Optimal Reaction Conditions显示文摘Cu(0)-mediated reversible deactivation radical polymerization(Cu(0)-mediated RDRP) has been demonstrated as an excellent technique to control the polymerization of multiple vinyl monomers(e.g., acrylates, methacrylates, and styrene). However, the complexity of the reaction mechanism and multi-component system nature make it challenging to choose the appropriate conditions and consider the factors of achieving controllable polymerization when switching from one monomer to others with different reactivities. Herein, by polymerizing two examplary monomers: methyl methacrylate(MMA) and styrene via Cu(0)-mediated RDRP under different conditions,we have found that the reaction parameters(e.g., initiator, ligand, solvent, and deactivator) play a crucial role in regulating two equilibriums:(i) mutual conversion of different copper species which determines the relative concentration of Cu(Ⅰ) and Cu(Ⅱ), and(ii)polymerization equilibrium which is the combination of activation/deactivation, propagation and termination processes. We have demonstrated that by taking both the mutual conversion of different copper species and the polymerization equilibrium into account, the optimal reaction conditions could be selected, and the well-controlled Cu(0)-mediated RDRPs of methyl methacrylate and styrene were achieved with narrow molecular weight distributions and predicted molecular weight. | Yong-Peng Miao Jing Lyu Hai-Yang Yong Sigen A Yong-Sheng Gao Wen-Xin Wang | 2019 | Chinese Journal of Polymer Science2019，37，6： | 2 |
| 3 | Use of the Mirena LNG- IUS and Paragard CuT380A intrauterine devices in nulli- parous women显示文摘 | Lyus R Lohr P Prager S et a/ | 2010 | Contraception2010，81，5： | 1 |
| 4 | Applying reliability models more effectively显示文摘 | Nikora A | 1992 | IEEE Software1992，，7： | 1 |
| 5 | Applying reliability models more effectively显示文摘 | Lyu M R Nikora A | 1992 | IEEE Software1992，9，4： | 1 |
| 6 | Applying Reliability Models More Effectively显示文摘 | Lyu M R Nikora A | 1992 | IEEE Software1992，9，4： | 1 |
| 7 | Optimal allocation of test resources for software reliability growth modeling in software development显示文摘 | Lyu M R Rangarajan S Moorsel A P A | 2002 | IEEE Transactions on Reliability2002，51，2： | 1 |
| 8 | Block copolymer in ho- mopolymer blends: Interface vs micelles显示文摘 | Adedeji A Lyu S Macosko C W | 2001 | Macromole- cules2001，34，25： | 1 |
| 9 | Identification and testing of superior reference genes for a starting pool of transcript ormalization in Arabidopsis显示文摘 | Hong S M Bahn S C Lyu A | | 0，，10： | 1 |
| 10 | Intelligent Simulation Model to Evaluate Scheduling Strategies in a Steel Company显示文摘 | LYU J GUNASEKARAN A | 1997 | International Journal of Systems Science1997，28，6： | 1 |
| 11 | Validation of candidate reference genes for the accurate normalization of real-time quantitative RT-PCR data in rice during seed development 显示文摘 | Li Q F Sun Sumeul S M Lyu A | 2010 | Plant Mol Biol Rep2010，28，1： | 1 |
| 12 | Applying reliability models more effectively显示文摘 | Lyu M R Nikora A | 1992 | IEEE Software1992，9，4： | 1 |
| 13 | Photoinduced Bending Behavior of Cross-linked Azobenzene Liquid-crystalline Polymer Films with a Poly(oxyethylene) Backbone显示文摘 | Lyu J A Wang W R Xu J X | 2014 | Macromol Rapid Commun2014，35，14： | 1 |
| 14 | Optimization method for building envelope design to minimize carbon emissions of building operational energy consumption using orthogonal experimental design (OED) 显示文摘 | Zhu J J Chew D A S Lyu S N | 2013 | Habitat International2013，37，： | 1 |
| 15 | The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and invivo显示文摘 | Lyu M A Rai D Ahn K S | 2010 | Neoplasia2010，12，5： | 1 |
| 16 | Optimal allo- cation of test resources for software reliability growth modeling in software development显示文摘 | Lyu M R Rangarajan S Van Moorsel A P A | 2002 | IEEE Transactions on reliability2002，51，2： | 1 |
| 17 | Optimal allocation of test resources for software reliability growth modeling in software development显示文摘 | Lyu M R Rangarajan S Van M A P A | 2002 | IEEE Transactions on Reliability2002，51，2： | 1 |
| 18 | Immunogenicity of a fusion protein linking the beta subunit carboxyl terminal peptide of human chorionic gonadotropin to the B subunit of Escherichia coli heat-labile enterotoxin显示文摘 | Rock E P Reich K A Lyu D M | 1996 | Vaccine1996，14，16： | 1 |
| 19 | Applying reliability models more effec- tively 显示文摘 | Lyu M R Nikora A | 1992 | IEEE Software1992，9，4： | 1 |
| 20 | Seungma-galgeun-tang attenuates proinflammatory activities through the inhibition of NF-kappaB signal pathway in the BV-2 microglial cells 显示文摘 | Lyu S A Lee S Y Lee S J Son S W Kim M O Kim G Y | 2006 | J Ethnopharmacol2006，107，： | 1 |
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