维普期刊资源整合服务平台（V6.5）

26篇 您的检索式：作者名="MALETZKY"

选中清除导出查看参考文献查看引证文献引用追踪共2页首页上一页第1页下一页末页 /2 跳转

	题名	作者	年代	出处	被引量
1	Bacteriolytic therapy of experimental pancreatic carcinoma显示文摘AIM:To investigate the effectiveness of Clostridium novyi(C.novyi)-NT spores for the treatment of established subcutaneous pancreatic tumor in the syngeneic,immunocompetent Panc02/C57Bl/6 model. METHODS:C.novyi-NT spores were applied intravenously to animals carrying established pancreatic tumors of three different sizes.Systemic immune responses in peripheral blood and spleen were examined by flow cytometry.Supplementary,cytotoxic activity of lymphocytes against syngeneic tumor targets was analyzed. RESULTS:Application of spores identified,that(1) small tumors(<150 mm 3 )were completely unaffected (n=10);(2)very large tumors(>450 mm3)responded with substantial necrosis followed by shrinkage and significant lethality most likely due to tumor lysis syndrome (n=6);and(3)an optimal treatment window exists for tumors of approximately 250 mm 3 (n=21).In this latter group,all tumor-bearing animals had complete tu-mor regression and remained free of tumor recurrence. In subsequent tumor rechallenge experiments a significant delay in tumor growth compared to the initial tumor cell inoculation was observed(tumor volume at day 28:197.8±87.3 mm 3 vs 500.1±50.9 mm3,P<0.05). These effects were accompanied by systemic activation of immune response mechanisms predominantly mediated by the innate arm of the immune system. CONCLUSION:The observed complete tumor regression is encouraging and shows that immunotherapy with C.novyi-NT is an interesting strategy for the treatment of pancreatic carcinomas of defined sizes.	Claudia Maletzki Michael Gock Ulrike Klier Ernst Klar Michael Linnebacher	2010	World Journal of Gastroenterology2010，16，28：	3
2	Inflammation and immunity in the tumor environment显示文摘	Maletzki C Emmrich J	2010	Dig Dis2010，28，45：	1
3	Frameshift-derived neoantigens constitute immunotherapeutic targets for patients with microsatellite-instable haematological malignancies显示文摘	Claudia Maletzki Fabian Schmidt Wilhelm G. Dirks Michael Schmitt Michael Linnebacher	2013	European Journal of Cancer2013，，11：	1
4	The photo-Fenton method-degradation of nitrogen containing organic compounds 显示文摘	Maletzky Bauer R	1998	Chemosphere1998，37，：	1
5	Inflammation and immunity in the tumor environment 显示文摘	Maletzki C Emmrich J	2010	Dig Dis2010，28，45：	1
6	Immobitisation of iron ions on Nation (R) and its applicability to the Photo-Fenton method显示文摘	Maletzky P Bauer R 1999	1999	Chemosphere1999，38，：	1
7	Inflammation and immunity in the tumor environment显示文摘	Maletzki C EmmrichJ	2010	Dig Dis2010，28，45：	1
8	Ex-vivo clonally expanded B lymphocytes infiltrating colorectal carcinoma are of mature immu- nophenotype and produce functional IgG 显示文摘	Maletzki C Jahnke A Ostwald C	2012	PLoS One2012，7，32：	1
9	Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin显示文摘	C. Maletzki U. Klier W. Obst B. Kreikemeyer M. Linnebacher Y. Yoshikai	2012	Clinical and Developmental Immunology2012，，：	1
10	Immobilization of iron ions on nation and its applicability to the photo - Fenton method显示文摘	Maletzky P Bauer R Lahnsteiner J Pouresmael B	1999	Chemosphere1999，38，：	1
11	S100 proteins as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma显示文摘	Maletzki C Bodammer P Breitrück A	2012	Hepat Mon2012，12，10：	1
12	Generation of highly pure fusions of colorectal carcinoma and antigen-presenting cells显示文摘	Ulrike Klier Claudia Maletzki Ernst Klar Michael Linnebacher	2010	Langenbeck’s Archives of Surgery2010，，4：	1
13	Immobilisation of Iron lons on Nafion (R) and Its Applicability to the Photo-Fenton Method显示文摘	Maletzky P Bauer R	1999	Chemosphere1999，38，：	1
14	The photo-Fenton method-degradation of nitrogen containing organic compounds显示文摘	Maletzky P Bauer R	1998	Chemosphere1998，37，5：	1
15	Immobilization of iron ions on nafion and its applicability to the photo-Fenton method显示文摘	Maletzky P Bauer R Lahnsteiner J Pouresmael B		0，，：	1
16	Risk factors for impaired lung function after pulmonary metastasectomy: a prospective observational study of 117 cases显示文摘	Stefan Welter Danjouma Cheufou Christian Ketscher Kaid Darwiche Frank Maletzki Georgios Stamatis	2012	European Journal of Cardio-Thoracic Surgery2012，，2：	1
17	S100 proteins as diagnos-tic and prognostic markers in colorectal and hepatocellular carcinoma显示文摘	Maletzki C Bodammer P Breitruck A	2012	Hepat Mon2012，12，10：	1
18	The photo-Fenton method-degradation of nitrogen containing organic compounds 显示文摘	MALETZKY BAUER R	1998	Chemo-sphere1998，37，：	1
19	Inflammation and Immunity in theTumor Environment 显示文摘	Maletzki C Emmrich J	2010	Dig Dis2010，28，45：	1
20	Statins have an early antiplatelet effect in patients with acute myocardial infarct显示文摘	Maletzky S Fefer P Shenkman B	2011	Platelets2011，22，2：	1

返回顶部每页显示：

共2页首页上一页第1页下一页末页 /2 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示