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您的检索式：作者名="M.S. Murphy"
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| 1 | 输液方式行部分肠道营养治疗儿童活动性克罗恩病:一项随机对照试验显示文摘Background and aims: Total enteral nutrition (TEN) with a liquid formula can suppress gut inflammation and induce remission in active Crohn’s disease. The mechanism is obscure. Studies have suggested that long term nutritional supplementation with a liquid formula (partial enteral nutrition (PEN)) may also suppress inflammation and prevent relapse. The aim of this study was to compare PEN with conventional TEN in active Crohn’s disease. Patients and methods: Fifty children with a paediatric Crohn’s disease activity index (PCDAI) > 20 were randomly assigned to receive 50% (PEN) or 100% (TEN) of their energy requirement as elemental formula for six weeks. The PEN group was encouraged to eat an unrestricted dietwhile those receiving TEN were not allowed to eat. The primary outcome was achievement of remission (PCDAI < 10). Secondary analyses of changes in erythrocyte sedimentation rate (ESR), C reactive protein, albumin, and platelets were performed to look for evidence of anti-inflammatory effects. Results: Remission rate with PEN was lower than with TEN (15% v 42% ; p = 0.035). Although PCDAI fell in both groups (p = 0.001 for both), the reduction was greater with TEN (p = 0.005). Moreover, the fall in PCDAI with PEN was due to symptomatic and nutritional benefits. With both treatments there were significant improvements in relation to abdominal pain, “ sense of wellbeing', and nutritional status. However, only TEN led to a reduction in diarrhoea (p = 0.02), an increase in haemoglobin and albumin, and a fall in platelets and ESR. Conclusions: TEN suppresses inflammation in activeCrohn’s disease but PEN does not. This suggests that long term nutritional supplementation, although beneficial to some patients, is unlikely to suppress inflammation and so prevent disease relapse. | Johnson T. Macdonald S. Hill S.M. M.S. Murphy 程妍 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 3 |
| 2 | Clinical management of blunt trauma patients with unilateral rib fractures: A randomized trial显示文摘 | Sheryl G. A. Gabram M.D. Robert J. Schwartz M.D. M.P.H. Lenworth M. Jacobs M.D. M.P.H. Denise Lawrence R.N. M.S. Marlene A. Murphy M.D. Jeffrey S. Morrow M.D. Julia S. Hopkins R.R.T. R. Frederic Knauft M.D | 1995 | World Journal of Surgery1995，，3： | 1 |
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