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304篇 您的检索式:作者名="MALONEY J"
    题名 作者 年代 出处 被引量
1Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris 2016Asian Journal of Andrology2016,18,6:3
2Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease 显示文摘Sethi S Maloney J Grove L 2006Am J Respir Crit Care Med2006,173,9:1
3Accurate computation of the radiation from simple antennas using the finite- difference time- domain method显示文摘Maloney J G Smith G S Scott W R JR 1990IEEE Trans Antennas and Propagat1990,38,7:1
4Hormones in the mentally disturbed brain:steroids and peptides in the development and treatment of psychopathology显示文摘Taylor GT Maloney S Dearborn J 0,,04:1
5Pre - B - cell colo- ny - enhancing factor as a potential novel biomarker in acute lung in- jury显示文摘YE S Q SIMON B A MALONEY J P 2005Am J Respir Crit Care Med2005,171,4:1
6Stresses and strains in the medial meniscus of an ACL deficient knee under anterior loading:a finite element analysis with image-based experimental validation显示文摘Yao J Snibbe J Maloney M 2006J Biomech Eng2006,128,1:1
7Pre-B-cell colony-enhancing factor as a potential novelbiomarker in acute lung injury 显示文摘YE S Q SIMON B A MALONEY J P 2005Am J RespirCrit Care Med2005,171,4:1
8Proinflammatory cytokines and metalloproteases are expressed in the sub- acromial bursa in patients with rotator cuff disease 显示文摘Voloshin I Gelinas J Maloney MD 2005Ar- throscopy2005,21,9:1
9The use of surface impedance concepts in the finite-difference time domain method显示文摘 Smith G S 1992IEEE Trans AP1992,40,1:1
10Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1 显示文摘Whitby R J Dixon S Maloney P R 2006J Med Chem2006,49,:1
11Thermal network predictions of the daily temperature fluctuations in a direct gain room 显示文摘Maloney J Wang T Chen B 1982Solar Energy1982,29,3:1
12Conductive keratoplasty for the correction of hyperopia显示文摘Asbell PA Maloney RK Davidorf J 2001Trans Am Ophthalmol Soc2001,99,:1
13Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury显示文摘Ye S Q Simon B A Maloney J P 2005Am J Respir Crit Care Med2005,171,4:1
14Effect of a yeast product in pelleted diets for weanling pigs显示文摘MALONEY C A NEMECHEK C S HANCOCK J D 1998Journal of Animal Science1998,76,:1
15Radiofrequency catheter ablation for management of symptomatic ventricular ectopic activity显示文摘Zhu D W Maloney J D Simmons T W 0,,:1
16Influence of coal preoxidation and the relation between char structure and gasification potential显示文摘Maloney D J Jenkins R G 1985Fuel1985,64,:1
17Stresses and strains in the medial meniscus of an ACL deficient knee under anterior loading:a finite element analysis with image-based experimental validation显示文摘Yao J Snibbe J Maloney M 2006J Biomech Eng2006,128,1:1
18The diffusion of water across the stratum corneum as a function of its water content 显示文摘 Maloney J Emslie AG 1984J Invest Dermatol1984,82,:1
19A Simple FDTD Model for Transient Excitation of Antennas by Transmission Line显示文摘MALONEY J G SHLAGER K L SMITH G S 1994IEEE Trans- actions on Antennas and Propagation1994,42,2:1
20Optimization of Bow-Tie antennas for pulse radiation 显示文摘SHLAGER K L SMITH G S MALONEY J G 1994IEEE Transactions on Antennas and Propagation1994,42,7:1
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