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| 1 | 水稻叶片叶绿素和过氧化氢含量的QTL检测及上位性分析(英文)显示文摘研究水稻叶片叶绿素和过氧化氢含量的遗传规律 ,对探讨光合代谢产物遗传规律和开展高产育种具有重要指导意义。利用由日本晴 Kasalath∥日本晴的杂交组合衍生的 98个回交重组自交家系 (BC1 F9)所组成的BIL(backcrossinbredlines)群体 ,在第 1、2、3和 10染色体上分别检测出 5个与叶绿素含量相关的QTL和 2个影响剑叶过氧化氢含量的QTL ,其中位于第 1染色体的RFLP标记C86和C813之间的q Chl1对叶绿素含量的影响最为显著 ,对表型变异的贡献率达 2 2 %,其增效基因来自粳稻品种日本晴 ;同时在该区间检测到 1个与剑叶过氧化氢含量相关的QTL :q H2 O2 1,对过氧化氢含量的减效基因来自日本晴品种。上位性分析结果显示影响叶绿素含量及过氧化氢含量的非等位QTL之间存在显著的上位性效应。具有上位性效应的QTL分布于第 2、6、11和 12染色体上 ,未检测到与q Chl1或q H2 O2 1互作的位点。暗示日本晴品种的RFLP标记C86和C813之间存在 1个能够提高叶绿素含量 ,同时又能降低过氧化氢含量的主效QTL ,其加性效应显著而不存在上位性效应。 | 杨权海 陆巍 胡茂龙 王春明 张荣铣 M Yano 万建民 | 2003 | Acta Genetica Sinica2003，30，3： | 23 |
| 2 | 小胶质细胞可能通过选择性吞噬丘脑底核谷氨酸能突触来代偿多巴胺能神经元丢失造成的帕金森模型鼠的功能缺失显示文摘当帕金森患者出现临床症状时,其黑质致密部的绝大部分多巴胺神经元已发生退行性改变。这提示可能存在某些代偿机制,延缓了临床症状的出现。本研究制作6-羟多巴胺诱导的偏侧帕金森大鼠模型,观察位于黑质下网状部和苍白球的激活的小胶质细胞在代偿机制中的作用。研究发现,在偏侧帕金森大鼠中,黑质下网状部聚集的激活的小胶质细胞远多于苍白球中。激活的小胶质细胞胞体增大并表达吞噬物标志物CD68和NG2蛋白多糖。激活的小胶质细胞聚集在黑质下网状部的特定部位,该部位的突触蛋白I和突触后密集蛋白95的表达降低。活化的小胶质细胞吞噬突触前、后膜上的各种蛋白,包括NMDA受体。将红色荧光标记物Di I作为顺行示踪剂注入丘脑底核,可见黑质下网状部和苍白球内的细胞吞噬了Di I。在谷氨酸刺激下,原代培养的小胶质细胞吞噬活动增强,编码吞噬相关因子的m RNA转录水平也增加。人工合成的糖皮质激素地塞米松可以减弱这种改变。给PD大鼠皮下注射地塞米松,可以抑制黑质下网状部小胶质细胞的活化,运动功能障碍进一步加重,谷氨酸能突触转录m RNA增加,GABA能突触转录m RNA水平未增加。这些发现提示,当谷氨酸能神经元活动增强时,黑质下网状部和苍白球的小胶质细胞活化,选择性吞噬丘脑底核的谷氨酸能突触。因此,在基底核区可能存在一个负反馈环路,间接地代偿了由于多巴胺能神经元丢失而导致的功能障碍。小胶质细胞在这个负反馈环路中扮演了重要的角色。 | Aono H Choudhury ME Higaki H Miyanishi K Kigami Y Fujita K Akiyama JI Takahashi H Yano H Kubo M Nishikawa N Nomoto M Tanaka J 唐颖馨 | 2017 | 神经损伤与功能重建2017，12，5： | 7 |
| 3 | Diagnosis of early gastric cancers by an endoscopic autofluoredcence imaging system显示文摘 | Yano H Lishi H Tstsura M | 1996 | Endoscopy1996，28，： | 4 |
| 4 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 5 | The long-term pathological evolution of chronic hepatitis C显示文摘 | M Yano H Kumada M Kage K Ikeda K Shimamatsu O Inoue E Hashimoto JH Lefkowitch J Ludwig K Okuda | 1996 | Hepatology1996，，6： | 2 |
| 6 | Insulin resistance and classic risk factors in type 2 diabetic patients with different subtypes of ischemic stroke显示文摘 | Matsumoto K Miyake S Yano M | 1999 | Diabetes Care1999，22，： | 1 |
| 7 | Frontal skull base surgery combined with endonasal endoscopic sinus surgery显示文摘 | Morioka M Hamada J Yano S | 2005 | Surg Neurol2005，64，1： | 1 |
| 8 | Quantitative analysis of ceramide molecular species by high perform ante liquid chromatography显示文摘 | Yano M Kishida E Muneyuki Y | 1998 | J Lipid Res1998，39，： | 1 |
| 9 | Hd1, a major photoperiod sensitivity quantitative trait locus in rice, is closely related to the Arabidopsis flowering time gene CONSTANS 显示文摘 | Yano M Katayose Y Ashikari M | | Plant Cell0，，12： | 1 |
| 10 | Prognosis in patients with hepatocellular carcinoma correlates to mutations of p53 and/or hMSH2 genes 显示文摘 | YANO M HAMATANI K EGUCHI H | 2007 | Eur J Cancer2007，43，6： | 1 |
| 11 | Occurrence of Vibrio vulnificus in fish and shellfish available from markets in China 显示文摘 | YANO Y YOKOYAMA M SATOMI M | 2004 | J Food Prot2004，67，8： | 1 |
| 12 | Gene transfer of heat shock protein 70 protects lung grafts from ischemia-reperfusion injury显示文摘 | Mara B Yano M | 1999 | Ann Thorac Surg1999，67，： | 1 |
| 13 | Short-term of high glucose concen-tration induces generation of reactive species in endothelial cells:impli-cation for the oxidative stress associated with postprandial hypcrglycemi-a显示文摘 | Hasegawa G Ishii M et ol | 2004 | Redox Rep2004，9，2： | 1 |
| 14 | Multi institutional randomized phase I trial of gefitinib for previously treated patients with advanced non-smallcell lung cancer显示文摘 | Fukuoka M Yano S Giaccone G | 2003 | J Clin Oncol2003，21，12： | 1 |
| 15 | Spleen- preserving distal pancreatectomy with conservation of the splenic artery and vein: techniques and its signifieanee显示文摘 | KIMURA W YANO M SUGAWARA S | 2010 | J Hepatobiliary Pancreat Sei2010，17，6： | 1 |
| 16 | Rice gibberellin-insensitive dwarf mutant gene Dwarf 1 encodes the a-subunit of GTP-binding protein显示文摘 | Ashikari M Wu J Z Yano M | 1999 | Proceeding of the National Academy of Sciences of the USA1999，96，10： | 1 |
| 17 | Biomechanical effect of abutment on stability of orthodontic mini-implant: A finite element analysis 显示文摘 | Motoyoshi M Yano S Tsuruoka T | 2005 | Clin Oral Implants Res2005，16，4： | 1 |
| 18 | Active hepatic capsulitis caused by Pargonimus westermani infection 显示文摘 | Sasald M Kamiyama T Yano T | 2002 | Intern Med2002，41，： | 1 |
| 19 | Distorted segregation of RFLP markers in regenerated plants derived from anther culture of a F1 hybrid of rice显示文摘 | Yamagishi M Yano Y Fukuta K | 1996 | Genes Genet Syst1996，71，： | 1 |
| 20 | Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia 显示文摘 | Abid M R Yano K Guo S | 2005 | J Biol Chem2005，280，29： | 1 |
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