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| 1 | Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: A review显示文摘Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases(IBD) including ulcerative colitis and Crohn's disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls. In the present article, we review the mechanisms in which hyperhomocysteinemia may contribute to increased risk of colorectal cancer in IBD patients. | Ammar Hassanzadeh Keshteli Vickie E Baracos Karen L Madsen | 2015 | World Journal of Gastroenterology2015，21，4： | 21 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | Air pollution effects on the gut microbiota显示文摘 | Saad Y Salim Gilaad G Kaplan Karen L Madsen | 2014 | Gut Microbes2014，，： | 3 |
| 4 | Evaluation and Optimization of DNA Extraction and Purification Procedures for Soil and Sediment Samples 显示文摘 | D N Miller J E Bryant E L Madsen and W C Ghiorse | 1999 | Applied and environmental Microbiolog1999，65，： | 2 |
| 5 | Degradation of phthalate and di-(2-ethylhexyl) phthalate by indigenous and inoculated microorganisms in sludge-amended soil 显示文摘 | Roslev P Madsen P L Thyme J B | 1998 | Appl Environ Microb1998，64，12： | 2 |
| 6 | A receptor kinase gene of the LysM type is involved in legume perception of rhizobial signals显示文摘 | Madsen E B Madsen L H Radutoiu S | 2003 | Nature2003，425，： | 1 |
| 7 | Dynamic hip screw with trochanteric stabilizing plate in the treatment of unstable proximal femoral fractures: a comparative study with the Gamma nail and compression hip screw显示文摘 | Madsen JE Naess L Aune AK | 1998 | J Orthop Trauma1998，12，4： | 1 |
| 8 | On the definition andmodeling of streamflow drought duration and deficit volume显示文摘 | Tallaksen L M Madsen H Clausen B | 1997 | Hydrological Science Journal1997，42，1： | 1 |
| 9 | The use of probiotics in gastrointestinal disease显示文摘 | Madsen K L | 2001 | Can J Gastroentero12001，15，12： | 1 |
| 10 | Residential exposure to plasticizers and its possible role in the pathogenesis of asthma 显示文摘 | Oie L Hersoug LG Madsen JO | 1997 | Environmental Health Perspectives1997，105，97： | 1 |
| 11 | Global account management:The new frontier in relationship management显示文摘 | Yip G S and Madsen T L | 1996 | International Marketing Review1996，13，3： | 1 |
| 12 | Why is there a resource based view? Toward a theory of competitive het- erogeneity 显示文摘 | Hoopes D G Madsen T L Walker G | 2003 | Strategic Management Journal2003，24，10： | 1 |
| 13 | The potent anti-Staphylococcus aureus activity of a sterile rabbit inflammatory fluid is due to a 14-kD phospholipase A2显示文摘 | WEINRAUCH Y ELSBACH P MADSEN L M | 1996 | Journal of Clinical Investigation1996，，： | 1 |
| 14 | Plant recognition bacterial requires two lysM receptor like protein kinases显示文摘 | RADUTOIU S MADSEN L H MADSEN E B | 2003 | Nature2003，425，： | 1 |
| 15 | Quinolone resistance among Salmonella enteria from cattle,broilers,and swine in Denmark显示文摘 | Wiuff C Madsen M Baggesen D L | 2000 | Microb Drug Resist2000，6，： | 1 |
| 16 | The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function显示文摘 | Hallenborg P Feddersen S Madsen L | 2009 | Expert Opin Ther Targets2009，13，： | 1 |
| 17 | Unbundling competitive heterogeneity: Incentive structures and capability influences on technological innovation 显示文摘 | LEIBLEIN M J MADSEN T L | 2009 | Strategic Management Journal2009，30，7： | 1 |
| 18 | Smoking patterns among adolescents with asthma attending upper secondary schools: a community-based study 显示文摘 | Preeht DH Keiding L Madsen M | 2003 | Pediatrics2003，111，51： | 1 |
| 19 | Evaluation and optimization of DNA extraction and purification procedures for soil and sediment samples 显示文摘 | Miller D N Bryant J E Madsen E L | 1999 | Applied and Environmental Microbiology1999，65，： | 1 |
| 20 | Use of field-based stable isotope probing to identify adapted populations and track carbon flow through a phenol-degrading soil microbial community显示文摘 | DeRito C M Pumphrey G M Madsen E L | | 0，，12： | 1 |
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