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| 1 | Trends of Overweight and Obesity in Yi People between 1996 and 2007:An Yi Migrant Study显示文摘Objective To evaluate trends of overweight and obesity prevalence between 1996 and 2007 in Yi farmers and Yi migrants.Methods An Yi migrant study was conducted in Liangshan Yi Autonomous Prefecture,Sichuan Province,China from 1996 to 2007.Data were collected with identical methods,including standardized questionnaire and body measurements.Results Age‐ and sex‐specific body mass index (BMI) significantly increased from 20.02 in 1996 to 22.36 in 2007,among Yi farmers,which was significantly different from those among Yi migrants (23.67 in 2007 and 20.90 in 1996) (P<0.05).Prevalence of obesity rose from 1.21 % in 1996 to 4.55 % in 2007 (OR=1.15,P<0.001) in Yi migrants,while that in Yi farmers from none in 1996 to 0.12 % in 2007 (P>0.05).Prevalence of overweight rose significantly to 26.24 %in 2007 from 17.24 % in 1996 (OR=1.06,P<0.001) in Yi migrants,while that in Yi farmers from 1.29 % in 1996 to 4.45 % in 2007 (OR=1.14,P<0.001).Yi migrants appeared to have a 5.52‐fold higher risk ondeveloping overweight and obesity than Yi farmers have.Conclusion The Yi migrants had a steeper increase of overweight with year and consequently caused more obesity.Change in lifestyle may contribute most likely to higher prevalence of overweight and obesity in Yi migrants. | SHAN GuangLiang WEI DaYing WANG ChunXiu ZHANG JianHua Wang Bin MA MingJu PAN Li YU Tao XUE Fang WU ZhengLai | 2011 | Biomedical and Environmental Sciences2011，24，5： | 9 |
| 2 | The analysis of a drug transmission model with family education and public health education显示文摘In this paper,we formulate a six dimensional drug transmission model to study the effect of family education and public health education.The dynamical behaviors of the model are discussed in terms of the basic reproduction number R0.By constructing Lyapunov functions,we obtain the drug-free equilibrium is globally asymptotically stable if R0≤1 and the drug addiction equilibrium is globally asymptotically stable if R0>1.Sensitivity analyses are performed to seek for effective control measures for drug spread.The analysis show that both the family and public health education can influence the spread of drug transmission.However,the combination of family and public health education is more effective to reduce the prevalence of drugs.Some numerical simulations are given to confirm the obtained theoretical results. | Jun Li Mingju Ma | 2018 | Infectious Disease Modelling2018，3，1： | 1 |
| 3 | EFFECT OF ACUPUNCTURE ON ELECTROMYOGRAPH OF MYOSITIS AND PATHOLOGY OF MUSCLE显示文摘An animal model of experimental polymyositis(EPM)similar to humampolymyositis(PM)was made by immuning with skeletal muscular homogenate of rabbits.We treatedthem by acupuncturing Zusanli(ST 36)and Xuehai(SP 10)for 8 consecutive weeks and comparedthem with control group.The changes of electromyogram and muscular pathology were analysed.The results show that all changes in acupuncture group are milder than that in control group and sug-gest that acupuncture has some beneficial adjustment for the immunity of PM. | Ma Xiaoping Chen Gongsun Dept.of Acupuncture and Moxibustion,Jiangsu Province People’s Hospital,Nanjing 210029,ChinaChai Sao Sheng Mingju Cheng Weixian Gao Chaoya Nerve Dept.of Jiangsu Province People’s Hospital,Nanjing,ChinaZhou Qi Nanjing Ocorpation Diseases Preavention and Treatment Center,Nanjing,China | 1993 | World Journal of Acupuncture-Moxibustion1993，3，2： | 0 |
| 4 | Bioinformatics exploration of potential common therapeutic targets for systemic and pulmonary arterial hypertension-induced myocardial hypertrophy显示文摘Systemic and pulmonary arterial hypertension(PAH)can induce left and right ventricular hypertrophy,respectively,but common therapeutic targets for both left and right hypertrophy are limited.In this study,we attempt to explore potential common therapeutic targets and screen out potential target drugs for further study.Cardiac mRNA expression profiles in mice with transverse aortic constriction(TAC)and pulmonary arterial constriction(PAC)are obtained from online databases.After bioinformatics analyses,we generate TAC and PAC mouse models to validate the phenotypes of cardiac remodelling as well as the identified hub genes.Bioinformatics analyses show that there are 214 independent differentially expressed genes(DEGs)in GSE136308(TAC related)and 2607 independent DEGs in GSE30922(PAC related),while 547 shared DEGs are associated with the function of the extracellular matrix(ECM)or involved in the PI3K-Akt signaling pathway,cytokine-cytokine receptor interactions,and ECM-receptor interactions.We identifyd Fn1,Il6,Col1a1,Igf1,Col1a2,Timp1,Col3a1,Cd44,Ctgf and Postn as hub genes of the shared DEGs,and most of them are associated with myocardial fibrosis.Those hub genes and phenotypes of cardiac remodelling are validated in our TAC and PAC mouse models.Furthermore,we identify dehydroisoandrosterone(DHEA),iloprost and 4,5-dianilinophthalimide(DAPH)as potential therapeutic drugs targeting both left and right ventricular hypertrophy and validate the effect of DHEA.These findings suggest that DHEA could be an effective drug for pressure overload-induced left or right ventricular hypertrophy by regulating the shared hub differentially expressed genes associated with fibrosis. | Lu Chen Mingjue Li Mengjia Shen Yingqi Zhu Kaitong Chen Xiaoxia Huang Cankun Zheng Qiancheng Wang Hairuo Lin Wangjun Liao Jianping Bin Siyuan Ma Yulin Liao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，5： | 0 |
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