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| 1 | B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors显示文摘The most common digestive system(DS)cancers,including tumors of the gastrointestinal tract(GIT)such as colorectal cancer(CRC),gastric cancer(GC)and esophageal cancer(EC)as well as tumors of DS accessory organs such as pancreatic and liver cancer,are responsible for more than one-third of all cancerrelated deaths worldwide,despite the progress that has been achieved in anticancer therapy.Due to these limitations in treatment strategies,oncological research has taken outstanding steps towards a better understanding of cancer cell biological complexity and heterogeneity.These studies led to new molecular target-driven therapeutic approaches.Different in vivo and in vitro studies have revealed significant expression of B7 homologue 3(B7-H3)among the most common cancers of the GIT,including CRC,GC,and EC,whereas B7-H3 expression in normal healthy tissue of these organs was shown to be absent or minimal.This molecule is able to influence the biological behavior of GIT tumors through the various immunological and nonimmunological molecular mechanisms,and some of them are shown to be the result of B7-H3-related induction of signal transduction pathways,such as Janus kinase 2/signal transducer and activator of transcription 3,phosphatidylinositol 3-kinase/protein kinase B,extracellular signal-regulated kinase,and nuclear factor-κB.B7-H3 exerts an important role in progression,metastasis and resistance to anticancer therapy in these tumors.In addition,the results of many studies suggest that B7-H3 stimulates immune evasion in GIT tumors by suppressing antitumor immune response.Accordingly,it was observed that experimental depletion or inhibition of B7-H3 in gastrointestinal cancers improved antitumor immune response,impaired tumor progression,invasion,angiogenesis,and metastasis and decreased resistance to anticancer therapy.Finally,the high expression of B7-H3 in most common cancers of the GIT was shown to be associated with poor prognosis.In this review,we summarize the established data from different GIT cancer-related studies and suggest that the B7-H3 molecule could be a promising prognostic biomarker and therapeutic target for anticancer immunotherapy in these tumors. | Petar Rasic Maja Jovanovic-Tucovic Marija Jeremic Slavisa M Djuricic Zorica V Vasiljevic Maja Milickovic Djordje Savic | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 2 |
| 2 | Particle filtering显示文摘 | PETAR M Djuric JAUESH H Kotecha Jianqui Zhang etal | 2003 | IEEE Signal Processing Magazine2003，20，5： | 1 |
| 3 | Radical abdominal trachelectomy in the 19th gestation week in patients with early invasive cervical carcinoma: case study and overview of literalure显示文摘 | Aljosa M Petar N Dejan N | 2009 | Am J Obstet Gynecol2009，201，： | 1 |
| 4 | Altered genes expression pattern in dendritic cells after severe trauma 显示文摘 | Marcus M Sebastian W Petar T | 2006 | Shock2006，26，41： | 1 |
| 5 | Altered gens expression pattern in dendritic cells after severe trauma 显示文摘 | Marcus M Sebastian W Petar T | 2006 | Shock2006，26，41： | 1 |
| 6 | Performance comparison of Gaussian-based filters using information measures显示文摘 | MAHESH V MONICA F B Petar M D | 2007 | IEEE Signal Processing Letters2007，14，12： | 1 |
| 7 | Another look at the molecular mechanism of the resistance of H5N1 influenza A virus neuraminidase (NA) to oseltamivir (OTV)显示文摘 | MARIJA L MIHAJLOVI C PETAR M | 2008 | Biophysical Chemistry2008，136，： | 1 |
| 8 | Particle filtering 显示文摘 | Petar M Djuric Jayesh H Kutecha Jianqui Zhang | 2003 | IEEE Signal Processing Mag- azine2003，20，5： | 1 |
| 9 | The thermogravi-metric analysis of some polysiloxanes 显示文摘 | JOVANOVIC J D GOVEDARICA M N PETAR R D | 1998 | Polym Degrad Stab1998，61，： | 1 |
| 10 | Gaussian sum particle filtering 显示文摘 | JAYESH H K PETAR M D | 2003 | IEEE Transactions on Signal Processing2003，51，10： | 1 |
| 11 | Particle filtering显示文摘 | M Petar | 2003 | IEEE Signal ProcessingMaga-zine2003，20，5： | 1 |
| 12 | Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity显示文摘 | Jennifer L Dotson Jeffrey S Hyams James Markowitz Neal S LeLeiko David R Mack Jonathan S Evans Marian D Pfefferkorn Anne M Griffiths Anthony R Otley Athos Bousvaros Subra Kugathasan Joel R Rosh David Keljo Ryan S Carvalho Gitit Tomer Petar Mamula Marsha H | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 13 | Gaussian particle filtering显示文摘 | Jayesh H Kotecha Petar M | 2003 | IEEE Transactions on signal processing2003，51，10： | 1 |
| 14 | Target tracking by particle filtering in binary sensor networks 显示文摘 | Petar M D Mahesh V Mdnica F B | 2008 | IEEE Transactions on Signal Processing2008，56，6： | 1 |
| 15 | Sequential monte carlo sampling detector for rayleigh fast-fading channels 显示文摘 | Jayesh H Kotecha and Petar M Djuric | 2000 | International Conference on Acoustics Speech and Signal Processing2000，1，59： | 1 |
| 16 | Gaussian Particle Filtering 显示文摘 | H Jayesh Kotecha Petar M Djuric | 2003 | IEEE Transactions on Signal Processing (S1053-587X)2003，51，10： | 1 |
| 17 | Particle filtering显示文摘 | Petar M Djuric | 2003 | IEEE SignalProcessing Magazine2003，20，5： | 1 |
| 18 | Particle Filtering显示文摘 | Jayesb H Zhang Jianqiu | 2003 | IEEE Signal Processing Magazine2003，20，5： | 1 |
| 19 | Particle filtering显示文摘 | PETAR M DJURIC JAYESH H Kotecha HANQUI ZHANG | 2003 | IEEE Signal Processing Magazine2003，20，5： | 1 |
| 20 | Gaussian particle filtering显示文摘 | Kotecha Jayesh H Djuric Petar M | 2003 | IEEE Trans on signal processing2003，51，10： | 1 |
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