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您的检索式：作者名="M.Nicholson"
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| 1 | RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma显示文摘 | GeetaLal LakshmiPadmanabha Brian J.Smith Rachael M.Nicholson James R.Howe M. SueO’Dorisio Frederick E.Domann | 2006 | Cancer2006，，12： | 1 |
| 2 | Using occupancy models to determine mammalian responses to landscape changes显示文摘Determining impacts of anthropogenic landscape changes on wildlife populations is difficult.Besides the challengesDetermining impacts of anthropogenic landscape changes on wildlife populations is difficult.Besides the challenges of designing field studies to document conditions before and after landscape changes occur,assessment of popula-of designing field studies to document conditions before and after landscape changes occur,assessment of popula-tion responses(e.g.changes in population density)often provide poor inference because of sampling limitations.tion responses(e.g.changes in population density)often provide poor inference because of sampling limitations.Estimation of occupancy,however,only requires data on detection or non-detection of a species and might provideEstimation of occupancy,however,only requires data on detection or non-detection of a species and might provide better inference.To demonstrate the utility of occupancy models,we used data from an American black bear(Ursusbetter inference.To demonstrate the utility of occupancy models,we used data from an American black bear(Ursus americanus Pallas)population in North Carolina,USA to test our research hypothesis that documented declines inamericanus Pallas)population in North Carolina,USA to test our research hypothesis that documented declines in site occupancy of black bears would be greater near a new four-lane highway.We used multi-season occupancysite occupancy of black bears would be greater near a new four-lane highway.We used multi-season occupancy models to estimate site occupancy based on bear visitation to survey sites before and after completion of the newmodels to estimate site occupancy based on bear visitation to survey sites before and after completion of the new highway and as a function of distance to the highway.Site occupancy declined from 0.81 to 0.35 between the twohighway and as a function of distance to the highway.Site occupancy declined from 0.81 to 0.35 between the two study phases,but was not a function of distance to the highway.Therefore,the impact of the new highway onstudy phases,but was not a function of distance to the highway.Therefore,the impact of the new highway on occupancy extended to the entire study area.Our case study demonstrates that occupancy models can provideoccupancy extended to the entire study area.Our case study demonstrates that occupancy models can provide powerful inference regarding the potential impacts of landscape changes on species occupancy.As urban areas andpowerful inference regarding the potential impacts of landscape changes on species occupancy.As urban areas and transportation infrastructure are rapidly expanding in developing regions of the world,the need to determine howtransportation infrastructure are rapidly expanding in developing regions of the world,the need to determine how these changes affect mammal populations and how they might be mitigated increases accordingly.Because fieldthese changes affect mammal populations and how they might be mitigated increases accordingly.Because field sampling for occupancy models only requires detection data,surveys can be conducted for extensive geographicsampling for occupancy models only requires detection data,surveys can be conducted for extensive geographic areas,thus making these surveys particularly applicable to studies of large mammals.areas,thus making these surveys particularly applicable to studies of large mammals. | Jeremy M.NICHOLSON Frank T.VAN MANEN | 2009 | Integrative Zoology2009，4，2： | 0 |
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