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| 1 | Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization显示文摘AIM: To determine the role of interleukin (IL)-17 in gastric ulcerogenesis. METHODS: Thirty-six gastric ulcer (GU) patients and 29 non-ulcer (NU) patients were enrolled in this study. Mucosal biopsy samples were obtained from the gastric antrum and GU site during endoscopy. Samples were used in in situ stimulation for 48 h in the presence of 10 μg/mL phytohemagglutinin-P (PHA), histological examination, and Helicobacter pylori(H pylori) culture. IL-17 and IL-8 protein levels in culture supernatants were assayed by ELISA. IL-17 mRNA expression was analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). H pylori cagA and vacA status was assessed by reverse hybridization using a line probe assay (LiPA). IL-8 levels in culture supernatants were assayed after AGS cells were co-cultured with H pylori strain 26 695 or recombinant human (rh) IL-17. RESULTS: All 36 GU patients and 15 of 29 NU patients were found to be H pylori-positive, while 14 NU patients were H pylori-negative. All 51 H pylori strains from both GU and NU patients were cagA- and vacAs1/m1-positive. Antral mucosal tissues from H pylori-positive patients contained significantly (H pylori-positive NU patients: median 467 pg/mg/protein, range 53-2 499; H pylori-negative NU patients: median 104 pg/mg/protein, range 16-312, P<0.0005) higher levels of IL-17 than those from uninfected patients. IL-17 levels at the ulcer site were significantly (ulcer site: median 1356 pg/mg/protein, range 121-1 3730; antrum: median 761 pg/mg/protein, range 24-7 620, P<0.005) higher than those at distant sites in the antrum. Biopsies from H pylori-positive GU and NU patients showed IL-17 mRNA expression in all samples whereas those from the antrum of the H pylori-negative controls showed no detectable expression. A significant correlation was seen between IL-17 and IL-8 levels at each biopsy site (ulcer: r= 0.62, P<0.0001; antrum: r = 0.61, P<0.0001) in GU patients. RhIL-17 and H pylori strain 26 695 each stimulated IL-8 production from AGS cells. CONCLUSION: IL-17 may play an important role in the inflammatory response to H pylori colonization, and may ultimately influence the outcome of H pylori-associated diseases that arise within the context of gastritis. | Tomokazu Mizuno Takafumi Ando Kazuo Nobata Tomoyuki Tsuzuki Osamu Maeda Osamu Watanabe Masaaki Minami Kenji Ina Kazuo Kusugami Richard M. Peek Hidemi Goto | 2005 | World Journal of Gastroenterology2005，11，40： | 18 |
| 2 | Comparison of the polymerase region of small round structured virus strains previously classified in three antigenic types by solid-phase immune electron microscopy显示文摘 | T. Ando M. N. Mulders D. C. Lewis M. K. Estes S. S. Monroe R. I. Glass | 1994 | Archives of Virology (-)1994，，1： | 1 |
| 3 | Preparation of a visible-light-active TiO2 photocatalyst by RF plasma treatment显示文摘 | T. Ihara M. Miyoshi M. Ando S. Sugihara Y. Iriyama | 2001 | Journal of Materials Science2001，，17： | 1 |
| 4 | The effect of hyaluronan on interleukin-1α-induced prostaglandin E2 production in human osteoarthritic synovial cells显示文摘 | T. Yasui M. Akatsuka K. Tobetto M. Hayaishi T. Ando | 1992 | Agents and Actions (-)1992，，1： | 1 |
| 5 | Optical and structural properties of PbI 2 thin films显示文摘 | J. F. Condeles R. A. Ando M. Mulato | 2008 | Journal of Materials Science2008，，2： | 1 |
| 6 | Thyroid hormone action at the cellular, genomic and target gene levels显示文摘 | Paul M. Yen Shinichiro Ando Xu Feng Ying Liu Padma Maruvada Xianmin Xia | 2006 | Molecular and Cellular Endocrinology2006，，1： | 1 |
| 7 | Radiation and helium effects on microstructures, nano-indentation properties and deformation behavior in ferrous alloys显示文摘 | Y. Katoh M. Ando A. Kohyama | 2003 | Journal of Nuclear Materials2003，，2： | 1 |
| 8 | Sputtered silver-based low-emissivity coatings with high moisture durability显示文摘 | E. Ando S. Suzuki N. Aomine M. Miyazaki M. Tada | 2000 | Vacuum2000，，2： | 1 |
| 9 | Thyroid hormone action at the cellular, genomic and target gene levels显示文摘 | Paul M. Yen Shinichiro Ando Xu Feng Ying Liu Padma Maruvada Xianmin Xia | 2006 | Molecular and Cellular Endocrinology2006，，： | 1 |
| 10 | Mapping of quantitative trait loci controlling low-temperature germinability in rice ( Oryza sativa L.)显示文摘 | K. Fujino H. Sekiguchi T. Sato H. Kiuchi Y. Nonoue Y. Takeuchi T. Ando S. Y. Lin M. Yano | 2004 | Theoretical and Applied Genetics2004，，5： | 1 |
| 11 | Indoor and outdoor air pollution in Tokyo and Beijing supercities显示文摘 | M. Ando K. Katagiri K. Tamura S. Yamamoto M. Matsumoto | 1996 | Atmospheric Environment1996，，5： | 1 |
| 12 | Mapping of quantitative trait loci controlling low-temperature germinability in rice (Oryza sativa L.)显示文摘 | K. Fujino H. Sekiguchi T. Sato H. Kiuchi Y. Nonoue Y. Takeuchi T. Ando S. Y. Lin M. Yano | 2004 | Theoretical and Applied Genetics2004，，5： | 1 |
| 13 | Pore structure of porous ceramics synthesized from water-based slurry by freeze-dry process显示文摘 | T. Fukasawa Z.-Y. Deng M. Ando T. Ohji Y. Goto | 2001 | Journal of Materials Science2001，，10： | 1 |
| 14 | Magnetic resonance imaging of the brain in congenital rubella virus and cytomegalovirus infections显示文摘 | K. Sugita M. Ando M. Makino J. Takanashi N. Fujimoto H. Niimi | 1991 | Neuroradiology1991，，3： | 1 |
| 15 | Effect of peppermint feeding on the digestibility, ruminal fermentation and protozoa显示文摘 | Sada Ando T. Nishida M. Ishida K. Hosoda E. Bayaru | 2003 | Livestock Production Science2003，，2： | 1 |
| 16 | A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant显示文摘 | J. Ohnishi S. Mitsuhashi M. Hayashi S. Ando H. Yokoi K. Ochiai M. Ikeda | 2002 | Applied Microbiology and Biotechnology2002，，2： | 1 |
| 17 | Preparation of a visible-light-active TiO2 photocatalyst by RF plasma treatment显示文摘 | T. Ihara M. Miyoshi M. Ando S. Sugihara Y. Iriyama | 2001 | Journal of Materials Science2001，，17： | 1 |
| 18 | 来源异位胰腺的胃腺癌 | Matsuki M. Gouda Y. Ando T. S.Kuriyama 李宏宇 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，11： | 0 |
| 19 | Biotransformation of alpha-santonin by cell suspension cultures of five plants显示文摘 | Yang, L. Dai, J. G. Sakai, J. Ando, M. | 2007 | 中国生物学文摘2007，21，2： | 0 |
| 20 | 肠易激综合征疼痛或不适的意义 | Handa M. Nukina H. Ando K. Kubo C. 陈云茹 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，1： | 0 |
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